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Article: Functionalized europium nanorods for in vitro imaging

TitleFunctionalized europium nanorods for in vitro imaging
Authors
Issue Date2008
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/ic
Citation
Inorganic Chemistry, 2008, v. 47 n. 12, p. 5190-5196 How to Cite?
AbstractEmissive europium hydroxide nanorods (ENR) (20 nm x 500 nm) functionalized by a surface coating of chromophore-containing organically modified silicate (ORMOSIL) layer, have been synthesized and characterized by high-resolution transmission electron microscopy (TEM). Low-temperature photophysical characterization of the functionalized nanorods (FENR) demonstrated a strong red 5D0 luminescence both in solid and in suspended solutions. Potentials of this nanorod material for live cell imaging have also been explored. Both the bare and functionalized nanorods are able to enter living human cells with no discernible cytotoxicity. Chromophore-to-Eu 3+ energy-transfer in the functionalized nanorods enables staining of the cytoplasm of living human cells. This is confirmed by costaining with fluorescent dextran. The red chromophore-sensitized luminescence from the internalized nanorods in live human lung carcinoma cells (A549) can be observed by confocal microscopy 2 h after loading and reaches maximal emission after 24 h. © 2008 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/70031
ISSN
2015 Impact Factor: 4.82
2015 SCImago Journal Rankings: 1.873
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KLen_HK
dc.contributor.authorLaw, GLen_HK
dc.contributor.authorMurphy, MBen_HK
dc.contributor.authorTanner, PAen_HK
dc.contributor.authorWong, WTen_HK
dc.contributor.authorLam, PKSen_HK
dc.contributor.authorLam, MHWen_HK
dc.date.accessioned2010-09-06T06:19:04Z-
dc.date.available2010-09-06T06:19:04Z-
dc.date.issued2008en_HK
dc.identifier.citationInorganic Chemistry, 2008, v. 47 n. 12, p. 5190-5196en_HK
dc.identifier.issn0020-1669en_HK
dc.identifier.urihttp://hdl.handle.net/10722/70031-
dc.description.abstractEmissive europium hydroxide nanorods (ENR) (20 nm x 500 nm) functionalized by a surface coating of chromophore-containing organically modified silicate (ORMOSIL) layer, have been synthesized and characterized by high-resolution transmission electron microscopy (TEM). Low-temperature photophysical characterization of the functionalized nanorods (FENR) demonstrated a strong red 5D0 luminescence both in solid and in suspended solutions. Potentials of this nanorod material for live cell imaging have also been explored. Both the bare and functionalized nanorods are able to enter living human cells with no discernible cytotoxicity. Chromophore-to-Eu 3+ energy-transfer in the functionalized nanorods enables staining of the cytoplasm of living human cells. This is confirmed by costaining with fluorescent dextran. The red chromophore-sensitized luminescence from the internalized nanorods in live human lung carcinoma cells (A549) can be observed by confocal microscopy 2 h after loading and reaches maximal emission after 24 h. © 2008 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/icen_HK
dc.relation.ispartofInorganic Chemistryen_HK
dc.titleFunctionalized europium nanorods for in vitro imagingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0020-1669&volume=47&spage=5190&epage=5196&date=2008&atitle=Functionalized+Europium+Nanorods+for+In+Vitro+Imaging+en_HK
dc.identifier.emailLaw, GL: h049044@hkusua.hku.hken_HK
dc.identifier.emailWong, WT: wtwong@hku.hken_HK
dc.identifier.authorityLaw, GL=rp00723en_HK
dc.identifier.authorityWong, WT=rp00811en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ic8000416en_HK
dc.identifier.pmid18491890-
dc.identifier.scopuseid_2-s2.0-46949090827en_HK
dc.identifier.hkuros146870en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-46949090827&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue12en_HK
dc.identifier.spage5190en_HK
dc.identifier.epage5196en_HK
dc.identifier.isiWOS:000256591400024-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, KL=35239206000en_HK
dc.identifier.scopusauthoridLaw, GL=8640216600en_HK
dc.identifier.scopusauthoridMurphy, MB=7403900446en_HK
dc.identifier.scopusauthoridTanner, PA=7101679850en_HK
dc.identifier.scopusauthoridWong, WT=7403973084en_HK
dc.identifier.scopusauthoridLam, PKS=7202365776en_HK
dc.identifier.scopusauthoridLam, MHW=7202630175en_HK

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