File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro

TitleGold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro
Authors
KeywordsCell migration
Gold(III) porphyrin 1a
Invasion
Metastasis
Nasopharyngeal carcinoma (NPC)
Issue Date2010
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2010, v. 294 n. 2, p. 159-166 How to Cite?
Abstract
A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. © 2010 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/69441
ISSN
2013 Impact Factor: 5.016
ISI Accession Number ID
Funding AgencyGrant Number
AoE Scheme of UGCAoE/P-10/01
RGC of the Hong Kong Special Administrative Region, ChinaHKU7705/07
Funding Information:

This study was supported by grants from the AoE Scheme of UGC (AoE/P-10/01) and RGC (HKU7705/07 M to MCL) of the Hong Kong Special Administrative Region, China.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLum, CTen_HK
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorLi, XPen_HK
dc.contributor.authorPeng, Yen_HK
dc.contributor.authorHe, MLen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorLin, MCMen_HK
dc.date.accessioned2010-09-06T06:13:41Z-
dc.date.available2010-09-06T06:13:41Z-
dc.date.issued2010en_HK
dc.identifier.citationCancer Letters, 2010, v. 294 n. 2, p. 159-166en_HK
dc.identifier.issn0304-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69441-
dc.description.abstractA physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. © 2010 Elsevier Ireland Ltd.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_HK
dc.relation.ispartofCancer Lettersen_HK
dc.subjectCell migrationen_HK
dc.subjectGold(III) porphyrin 1aen_HK
dc.subjectInvasionen_HK
dc.subjectMetastasisen_HK
dc.subjectNasopharyngeal carcinoma (NPC)en_HK
dc.subject.meshCell Movement - drug effects-
dc.subject.meshGold - pharmacology-
dc.subject.meshMetalloporphyrins - pharmacology-
dc.subject.meshNasopharyngeal Neoplasms - blood supply - drug therapy - enzymology - pathology-
dc.subject.meshRNA, Messenger - biosynthesis - genetics-
dc.titleGold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitroen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3835&volume=294&issue=2&spage=159&epage=166&date=2010&atitle=Gold(III)+porphyrin+1a+inhibited+nasopharyngeal+carcinoma+metastasis+in+vivo+and+inhibited+cell+migration+and+invasion+in+vitroen_HK
dc.identifier.emailLum, CT:ctlum@graduate.hku.hken_HK
dc.identifier.emailSun, RWY:rwysun@hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLum, CT=rp00757en_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2010.01.033en_HK
dc.identifier.pmid20163914en_HK
dc.identifier.scopuseid_2-s2.0-77953363272en_HK
dc.identifier.hkuros169000en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953363272&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume294en_HK
dc.identifier.issue2en_HK
dc.identifier.spage159en_HK
dc.identifier.epage166en_HK
dc.identifier.isiWOS:000279064700004-
dc.publisher.placeIrelanden_HK
dc.relation.projectInstitute of molecular technology for drug discovery and synthesis-
dc.identifier.scopusauthoridLum, CT=7006889374en_HK
dc.identifier.scopusauthoridLiu, X=35303002700en_HK
dc.identifier.scopusauthoridSun, RWY=26325835800en_HK
dc.identifier.scopusauthoridLi, XP=26663939600en_HK
dc.identifier.scopusauthoridPeng, Y=35249237100en_HK
dc.identifier.scopusauthoridHe, ML=35080389700en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK
dc.identifier.citeulike6781380-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats