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Article: Novel gadolinium(III) polyaminocarboxylate macrocyclic complexes as potential magnetic resonance imaging contrast agents

TitleNovel gadolinium(III) polyaminocarboxylate macrocyclic complexes as potential magnetic resonance imaging contrast agents
Authors
KeywordsContrast agent
Gadolinium
Macrocycle
Magnetic resonance imaging
Polyaminocarboxylate
Issue Date2004
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jinorgbio
Citation
Journal Of Inorganic Biochemistry, 2004, v. 98 n. 5, p. 677-682 How to Cite?
AbstractTwo novel Gd(III) complexes with functionalised polyaminocarboxylate macrocycles, 1,4,7-tris(carboxymethyl)-9,24-dioxo-14,19-dioxa-1,4,7,10,23- pentaazacyclododecane (L 1) and 1,4,7-tris(carboxymethyl)-9,25-dioxo- 14,17,20-trioxa-1,4,7,10,23- pentaazacyclotridecane (L 2), were prepared in good yield. Their potential use as magnetic resonance imaging (MRI) contrast agents (CAs) was evaluated by investigating their relaxation behaviour as a function of pH, temperature and magnetic field strength. The 1/T 1 proton relaxivities at 20 MHz and 25°C of GdL 1 (5.87 mM -1 s -1) and GdL 2 (6.14 mM -1 s -1) were found to be significantly higher than the clinically used Gd 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Gd(DOTA) -) and Gd diethylenetriaminepentaethanoic acid (Gd(DTPA) 2-). The complexes possess one water molecule in the inner coordination sphere whose mean residence lifetime was estimated to be 1.1 and 1.5 μs at 25°C by variable temperature (VT) 17O NMR spectroscopy. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/69888
ISSN
2015 Impact Factor: 3.205
2015 SCImago Journal Rankings: 0.983
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KWYen_HK
dc.contributor.authorBarra, Sen_HK
dc.contributor.authorBotta, Men_HK
dc.contributor.authorWong, WTen_HK
dc.date.accessioned2010-09-06T06:17:45Z-
dc.date.available2010-09-06T06:17:45Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Inorganic Biochemistry, 2004, v. 98 n. 5, p. 677-682en_HK
dc.identifier.issn0162-0134en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69888-
dc.description.abstractTwo novel Gd(III) complexes with functionalised polyaminocarboxylate macrocycles, 1,4,7-tris(carboxymethyl)-9,24-dioxo-14,19-dioxa-1,4,7,10,23- pentaazacyclododecane (L 1) and 1,4,7-tris(carboxymethyl)-9,25-dioxo- 14,17,20-trioxa-1,4,7,10,23- pentaazacyclotridecane (L 2), were prepared in good yield. Their potential use as magnetic resonance imaging (MRI) contrast agents (CAs) was evaluated by investigating their relaxation behaviour as a function of pH, temperature and magnetic field strength. The 1/T 1 proton relaxivities at 20 MHz and 25°C of GdL 1 (5.87 mM -1 s -1) and GdL 2 (6.14 mM -1 s -1) were found to be significantly higher than the clinically used Gd 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Gd(DOTA) -) and Gd diethylenetriaminepentaethanoic acid (Gd(DTPA) 2-). The complexes possess one water molecule in the inner coordination sphere whose mean residence lifetime was estimated to be 1.1 and 1.5 μs at 25°C by variable temperature (VT) 17O NMR spectroscopy. © 2004 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jinorgbioen_HK
dc.relation.ispartofJournal of Inorganic Biochemistryen_HK
dc.rightsJournal of Inorganic Biochemistry. Copyright © Elsevier Inc.en_HK
dc.subjectContrast agenten_HK
dc.subjectGadoliniumen_HK
dc.subjectMacrocycleen_HK
dc.subjectMagnetic resonance imagingen_HK
dc.subjectPolyaminocarboxylateen_HK
dc.titleNovel gadolinium(III) polyaminocarboxylate macrocyclic complexes as potential magnetic resonance imaging contrast agentsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0162-0134&volume=98&spage=677&epage=682&date=2004&atitle=Novel+gadolinium(III)+polyaminocarboxylate+macrocyclic+complexes+as+potential+magnetic+resonance+imaging+contrast+agentsen_HK
dc.identifier.emailWong, WT: wtwong@hku.hken_HK
dc.identifier.authorityWong, WT=rp00811en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jinorgbio.2004.02.008en_HK
dc.identifier.pmid15134912-
dc.identifier.scopuseid_2-s2.0-2342665614en_HK
dc.identifier.hkuros91838en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2342665614&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume98en_HK
dc.identifier.issue5en_HK
dc.identifier.spage677en_HK
dc.identifier.epage682en_HK
dc.identifier.isiWOS:000221678300003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, KWY=35763564900en_HK
dc.identifier.scopusauthoridBarra, S=7006103309en_HK
dc.identifier.scopusauthoridBotta, M=22955486900en_HK
dc.identifier.scopusauthoridWong, WT=7403973084en_HK

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