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Article: Synthesis and cytotoxicity studies of artemisinin derivatives containing lipophilic alkyl carbon chains

TitleSynthesis and cytotoxicity studies of artemisinin derivatives containing lipophilic alkyl carbon chains
Authors
Issue Date2005
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html
Citation
Organic Letters, 2005, v. 7 n. 8, p. 1561-1564 How to Cite?
Abstract(Chemical Equation Presented) Cytotoxic artemisinin derivatives have been synthesized by a modular approach of "artemisinin + linker + lipophilic alkyl carbon chain". A strong correlation between the length of the carbon chains and the cytotoxicities against human hepatocellular carcinoma (HepG2) was revealed. Notably, compared with artemisinin (IC50 = 97 μM), up to 200-fold more potent cytotoxicity (IC50 = 0.46 μM) could be achieved by attachment of a C14H29 carbon chain to artemisinin via an amide linker. © 2005 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/69666
ISSN
2015 Impact Factor: 6.732
2015 SCImago Journal Rankings: 3.187
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorWong, VKWen_HK
dc.contributor.authorKo, BCBen_HK
dc.contributor.authorWong, MKen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2010-09-06T06:15:45Z-
dc.date.available2010-09-06T06:15:45Z-
dc.date.issued2005en_HK
dc.identifier.citationOrganic Letters, 2005, v. 7 n. 8, p. 1561-1564en_HK
dc.identifier.issn1523-7060en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69666-
dc.description.abstract(Chemical Equation Presented) Cytotoxic artemisinin derivatives have been synthesized by a modular approach of "artemisinin + linker + lipophilic alkyl carbon chain". A strong correlation between the length of the carbon chains and the cytotoxicities against human hepatocellular carcinoma (HepG2) was revealed. Notably, compared with artemisinin (IC50 = 97 μM), up to 200-fold more potent cytotoxicity (IC50 = 0.46 μM) could be achieved by attachment of a C14H29 carbon chain to artemisinin via an amide linker. © 2005 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.htmlen_HK
dc.relation.ispartofOrganic Lettersen_HK
dc.titleSynthesis and cytotoxicity studies of artemisinin derivatives containing lipophilic alkyl carbon chainsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1523-7060&volume=7&spage=1561&epage=1564&date=2005&atitle=Synthesis+and+cytotoxicity+studies+of+artemisinin+derivatives+containing+lipophilic+alkyl+carbon+chainsen_HK
dc.identifier.emailLiu, Y:lyg100@hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authorityLiu, Y=rp00749en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ol050230oen_HK
dc.identifier.pmid15816752-
dc.identifier.scopuseid_2-s2.0-17844362433en_HK
dc.identifier.hkuros100049en_HK
dc.identifier.hkuros148218-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17844362433&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1561en_HK
dc.identifier.epage1564en_HK
dc.identifier.isiWOS:000228344200032-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, Y=8225912600en_HK
dc.identifier.scopusauthoridWong, VKW=8541929000en_HK
dc.identifier.scopusauthoridKo, BCB=7102833927en_HK
dc.identifier.scopusauthoridWong, MK=7403908449en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK

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