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Article: Capillary electrophoresis for the determination of albumin binding capacity and free bilirubin in jaundiced neonates

TitleCapillary electrophoresis for the determination of albumin binding capacity and free bilirubin in jaundiced neonates
Authors
Issue Date2001
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/semperi
Citation
Seminars In Perinatology, 2001, v. 25 n. 2, p. 50-54 How to Cite?
AbstractThis study develops a capillary electrophoresis/frontal analysis (CE/FA) method to separate free bilirubin from its albumin bound complex, with only small-sized samples. Under our optimized conditions, CE/FA is proven to be a simple and accurate method in assaying the concentration of free bilirubin in the jaundiced serum. Upon saturation of albumin-binding, the amount of bilirubin added to the serum bears a linear relationship with the absorbance at OD44OnM (R = .9987, P < .00001). Application of this method to study jaundiced neonates has yielded precise data on the residual binding capacity, which may be of significant therapeutic implications. The CE/FA method we have developed appears to be promising and applicable for clinical use as it is highly reproducible and it only requires a small sample size for tests. Our method should be an invaluable adjunct to the neonatal management of hyperbilirubinaemia. Copyright © 2001 by W.B. Saunders Company.
Persistent Identifierhttp://hdl.handle.net/10722/69498
ISSN
2015 Impact Factor: 2.131
2015 SCImago Journal Rankings: 1.131
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYeung, CYen_HK
dc.contributor.authorFung, YSen_HK
dc.contributor.authorSun, DXen_HK
dc.date.accessioned2010-09-06T06:14:13Z-
dc.date.available2010-09-06T06:14:13Z-
dc.date.issued2001en_HK
dc.identifier.citationSeminars In Perinatology, 2001, v. 25 n. 2, p. 50-54en_HK
dc.identifier.issn0146-0005en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69498-
dc.description.abstractThis study develops a capillary electrophoresis/frontal analysis (CE/FA) method to separate free bilirubin from its albumin bound complex, with only small-sized samples. Under our optimized conditions, CE/FA is proven to be a simple and accurate method in assaying the concentration of free bilirubin in the jaundiced serum. Upon saturation of albumin-binding, the amount of bilirubin added to the serum bears a linear relationship with the absorbance at OD44OnM (R = .9987, P < .00001). Application of this method to study jaundiced neonates has yielded precise data on the residual binding capacity, which may be of significant therapeutic implications. The CE/FA method we have developed appears to be promising and applicable for clinical use as it is highly reproducible and it only requires a small sample size for tests. Our method should be an invaluable adjunct to the neonatal management of hyperbilirubinaemia. Copyright © 2001 by W.B. Saunders Company.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/semperien_HK
dc.relation.ispartofSeminars in Perinatologyen_HK
dc.titleCapillary electrophoresis for the determination of albumin binding capacity and free bilirubin in jaundiced neonatesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0146-0005&volume=25&issue=20&spage=50&epage=54&date=2001&atitle=Capillary+electrophoresis+for+the+determination+of+albumin+binding+capacity+and+free+bilirubin+in+jaundiced+neonatesen_HK
dc.identifier.emailFung, YS:ysfung@hku.hken_HK
dc.identifier.authorityFung, YS=rp00697en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11339664-
dc.identifier.scopuseid_2-s2.0-0035058952en_HK
dc.identifier.hkuros62498en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035058952&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue2en_HK
dc.identifier.spage50en_HK
dc.identifier.epage54en_HK
dc.identifier.isiWOS:000168272000002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYeung, CY=7201354144en_HK
dc.identifier.scopusauthoridFung, YS=13309754700en_HK
dc.identifier.scopusauthoridSun, DX=36788445000en_HK

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