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Article: A selective one-step synthesis of tris N-alkylated cyclens
Title | A selective one-step synthesis of tris N-alkylated cyclens |
---|---|
Authors | |
Keywords | Alkylation Cyclen One-step synthesis |
Issue Date | 2004 |
Publisher | Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/tet |
Citation | Tetrahedron, 2004, v. 60 n. 26, p. 5595-5601 How to Cite? |
Abstract | A general one-step synthesis for tris N-alkylated cyclens with good yield and unprecedented selectivity is presented. Tris and 1,4-bis N-alkylated cyclens, as the only two major products are isolated. Furthermore, according to the single crystal X-ray structures of tris and 1,4-bis N-alkylated cyclen 1 and 1a, one nitrogen atom on the cyclen ring can be protonated under this reaction condition, which prevents its further alkylation, and gives rise to the regioselectivity ultimately. © 2004 Elsevier Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/69236 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.406 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, C | en_HK |
dc.contributor.author | Wong, WT | en_HK |
dc.date.accessioned | 2010-09-06T06:11:49Z | - |
dc.date.available | 2010-09-06T06:11:49Z | - |
dc.date.issued | 2004 | en_HK |
dc.identifier.citation | Tetrahedron, 2004, v. 60 n. 26, p. 5595-5601 | en_HK |
dc.identifier.issn | 0040-4020 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/69236 | - |
dc.description.abstract | A general one-step synthesis for tris N-alkylated cyclens with good yield and unprecedented selectivity is presented. Tris and 1,4-bis N-alkylated cyclens, as the only two major products are isolated. Furthermore, according to the single crystal X-ray structures of tris and 1,4-bis N-alkylated cyclen 1 and 1a, one nitrogen atom on the cyclen ring can be protonated under this reaction condition, which prevents its further alkylation, and gives rise to the regioselectivity ultimately. © 2004 Elsevier Ltd. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/tet | en_HK |
dc.relation.ispartof | Tetrahedron | en_HK |
dc.subject | Alkylation | en_HK |
dc.subject | Cyclen | en_HK |
dc.subject | One-step synthesis | en_HK |
dc.title | A selective one-step synthesis of tris N-alkylated cyclens | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0040-4020&volume=60&issue=26&spage=5595&epage=5601&date=2004&atitle=A+selective+one-step+synthesis+of+tris+n-alkylated+cyclens | en_HK |
dc.identifier.email | Wong, WT: wtwong@hku.hk | en_HK |
dc.identifier.authority | Wong, WT=rp00811 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.tet.2004.04.086 | en_HK |
dc.identifier.scopus | eid_2-s2.0-2942556819 | en_HK |
dc.identifier.hkuros | 91831 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-2942556819&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 60 | en_HK |
dc.identifier.issue | 26 | en_HK |
dc.identifier.spage | 5595 | en_HK |
dc.identifier.epage | 5601 | en_HK |
dc.identifier.isi | WOS:000222097400009 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Li, C=8521804400 | en_HK |
dc.identifier.scopusauthorid | Wong, WT=7403973084 | en_HK |
dc.identifier.issnl | 0040-4020 | - |