Article: Ethanol extract of Fructus Ligustri Lucidi promotes osteogenesis of mesenchymal stem cells
File Download
(May Require Subscription)
- No File Attached
(May Require Subscription)
- Publisher Website: 10.1002/ptr.2987
- Scopus: eid_2-s2.0-77951542282
- PMID: 19813230
- Find via
Supplementary
-
Citations:
-
Appears in Collections:
| Title | Ethanol extract of Fructus Ligustri Lucidi promotes osteogenesis of mesenchymal stem cells | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Li, G2 Zhang, XA2 Zhang, JF2 Chan, CY2 Yew, DTW2 He, ML2 Lin, MCM1 Leung, PC2 Kung, HF2 | ||||||
| Keywords | Bone marrow Fructus ligustri lucidi Mesenchymal stem cells Osteogenesis | ||||||
| Issue Date | 2010 | ||||||
| Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567 | ||||||
| Citation | Phytotherapy Research, 2010, v. 24 n. 4, p. 571-576 [How to Cite?] DOI: http://dx.doi.org/10.1002/ptr.2987 | ||||||
| Abstract | Fructus Ligustri Lucidi (FLL) has been used in traditional Chinese medicine for over 1000 years. The ethanol extract of FLL (EFLL) has been shown to be a potential candidate in the prevention and treatment of osteoporosis. The present study aimed to determine whether EFLL carries out the effect by promoting osteogenesis in mesenchymal stem cells (MSCs). The osteogenic differentiation of MSCs was evaluated by their alkaline phosphatase (ALP) activities and mineralization. Expression of genes was detected by RT-PCR. We found that EFLL significantly stimulated the ALP activities and shortened the time needed for the mineralization of MSCs during osteogenic differentiation. The expression of several osteoblast differentiation regulators was also upregulated by EFLL during this process. Our study demonstrated that the EFLL is capable of enhancing osteogenic differentiation of MSCs. It might be useful for treating diseases with inadequate bone formation, including osteoporosis. Copyright © 2009 John Wiley & Sons, Ltd. | ||||||
| ISSN | 0951-418X 2011 Impact Factor: 2.086 2011 SCImago Journal Rankings: 0.120 | ||||||
| DOI | http://dx.doi.org/10.1002/ptr.2987 | ||||||
| ISI Accession Number ID | WOS:000276802500017
Funding Information: The authors would like to thank bone marrow donors. We would also thank Dr David Wilmshurst for editing this paper. This work was supported by the Li Ka Shing Institute of Health Sciences Grant and RGC project: CUHK 7422_03M. | ||||||
| References | References in Scopus |
| dc.contributor.author | Li, G | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Zhang, XA | ||||||
| dc.contributor.author | Zhang, JF | ||||||
| dc.contributor.author | Chan, CY | ||||||
| dc.contributor.author | Yew, DTW | ||||||
| dc.contributor.author | He, ML | ||||||
| dc.contributor.author | Lin, MCM | ||||||
| dc.contributor.author | Leung, PC | ||||||
| dc.contributor.author | Kung, HF | ||||||
| dc.date.accessioned | 2010-09-06T06:18:10Z | ||||||
| dc.date.available | 2010-09-06T06:18:10Z | ||||||
| dc.date.issued | 2010 | ||||||
| dc.description.abstract | Fructus Ligustri Lucidi (FLL) has been used in traditional Chinese medicine for over 1000 years. The ethanol extract of FLL (EFLL) has been shown to be a potential candidate in the prevention and treatment of osteoporosis. The present study aimed to determine whether EFLL carries out the effect by promoting osteogenesis in mesenchymal stem cells (MSCs). The osteogenic differentiation of MSCs was evaluated by their alkaline phosphatase (ALP) activities and mineralization. Expression of genes was detected by RT-PCR. We found that EFLL significantly stimulated the ALP activities and shortened the time needed for the mineralization of MSCs during osteogenic differentiation. The expression of several osteoblast differentiation regulators was also upregulated by EFLL during this process. Our study demonstrated that the EFLL is capable of enhancing osteogenic differentiation of MSCs. It might be useful for treating diseases with inadequate bone formation, including osteoporosis. Copyright © 2009 John Wiley & Sons, Ltd. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Phytotherapy Research, 2010, v. 24 n. 4, p. 571-576 [How to Cite?] DOI: http://dx.doi.org/10.1002/ptr.2987 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1002/ptr.2987 | ||||||
| dc.identifier.epage | 576 | ||||||
| dc.identifier.hkuros | 167697 | ||||||
| dc.identifier.isi | WOS:000276802500017
Funding Information: The authors would like to thank bone marrow donors. We would also thank Dr David Wilmshurst for editing this paper. This work was supported by the Li Ka Shing Institute of Health Sciences Grant and RGC project: CUHK 7422_03M. | ||||||
| dc.identifier.issn | 0951-418X 2011 Impact Factor: 2.086 2011 SCImago Journal Rankings: 0.120 | ||||||
| dc.identifier.issue | 4 | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmid | 19813230 | ||||||
| dc.identifier.scopus | eid_2-s2.0-77951542282 | ||||||
| dc.identifier.spage | 571 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/69932 | ||||||
| dc.identifier.volume | 24 | ||||||
| dc.language | eng | ||||||
| dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567 | ||||||
| dc.publisher.place | United Kingdom | ||||||
| dc.relation.ispartof | Phytotherapy Research | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | Phytotherapy Research. Copyright © John Wiley & Sons Ltd. | ||||||
| dc.rights | The definitive version is available at www.3.interscience.wiley.com | ||||||
| dc.subject.mesh | Bone Density Conservation Agents - analysis | ||||||
| dc.subject.mesh | Ligustrum - chemistry | ||||||
| dc.subject.mesh | Mesenchymal Stem Cells - drug effects - metabolism | ||||||
| dc.subject.mesh | Osteogenesis - drug effects | ||||||
| dc.subject.mesh | Plant Extracts - pharmacology | ||||||
| dc.subject | Bone marrow | ||||||
| dc.subject | Fructus ligustri lucidi | ||||||
| dc.subject | Mesenchymal stem cells | ||||||
| dc.subject | Osteogenesis | ||||||
| dc.title | Ethanol extract of Fructus Ligustri Lucidi promotes osteogenesis of mesenchymal stem cells | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- Chinese University of Hong Kong