File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro
  • Basic View
  • Metadata View
  • XML View
TitleGold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro
 
AuthorsLum, CT2
Liu, X2 1
Sun, RWY2
Li, XP1
Peng, Y3
He, ML4
Kung, HF4 3
Che, CM2
Lin, MCM2 3
 
KeywordsCell migration
Gold(III) porphyrin 1a
Invasion
Metastasis
Nasopharyngeal carcinoma (NPC)
 
Issue Date2010
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
 
CitationCancer Letters, 2010, v. 294 n. 2, p. 159-166 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2010.01.033
 
AbstractA physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. © 2010 Elsevier Ireland Ltd.
 
ISSN0304-3835
2013 Impact Factor: 5.016
 
DOIhttp://dx.doi.org/10.1016/j.canlet.2010.01.033
 
ISI Accession Number IDWOS:000279064700004
Funding AgencyGrant Number
AoE Scheme of UGCAoE/P-10/01
RGC of the Hong Kong Special Administrative Region, ChinaHKU7705/07
Funding Information:

This study was supported by grants from the AoE Scheme of UGC (AoE/P-10/01) and RGC (HKU7705/07 M to MCL) of the Hong Kong Special Administrative Region, China.

 
ReferencesReferences in Scopus
 
GrantsInstitute of molecular technology for drug discovery and synthesis
 
DC FieldValue
dc.contributor.authorLum, CT
 
dc.contributor.authorLiu, X
 
dc.contributor.authorSun, RWY
 
dc.contributor.authorLi, XP
 
dc.contributor.authorPeng, Y
 
dc.contributor.authorHe, ML
 
dc.contributor.authorKung, HF
 
dc.contributor.authorChe, CM
 
dc.contributor.authorLin, MCM
 
dc.date.accessioned2010-09-06T06:13:41Z
 
dc.date.available2010-09-06T06:13:41Z
 
dc.date.issued2010
 
dc.description.abstractA physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. © 2010 Elsevier Ireland Ltd.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationCancer Letters, 2010, v. 294 n. 2, p. 159-166 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2010.01.033
 
dc.identifier.citeulike6781380
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.canlet.2010.01.033
 
dc.identifier.epage166
 
dc.identifier.hkuros169000
 
dc.identifier.isiWOS:000279064700004
Funding AgencyGrant Number
AoE Scheme of UGCAoE/P-10/01
RGC of the Hong Kong Special Administrative Region, ChinaHKU7705/07
Funding Information:

This study was supported by grants from the AoE Scheme of UGC (AoE/P-10/01) and RGC (HKU7705/07 M to MCL) of the Hong Kong Special Administrative Region, China.

 
dc.identifier.issn0304-3835
2013 Impact Factor: 5.016
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid20163914
 
dc.identifier.scopuseid_2-s2.0-77953363272
 
dc.identifier.spage159
 
dc.identifier.urihttp://hdl.handle.net/10722/69441
 
dc.identifier.volume294
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
 
dc.publisher.placeIreland
 
dc.relation.ispartofCancer Letters
 
dc.relation.projectInstitute of molecular technology for drug discovery and synthesis
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshCell Movement - drug effects
 
dc.subject.meshGold - pharmacology
 
dc.subject.meshMetalloporphyrins - pharmacology
 
dc.subject.meshNasopharyngeal Neoplasms - blood supply - drug therapy - enzymology - pathology
 
dc.subject.meshRNA, Messenger - biosynthesis - genetics
 
dc.subjectCell migration
 
dc.subjectGold(III) porphyrin 1a
 
dc.subjectInvasion
 
dc.subjectMetastasis
 
dc.subjectNasopharyngeal carcinoma (NPC)
 
dc.titleGold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Lum, CT</contributor.author>
<contributor.author>Liu, X</contributor.author>
<contributor.author>Sun, RWY</contributor.author>
<contributor.author>Li, XP</contributor.author>
<contributor.author>Peng, Y</contributor.author>
<contributor.author>He, ML</contributor.author>
<contributor.author>Kung, HF</contributor.author>
<contributor.author>Che, CM</contributor.author>
<contributor.author>Lin, MCM</contributor.author>
<date.accessioned>2010-09-06T06:13:41Z</date.accessioned>
<date.available>2010-09-06T06:13:41Z</date.available>
<date.issued>2010</date.issued>
<identifier.citation>Cancer Letters, 2010, v. 294 n. 2, p. 159-166</identifier.citation>
<identifier.issn>0304-3835</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/69441</identifier.uri>
<description.abstract>A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. &#169; 2010 Elsevier Ireland Ltd.</description.abstract>
<language>eng</language>
<publisher>Elsevier Ireland Ltd. The Journal&apos;s web site is located at http://www.elsevier.com/locate/canlet</publisher>
<relation.ispartof>Cancer Letters</relation.ispartof>
<subject>Cell migration</subject>
<subject>Gold(III) porphyrin 1a</subject>
<subject>Invasion</subject>
<subject>Metastasis</subject>
<subject>Nasopharyngeal carcinoma (NPC)</subject>
<subject.mesh>Cell Movement - drug effects</subject.mesh>
<subject.mesh>Gold - pharmacology</subject.mesh>
<subject.mesh>Metalloporphyrins - pharmacology</subject.mesh>
<subject.mesh>Nasopharyngeal Neoplasms - blood supply - drug therapy - enzymology - pathology</subject.mesh>
<subject.mesh>RNA, Messenger - biosynthesis - genetics</subject.mesh>
<title>Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0304-3835&amp;volume=294&amp;issue=2&amp;spage=159&amp;epage=166&amp;date=2010&amp;atitle=Gold(III)+porphyrin+1a+inhibited+nasopharyngeal+carcinoma+metastasis+in+vivo+and+inhibited+cell+migration+and+invasion+in+vitro</identifier.openurl>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1016/j.canlet.2010.01.033</identifier.doi>
<identifier.pmid>20163914</identifier.pmid>
<identifier.scopus>eid_2-s2.0-77953363272</identifier.scopus>
<identifier.hkuros>169000</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-77953363272&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>294</identifier.volume>
<identifier.issue>2</identifier.issue>
<identifier.spage>159</identifier.spage>
<identifier.epage>166</identifier.epage>
<identifier.isi>WOS:000279064700004</identifier.isi>
<publisher.place>Ireland</publisher.place>
<relation.project>Institute of molecular technology for drug discovery and synthesis</relation.project>
<identifier.citeulike>6781380</identifier.citeulike>
</item>
Author Affiliations
  1. Nanfang Hospital
  2. The University of Hong Kong
  3. Sun Yat-Sen University
  4. Chinese University of Hong Kong