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Article: Coordination chemistry of metals in medicine: Target sites for bismuth

TitleCoordination chemistry of metals in medicine: Target sites for bismuth
Authors
KeywordsAnti-ulcer
Bioinorganic chemistry
Bismuth
Metallodrugs
Issue Date1999
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ccr
Citation
Coordination Chemistry Reviews, 1999, v. 185-186, p. 689-709 How to Cite?
AbstractBismuth compounds are used for the treatment of gastrointestinal disorders and may also be useful for the treatment of other diseases. Bi(III) exhibits a highly variable coordination number (3-10) and often an irregular coordination geometry. The coordination chemistry of Bi(III) with carboxylates and aminocarboxylates is dominated by intermolecular interactions which leads to polymeric structures. Bi(III) binds strongly to the thiolate sulfur of the tripeptide glutathione, however these adducts are also kinetically labile which allows rapid translocation of Bi(III) inside cells. The major biological target for Bi(III) appears to be proteins and enzymes. Bi(III) binds to both Zn(II) sites (e.g. metallothionein) and Fe(III) sites (e.g. transferrin and lactoferrin) in proteins and enzymes and inhibits the bacterial Ni enzyme urease. © 1999 Elsevier Science S.A. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/69486
ISSN
2015 Impact Factor: 12.994
2015 SCImago Journal Rankings: 4.100
References

 

DC FieldValueLanguage
dc.contributor.authorSadler, PJen_HK
dc.contributor.authorLi, Hen_HK
dc.contributor.authorSun, Hen_HK
dc.date.accessioned2010-09-06T06:14:06Z-
dc.date.available2010-09-06T06:14:06Z-
dc.date.issued1999en_HK
dc.identifier.citationCoordination Chemistry Reviews, 1999, v. 185-186, p. 689-709en_HK
dc.identifier.issn0010-8545en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69486-
dc.description.abstractBismuth compounds are used for the treatment of gastrointestinal disorders and may also be useful for the treatment of other diseases. Bi(III) exhibits a highly variable coordination number (3-10) and often an irregular coordination geometry. The coordination chemistry of Bi(III) with carboxylates and aminocarboxylates is dominated by intermolecular interactions which leads to polymeric structures. Bi(III) binds strongly to the thiolate sulfur of the tripeptide glutathione, however these adducts are also kinetically labile which allows rapid translocation of Bi(III) inside cells. The major biological target for Bi(III) appears to be proteins and enzymes. Bi(III) binds to both Zn(II) sites (e.g. metallothionein) and Fe(III) sites (e.g. transferrin and lactoferrin) in proteins and enzymes and inhibits the bacterial Ni enzyme urease. © 1999 Elsevier Science S.A. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ccren_HK
dc.relation.ispartofCoordination Chemistry Reviewsen_HK
dc.rightsCoordination Chemistry Reviews. Copyright © Elsevier BV.en_HK
dc.subjectAnti-ulceren_HK
dc.subjectBioinorganic chemistryen_HK
dc.subjectBismuthen_HK
dc.subjectMetallodrugsen_HK
dc.titleCoordination chemistry of metals in medicine: Target sites for bismuthen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0010-8545&volume=185-186&spage=689&epage=709&date=1999&atitle=Coordination+chemistry+of+metals+in+medicine:+target+sites+for+bismuthen_HK
dc.identifier.emailSun, H:hsun@hkucc.hku.hken_HK
dc.identifier.authoritySun, H=rp00777en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0033416920en_HK
dc.identifier.hkuros43979en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033416920&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume185-186en_HK
dc.identifier.spage689en_HK
dc.identifier.epage709en_HK
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridSadler, PJ=7103024488en_HK
dc.identifier.scopusauthoridLi, H=14023043100en_HK
dc.identifier.scopusauthoridSun, H=7404827446en_HK

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