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Article: Differential and critical roles of reactive oxygen species and reactive nitrogen species in alcohol-induced gene dysregulations and birth defects in Xenopus embryos

TitleDifferential and critical roles of reactive oxygen species and reactive nitrogen species in alcohol-induced gene dysregulations and birth defects in Xenopus embryos
Authors
KeywordsAscorbic acid
Catalase
Fetal alcohol syndrome
Peroxiredoxin
Reactive nitrogen species
Reactive oxygen species
Issue Date2007
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/nba
Citation
Neuroembryology And Aging, 2007, v. 4 n. 3, p. 155-161 How to Cite?
AbstractAlcohol is the most common teratogen in humans. Excessive alcohol consumption in pregnant women may lead to fetal alcohol syndrome (FAS), which is characterized by microcephaly, growth retardation, facial dysmorphology, and abnormalities in the central nervous system. Despite extensive studies, the molecular mechanisms underlying FAS remain unclear. To this end, we established a Xenopus laevis embryo model to study the effects of alcohol on fetal development. We will discuss the relationship between alcohol-induced oxidative and nitrosative stresses and their differential and critical roles in the downregulation of key developmental genes and birth defects in the X. laevis embryo model. Copyright © 2007 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/69333
ISSN
2011 SCImago Journal Rankings: 0.130
References

 

DC FieldValueLanguage
dc.contributor.authorNg, SSen_HK
dc.contributor.authorYang, PHen_HK
dc.contributor.authorCheng, Yen_HK
dc.contributor.authorPeng, Yen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorLin, MCen_HK
dc.date.accessioned2010-09-06T06:12:42Z-
dc.date.available2010-09-06T06:12:42Z-
dc.date.issued2007en_HK
dc.identifier.citationNeuroembryology And Aging, 2007, v. 4 n. 3, p. 155-161en_HK
dc.identifier.issn1661-3406en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69333-
dc.description.abstractAlcohol is the most common teratogen in humans. Excessive alcohol consumption in pregnant women may lead to fetal alcohol syndrome (FAS), which is characterized by microcephaly, growth retardation, facial dysmorphology, and abnormalities in the central nervous system. Despite extensive studies, the molecular mechanisms underlying FAS remain unclear. To this end, we established a Xenopus laevis embryo model to study the effects of alcohol on fetal development. We will discuss the relationship between alcohol-induced oxidative and nitrosative stresses and their differential and critical roles in the downregulation of key developmental genes and birth defects in the X. laevis embryo model. Copyright © 2007 S. Karger AG.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/nbaen_HK
dc.relation.ispartofNeuroembryology and Agingen_HK
dc.rightsNeuroembryology and Aging. Copyright © S Karger AG.en_HK
dc.subjectAscorbic aciden_HK
dc.subjectCatalaseen_HK
dc.subjectFetal alcohol syndromeen_HK
dc.subjectPeroxiredoxinen_HK
dc.subjectReactive nitrogen speciesen_HK
dc.subjectReactive oxygen speciesen_HK
dc.titleDifferential and critical roles of reactive oxygen species and reactive nitrogen species in alcohol-induced gene dysregulations and birth defects in Xenopus embryosen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1661-3406&volume=4&spage=155&epage=161&date=2007&atitle=Differential+and+Critical+Roles+of+Reactive+Oxygen+Species+and+Reactive+Nitrogen+Species+in+Alcohol-Induced+Gene+Dysregulations+and+Birth+Defects+in+Xenopus+Embryosen_HK
dc.identifier.emailNg, SS: ssmng@hku.hken_HK
dc.identifier.emailLin, MC: mcllin@hkucc.hku.hken_HK
dc.identifier.authorityNg, SS=rp00767en_HK
dc.identifier.authorityLin, MC=rp00746en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000109347en_HK
dc.identifier.scopuseid_2-s2.0-35648948316en_HK
dc.identifier.hkuros138486en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35648948316&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue3en_HK
dc.identifier.spage155en_HK
dc.identifier.epage161en_HK
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridNg, SS=7403358718en_HK
dc.identifier.scopusauthoridYang, PH=24340289000en_HK
dc.identifier.scopusauthoridCheng, Y=22950201700en_HK
dc.identifier.scopusauthoridPeng, Y=7403419265en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridLin, MC=7404816359en_HK

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