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Article: Ethanol extract of Fructus Ligustri Lucidi promotes osteogenesis of mesenchymal stem cells

TitleEthanol extract of Fructus Ligustri Lucidi promotes osteogenesis of mesenchymal stem cells
Authors
KeywordsBone marrow
Fructus ligustri lucidi
Mesenchymal stem cells
Osteogenesis
Issue Date2010
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567
Citation
Phytotherapy Research, 2010, v. 24 n. 4, p. 571-576 How to Cite?
AbstractFructus Ligustri Lucidi (FLL) has been used in traditional Chinese medicine for over 1000 years. The ethanol extract of FLL (EFLL) has been shown to be a potential candidate in the prevention and treatment of osteoporosis. The present study aimed to determine whether EFLL carries out the effect by promoting osteogenesis in mesenchymal stem cells (MSCs). The osteogenic differentiation of MSCs was evaluated by their alkaline phosphatase (ALP) activities and mineralization. Expression of genes was detected by RT-PCR. We found that EFLL significantly stimulated the ALP activities and shortened the time needed for the mineralization of MSCs during osteogenic differentiation. The expression of several osteoblast differentiation regulators was also upregulated by EFLL during this process. Our study demonstrated that the EFLL is capable of enhancing osteogenic differentiation of MSCs. It might be useful for treating diseases with inadequate bone formation, including osteoporosis. Copyright © 2009 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/69932
ISSN
2014 Impact Factor: 2.660
ISI Accession Number ID
Funding AgencyGrant Number
Li Ka Shing Institute of Health Sciences
RGCCUHK 7422_03M
Funding Information:

The authors would like to thank bone marrow donors. We would also thank Dr David Wilmshurst for editing this paper. This work was supported by the Li Ka Shing Institute of Health Sciences Grant and RGC project: CUHK 7422_03M.

References

 

DC FieldValueLanguage
dc.contributor.authorLi, Gen_HK
dc.contributor.authorZhang, XAen_HK
dc.contributor.authorZhang, JFen_HK
dc.contributor.authorChan, CYen_HK
dc.contributor.authorYew, DTWen_HK
dc.contributor.authorHe, MLen_HK
dc.contributor.authorLin, MCMen_HK
dc.contributor.authorLeung, PCen_HK
dc.contributor.authorKung, HFen_HK
dc.date.accessioned2010-09-06T06:18:10Z-
dc.date.available2010-09-06T06:18:10Z-
dc.date.issued2010en_HK
dc.identifier.citationPhytotherapy Research, 2010, v. 24 n. 4, p. 571-576en_HK
dc.identifier.issn0951-418Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/69932-
dc.description.abstractFructus Ligustri Lucidi (FLL) has been used in traditional Chinese medicine for over 1000 years. The ethanol extract of FLL (EFLL) has been shown to be a potential candidate in the prevention and treatment of osteoporosis. The present study aimed to determine whether EFLL carries out the effect by promoting osteogenesis in mesenchymal stem cells (MSCs). The osteogenic differentiation of MSCs was evaluated by their alkaline phosphatase (ALP) activities and mineralization. Expression of genes was detected by RT-PCR. We found that EFLL significantly stimulated the ALP activities and shortened the time needed for the mineralization of MSCs during osteogenic differentiation. The expression of several osteoblast differentiation regulators was also upregulated by EFLL during this process. Our study demonstrated that the EFLL is capable of enhancing osteogenic differentiation of MSCs. It might be useful for treating diseases with inadequate bone formation, including osteoporosis. Copyright © 2009 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567en_HK
dc.relation.ispartofPhytotherapy Researchen_HK
dc.rightsPhytotherapy Research. Copyright © John Wiley & Sons Ltd.en_HK
dc.rightsThe definitive version is available at www.3.interscience.wiley.com-
dc.subjectBone marrowen_HK
dc.subjectFructus ligustri lucidien_HK
dc.subjectMesenchymal stem cellsen_HK
dc.subjectOsteogenesisen_HK
dc.subject.meshBone Density Conservation Agents - analysis-
dc.subject.meshLigustrum - chemistry-
dc.subject.meshMesenchymal Stem Cells - drug effects - metabolism-
dc.subject.meshOsteogenesis - drug effects-
dc.subject.meshPlant Extracts - pharmacology-
dc.titleEthanol extract of Fructus Ligustri Lucidi promotes osteogenesis of mesenchymal stem cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0951-418X&volume=24&issue=4&spage=571&epage=576&date=2010&atitle=Ethanol+extract+of+Fructus+Ligustri+Lucidi+promotes+osteogenesis+of+mesenchymal+stem+Cellsen_HK
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ptr.2987en_HK
dc.identifier.pmid19813230en_HK
dc.identifier.scopuseid_2-s2.0-77951542282en_HK
dc.identifier.hkuros167697en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951542282&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue4en_HK
dc.identifier.spage571en_HK
dc.identifier.epage576en_HK
dc.identifier.isiWOS:000276802500017-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, G=7407055832en_HK
dc.identifier.scopusauthoridZhang, XA=22996102400en_HK
dc.identifier.scopusauthoridZhang, JF=13007942600en_HK
dc.identifier.scopusauthoridChan, CY=22033276600en_HK
dc.identifier.scopusauthoridYew, DTW=7007034694en_HK
dc.identifier.scopusauthoridHe, ML=35080389700en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK
dc.identifier.scopusauthoridLeung, PC=7401747829en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK

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