Article: Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro
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- Publisher Website: 10.1016/j.canlet.2010.01.033
- Scopus: eid_2-s2.0-77953363272
- PMID: 20163914
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| Title | Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro |
|---|---|
| Authors | Lum, CT2 Liu, X1 2 Sun, RWY2 Li, XP1 Peng, Y3 He, ML4 Kung, HF3 4 Che, CM2 Lin, MCM2 3 |
| Keywords | Cell migration Gold(III) porphyrin 1a Invasion Metastasis Nasopharyngeal carcinoma (NPC) |
| Issue Date | 2010 |
| Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet |
| Citation | Cancer Letters, 2010, v. 294 n. 2, p. 159-166 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.canlet.2010.01.033 |
| Abstract | A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. © 2010 Elsevier Ireland Ltd. |
| ISSN | 0304-3835 2011 Impact Factor: 4.238 2011 SCImago Journal Rankings: 0.494 |
| DOI | http://dx.doi.org/10.1016/j.canlet.2010.01.033 |
| References | References in Scopus |
| Grants | Institute of molecular technology for drug discovery and synthesis |
| dc.contributor.author | Lum, CT | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Liu, X | ||||||
| dc.contributor.author | Sun, RWY | ||||||
| dc.contributor.author | Li, XP | ||||||
| dc.contributor.author | Peng, Y | ||||||
| dc.contributor.author | He, ML | ||||||
| dc.contributor.author | Kung, HF | ||||||
| dc.contributor.author | Che, CM | ||||||
| dc.contributor.author | Lin, MCM | ||||||
| dc.date.accessioned | 2010-09-06T06:13:41Z | ||||||
| dc.date.available | 2010-09-06T06:13:41Z | ||||||
| dc.date.issued | 2010 | ||||||
| dc.description.abstract | A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. © 2010 Elsevier Ireland Ltd. | ||||||
| dc.description.grant | Institute of molecular technology for drug discovery and synthesis | ||||||
| dc.description.grantcode | 8708 | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Cancer Letters, 2010, v. 294 n. 2, p. 159-166 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.canlet.2010.01.033 | ||||||
| dc.identifier.citeulike | 6781380 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.canlet.2010.01.033 | ||||||
| dc.identifier.epage | 166 | ||||||
| dc.identifier.hkuros | 169000 | ||||||
| dc.identifier.isi | WOS:000279064700004
Funding Information: This study was supported by grants from the AoE Scheme of UGC (AoE/P-10/01) and RGC (HKU7705/07 M to MCL) of the Hong Kong Special Administrative Region, China. | ||||||
| dc.identifier.issn | 0304-3835 2011 Impact Factor: 4.238 2011 SCImago Journal Rankings: 0.494 | ||||||
| dc.identifier.issue | 2 | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmid | 20163914 | ||||||
| dc.identifier.scopus | eid_2-s2.0-77953363272 | ||||||
| dc.identifier.spage | 159 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/69441 | ||||||
| dc.identifier.volume | 294 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet | ||||||
| dc.publisher.place | Ireland | ||||||
| dc.relation.ispartof | Cancer Letters | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject.mesh | Cell Movement - drug effects | ||||||
| dc.subject.mesh | Gold - pharmacology | ||||||
| dc.subject.mesh | Metalloporphyrins - pharmacology | ||||||
| dc.subject.mesh | Nasopharyngeal Neoplasms - blood supply - drug therapy - enzymology - pathology | ||||||
| dc.subject.mesh | RNA, Messenger - biosynthesis - genetics | ||||||
| dc.subject | Cell migration | ||||||
| dc.subject | Gold(III) porphyrin 1a | ||||||
| dc.subject | Invasion | ||||||
| dc.subject | Metastasis | ||||||
| dc.subject | Nasopharyngeal carcinoma (NPC) | ||||||
| dc.title | Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro | ||||||
| dc.type | Article |
Author Affiliations
- Nanfang Hospital
- The University of Hong Kong
- Sun Yat-Sen University
- Chinese University of Hong Kong