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Article: Direct trapping of acrylamide as a key mechanism for niacin's inhibitory activity in carcinogenic acrylamide formation

TitleDirect trapping of acrylamide as a key mechanism for niacin's inhibitory activity in carcinogenic acrylamide formation
Authors
Issue Date2010
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/crt
Citation
Chemical Research In Toxicology, 2010, v. 23 n. 4, p. 802-807 How to Cite?
AbstractThe inhibitory mechanism of niacin, which was found in our previous study to effectively reduce acrylamide (AA) formation in both chemical models and fried potato strips, was investigated in the present study. Maillard chemical models containing the amino acid asparagine and glucose with or without niacin were closely examined by liquid chromatography/tandem mass spectrometry. Comparison of the chemical profiles revealed two additional peaks in models where niacin was present together with the AA precursors, which thus suggests the formation of compounds from reactions between niacin and other chemical species in the model systems. The predicted molecular weights of these two analytes were consistent with adducts formed between niacin and asparagine or AA, respectively. The niacin-acrylamide adduct was also detected in fried potato strips pretreated with niacin. In addition, the niacin-acrylamide adduct was subsequently purified and characterized by NMR spectroscopy as 1-propanamide-3-carboxy pyridinium, a novel compound that has never been reported previously. Furthermore, incubation of niacin with AA in simulated physiological conditions showed that niacin was capable of significantly reducing the level of AA. Findings from this study suggest that niacin not only has the potential to remove AA from food products during heat treatment by directly trapping it but also is a potential agent to scavenge AA in human body. © 2010 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/69719
ISSN
2015 Impact Factor: 3.025
2015 SCImago Journal Rankings: 1.323
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZeng, Xen_HK
dc.contributor.authorKong, RPWen_HK
dc.contributor.authorCheng, KWen_HK
dc.contributor.authorDu, Yen_HK
dc.contributor.authorTang, YSen_HK
dc.contributor.authorChu, IKen_HK
dc.contributor.authorLo, Cen_HK
dc.contributor.authorSze, KHen_HK
dc.contributor.authorChen, Fen_HK
dc.contributor.authorWang, Men_HK
dc.date.accessioned2010-09-06T06:16:13Z-
dc.date.available2010-09-06T06:16:13Z-
dc.date.issued2010en_HK
dc.identifier.citationChemical Research In Toxicology, 2010, v. 23 n. 4, p. 802-807en_HK
dc.identifier.issn0893-228Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/69719-
dc.description.abstractThe inhibitory mechanism of niacin, which was found in our previous study to effectively reduce acrylamide (AA) formation in both chemical models and fried potato strips, was investigated in the present study. Maillard chemical models containing the amino acid asparagine and glucose with or without niacin were closely examined by liquid chromatography/tandem mass spectrometry. Comparison of the chemical profiles revealed two additional peaks in models where niacin was present together with the AA precursors, which thus suggests the formation of compounds from reactions between niacin and other chemical species in the model systems. The predicted molecular weights of these two analytes were consistent with adducts formed between niacin and asparagine or AA, respectively. The niacin-acrylamide adduct was also detected in fried potato strips pretreated with niacin. In addition, the niacin-acrylamide adduct was subsequently purified and characterized by NMR spectroscopy as 1-propanamide-3-carboxy pyridinium, a novel compound that has never been reported previously. Furthermore, incubation of niacin with AA in simulated physiological conditions showed that niacin was capable of significantly reducing the level of AA. Findings from this study suggest that niacin not only has the potential to remove AA from food products during heat treatment by directly trapping it but also is a potential agent to scavenge AA in human body. © 2010 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/crten_HK
dc.relation.ispartofChemical Research in Toxicologyen_HK
dc.rightsChemical Research in Toxicology. Copyright © American Chemical Society.-
dc.subject.meshAcrylamide - chemistry - toxicity-
dc.subject.meshAcrylamides - analysis - chemistry-
dc.subject.meshAsparagine - chemistry-
dc.subject.meshCarcinogens - chemistry - toxicity-
dc.subject.meshNiacin - analogs and derivatives - analysis - chemistry - metabolism-
dc.titleDirect trapping of acrylamide as a key mechanism for niacin's inhibitory activity in carcinogenic acrylamide formationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0893-228X&volume=23&issue=4&spage=802&epage=807&date=2010&atitle=Direct+trapping+of+acrylamide+as+a+key+mechanism+for+Niacin%27s+inhibitory+activity+in+carcinogenic+acrylamide+formationen_HK
dc.identifier.emailChu, IK: ivankchu@hku.hken_HK
dc.identifier.emailLo, C: clivelo@hkucc.hku.hken_HK
dc.identifier.emailSze, KH: khsze@hku.hken_HK
dc.identifier.emailChen, F: sfchen@hku.hken_HK
dc.identifier.emailWang, M: mfwang@hku.hken_HK
dc.identifier.authorityChu, IK=rp00683en_HK
dc.identifier.authorityLo, C=rp00751en_HK
dc.identifier.authoritySze, KH=rp00785en_HK
dc.identifier.authorityChen, F=rp00672en_HK
dc.identifier.authorityWang, M=rp00800en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/tx900438zen_HK
dc.identifier.pmid20235591-
dc.identifier.scopuseid_2-s2.0-77951235646en_HK
dc.identifier.hkuros169751en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951235646&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue4en_HK
dc.identifier.spage802en_HK
dc.identifier.epage807en_HK
dc.identifier.isiWOS:000276691800015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZeng, X=35760592200en_HK
dc.identifier.scopusauthoridKong, RPW=35217869000en_HK
dc.identifier.scopusauthoridCheng, KW=12141247000en_HK
dc.identifier.scopusauthoridDu, Y=35725386400en_HK
dc.identifier.scopusauthoridTang, YS=36246612700en_HK
dc.identifier.scopusauthoridChu, IK=7103327484en_HK
dc.identifier.scopusauthoridLo, C=15737175700en_HK
dc.identifier.scopusauthoridSze, KH=7006735061en_HK
dc.identifier.scopusauthoridChen, F=7404907980en_HK
dc.identifier.scopusauthoridWang, M=7406691844en_HK

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