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Article: Biocoordination chemistry of bismuth: Recent advances

TitleBiocoordination chemistry of bismuth: Recent advances
Authors
KeywordsBismuth
Cancer
Enzyme
Protein
Ulcer
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ccr
Citation
Coordination Chemistry Reviews, 2007, v. 251 n. 17-20, p. 2354-2366 How to Cite?
AbstractBismuth compounds have been widely used in the clinic for centuries because of their high effectiveness and low toxicity in the treatment of a variety of microbial infections, including syphilis, diarrhea, gastritis and colitis. The efficacy of recently developed bismuth-based triple therapy in the eradication of Helicobacter pylori from patients exceeded the normal PPI-based (proton pump inhibitor-based) therapies. Apart from antimicrobial activity, bismuth compounds exhibit anticancer activities, 212Bi and 213Bi compounds have also been used as targeted radio-therapeutic agents for cancer treatment, and furthermore they have the ability to reduce the side-effects of cisplatin in cancer therapy. The investigation of bismuth interactions with potential targeting biomolecules, including peptides, proteins and enzymes will lead to an understanding of the mechanism of action of bismuth-containing complexes and in turn to the further application of bismuth in medicine. © 2007 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/69550
ISSN
2015 Impact Factor: 12.994
2015 SCImago Journal Rankings: 4.100
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, Nen_HK
dc.contributor.authorSun, Hen_HK
dc.date.accessioned2010-09-06T06:14:42Z-
dc.date.available2010-09-06T06:14:42Z-
dc.date.issued2007en_HK
dc.identifier.citationCoordination Chemistry Reviews, 2007, v. 251 n. 17-20, p. 2354-2366en_HK
dc.identifier.issn0010-8545en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69550-
dc.description.abstractBismuth compounds have been widely used in the clinic for centuries because of their high effectiveness and low toxicity in the treatment of a variety of microbial infections, including syphilis, diarrhea, gastritis and colitis. The efficacy of recently developed bismuth-based triple therapy in the eradication of Helicobacter pylori from patients exceeded the normal PPI-based (proton pump inhibitor-based) therapies. Apart from antimicrobial activity, bismuth compounds exhibit anticancer activities, 212Bi and 213Bi compounds have also been used as targeted radio-therapeutic agents for cancer treatment, and furthermore they have the ability to reduce the side-effects of cisplatin in cancer therapy. The investigation of bismuth interactions with potential targeting biomolecules, including peptides, proteins and enzymes will lead to an understanding of the mechanism of action of bismuth-containing complexes and in turn to the further application of bismuth in medicine. © 2007 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ccren_HK
dc.relation.ispartofCoordination Chemistry Reviewsen_HK
dc.rightsCoordination Chemistry Reviews. Copyright © Elsevier BV.en_HK
dc.subjectBismuthen_HK
dc.subjectCanceren_HK
dc.subjectEnzymeen_HK
dc.subjectProteinen_HK
dc.subjectUlceren_HK
dc.titleBiocoordination chemistry of bismuth: Recent advancesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0010-8545&volume=251&spage=2354&epage=2366&date=2007&atitle=Biocoordination+chemistry+of+bismuth:+recent+advancesen_HK
dc.identifier.emailSun, H:hsun@hkucc.hku.hken_HK
dc.identifier.authoritySun, H=rp00777en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ccr.2007.03.003en_HK
dc.identifier.scopuseid_2-s2.0-34548543539en_HK
dc.identifier.hkuros167631en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548543539&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume251en_HK
dc.identifier.issue17-20en_HK
dc.identifier.spage2354en_HK
dc.identifier.epage2366en_HK
dc.identifier.isiWOS:000250605400015-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridYang, N=36633600500en_HK
dc.identifier.scopusauthoridSun, H=7404827446en_HK

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