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Article: Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/β-catenin signaling pathway

TitleFlavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/β-catenin signaling pathway
Authors
KeywordsBMP signaling pathway
Flavonoids of Herb Epidemium
Mesenchymal stem cells
Osteogenic differentiation
Wnt/β-catenin signaling pathway
Issue Date2010
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mce
Citation
Molecular And Cellular Endocrinology, 2010, v. 314 n. 1, p. 70-74 How to Cite?
AbstractHerba Epimedii is one of the most commonly used Chinese herbs for treating osteoporosis. In the present study, the flavonoids of Herba Epimedii (HEF) have shown to promote the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. They were noted to enhance the mRNA expression of BMP-2, BMP-4, Runx2, β-catenin and cyclinD1, all of which are BMP or Wnt-signaling pathway related regulators. The osteogenic effect was inhibited by the introduction of noggin and DKK-1, which is classical inhibitor of BMP and Wnt/β-catenin signaling, respectively. These results suggest that HEF exerts promoting effect on osteogenic differentiation, which plausibly functions via the BMP and Wnt/β-catenin signaling pathways. Considering the therapeutic efficiency and economical issues, HEF may be a potential candidate for promoting bone regeneration. On the other hand, osteogenic differentiation of MSCs may also be a promising and attractive tool to apply in bone repair. © 2009.
Persistent Identifierhttp://hdl.handle.net/10722/69871
ISSN
2015 Impact Factor: 3.859
2015 SCImago Journal Rankings: 2.116
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Jfen_HK
dc.contributor.authorLi, Gen_HK
dc.contributor.authorChan, Cyen_HK
dc.contributor.authorMeng, Clen_HK
dc.contributor.authorLin, MCmen_HK
dc.contributor.authorChen, Ycen_HK
dc.contributor.authorHe, Mlen_HK
dc.contributor.authorLeung, Pcen_HK
dc.contributor.authorKung, Hfen_HK
dc.date.accessioned2010-09-06T06:17:36Z-
dc.date.available2010-09-06T06:17:36Z-
dc.date.issued2010en_HK
dc.identifier.citationMolecular And Cellular Endocrinology, 2010, v. 314 n. 1, p. 70-74en_HK
dc.identifier.issn0303-7207en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69871-
dc.description.abstractHerba Epimedii is one of the most commonly used Chinese herbs for treating osteoporosis. In the present study, the flavonoids of Herba Epimedii (HEF) have shown to promote the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. They were noted to enhance the mRNA expression of BMP-2, BMP-4, Runx2, β-catenin and cyclinD1, all of which are BMP or Wnt-signaling pathway related regulators. The osteogenic effect was inhibited by the introduction of noggin and DKK-1, which is classical inhibitor of BMP and Wnt/β-catenin signaling, respectively. These results suggest that HEF exerts promoting effect on osteogenic differentiation, which plausibly functions via the BMP and Wnt/β-catenin signaling pathways. Considering the therapeutic efficiency and economical issues, HEF may be a potential candidate for promoting bone regeneration. On the other hand, osteogenic differentiation of MSCs may also be a promising and attractive tool to apply in bone repair. © 2009.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mceen_HK
dc.relation.ispartofMolecular and Cellular Endocrinologyen_HK
dc.rightsMolecular and Cellular Endocrinology. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectBMP signaling pathwayen_HK
dc.subjectFlavonoids of Herb Epidemiumen_HK
dc.subjectMesenchymal stem cellsen_HK
dc.subjectOsteogenic differentiationen_HK
dc.subjectWnt/β-catenin signaling pathwayen_HK
dc.titleFlavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/β-catenin signaling pathwayen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0303-7207&volume=314&issue=1&spage=70&epage=74&date=2009&atitle=Flavonoids+of+Herba+Epimedii+Regulate+Osteogenesis+of+Human+Mesenchymal+Stem+Cells+Through+BMP+and+Wnt/β-catenin+Signaling+Pathwayen_HK
dc.identifier.emailLin, MCm:mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLin, MCm=rp00746en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.mce.2009.08.012en_HK
dc.identifier.pmid19703516-
dc.identifier.scopuseid_2-s2.0-70350532232en_HK
dc.identifier.hkuros163222en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350532232&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume314en_HK
dc.identifier.issue1en_HK
dc.identifier.spage70en_HK
dc.identifier.epage74en_HK
dc.identifier.isiWOS:000272101700008-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridZhang, Jf=17347152100en_HK
dc.identifier.scopusauthoridLi, G=7407055832en_HK
dc.identifier.scopusauthoridChan, Cy=22033276600en_HK
dc.identifier.scopusauthoridMeng, Cl=36927269600en_HK
dc.identifier.scopusauthoridLin, MCm=7404816359en_HK
dc.identifier.scopusauthoridChen, Yc=24075600300en_HK
dc.identifier.scopusauthoridHe, Ml=35080389700en_HK
dc.identifier.scopusauthoridLeung, Pc=7401747829en_HK
dc.identifier.scopusauthoridKung, Hf=7402514190en_HK
dc.identifier.citeulike5671620-

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