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Article: Complexation of antimony(III) by trypanothione

TitleComplexation of antimony(III) by trypanothione
Authors
KeywordsAntimony
Bioinorganic chemistry
NMR spectroscopy
Issue Date2000
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
Citation
Angewandte Chemie - International Edition, 2000, v. 39 n. 23, p. 4260-4262 How to Cite?
AbstractAntimonial antileishmanial drugs may owe their activity to the formation of a 1:1 complex between Sb and trypanothione - A glutathione/spermidine conjugate that is essential for the growth and survival of trypanosomatid protozoan parasites such as Leishmania. On the basis of the MS and 2D NMR data of the complex, a structure is proposed in which a Sb(III) ion is bound to the S atoms of cysteine residues, and the coordination sphere of Sb is completed by the oxygen atom of a water molecule (O(W); see picture).
Persistent Identifierhttp://hdl.handle.net/10722/69657
ISSN
2015 Impact Factor: 11.709
2015 SCImago Journal Rankings: 6.229
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYan, Sen_HK
dc.contributor.authorDing, Ken_HK
dc.contributor.authorZhang, Len_HK
dc.contributor.authorSun, Hen_HK
dc.date.accessioned2010-09-06T06:15:40Z-
dc.date.available2010-09-06T06:15:40Z-
dc.date.issued2000en_HK
dc.identifier.citationAngewandte Chemie - International Edition, 2000, v. 39 n. 23, p. 4260-4262en_HK
dc.identifier.issn1433-7851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69657-
dc.description.abstractAntimonial antileishmanial drugs may owe their activity to the formation of a 1:1 complex between Sb and trypanothione - A glutathione/spermidine conjugate that is essential for the growth and survival of trypanosomatid protozoan parasites such as Leishmania. On the basis of the MS and 2D NMR data of the complex, a structure is proposed in which a Sb(III) ion is bound to the S atoms of cysteine residues, and the coordination sphere of Sb is completed by the oxygen atom of a water molecule (O(W); see picture).en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/homeen_HK
dc.relation.ispartofAngewandte Chemie - International Editionen_HK
dc.subjectAntimonyen_HK
dc.subjectBioinorganic chemistryen_HK
dc.subjectNMR spectroscopyen_HK
dc.titleComplexation of antimony(III) by trypanothioneen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1433-7851&volume=39&issue=23&spage=4260&epage=4262&date=2000&atitle=Complexation+of+antimony(III)+by+trypanothioneen_HK
dc.identifier.emailSun, H:hsun@hkucc.hku.hken_HK
dc.identifier.authoritySun, H=rp00777en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/1521-3773(20001201)39:23<4260::AID-ANIE4260>3.0.CO;2-9en_HK
dc.identifier.scopuseid_2-s2.0-0034605938en_HK
dc.identifier.hkuros58750en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034605938&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue23en_HK
dc.identifier.spage4260en_HK
dc.identifier.epage4262en_HK
dc.identifier.isiWOS:000165747500012-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridYan, S=7401744858en_HK
dc.identifier.scopusauthoridDing, K=7103197872en_HK
dc.identifier.scopusauthoridZhang, L=8085225300en_HK
dc.identifier.scopusauthoridSun, H=7404827446en_HK

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