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Article: Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase i poisons

TitleCyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase i poisons
Authors
Issue Date2010
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2010, v. 46 n. 22, p. 3893-3895 How to Cite?
AbstractA panel of stable [Au(R-CNC)(N-heterocyclic carbene)]+ complexes displays prominent in vitro anticancer properties; [Au(CNC)(IMe)]CF 3SO3 (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model. © 2010 The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/69233
ISSN
2015 Impact Factor: 6.567
2015 SCImago Journal Rankings: 2.771
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
Area of Excellence SchemeAoE/P-10/01
Funding Information:

We acknowledge the support from the University of Hong Kong (University Development Fund) and the Area of Excellence Scheme (AoE/P-10/01) administered by the University Grants Committee (HKSAR, China).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorYan, JJen_HK
dc.contributor.authorChow, ALFen_HK
dc.contributor.authorLeung, CHen_HK
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorMa, DLen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2010-09-06T06:11:47Z-
dc.date.available2010-09-06T06:11:47Z-
dc.date.issued2010en_HK
dc.identifier.citationChemical Communications, 2010, v. 46 n. 22, p. 3893-3895en_HK
dc.identifier.issn1359-7345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69233-
dc.description.abstractA panel of stable [Au(R-CNC)(N-heterocyclic carbene)]+ complexes displays prominent in vitro anticancer properties; [Au(CNC)(IMe)]CF 3SO3 (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model. © 2010 The Royal Society of Chemistry.en_HK
dc.languageengen_HK
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.aspen_HK
dc.relation.ispartofChemical Communicationsen_HK
dc.subject.meshAntineoplastic Agents - chemistry - therapeutic use - toxicity-
dc.subject.meshCoordination Complexes - chemistry - therapeutic use - toxicity-
dc.subject.meshGold - chemistry-
dc.subject.meshHeterocyclic Compounds - chemistry-
dc.subject.meshMethane - analogs and derivatives - chemistry-
dc.titleCyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase i poisonsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1359-7345&volume=46&issue=22&spage=3893&epage=3895&date=2010&atitle=Cyclometalated+gold(III)+complexes+with+N-heterocyclic+carbene+ligands+as+topoisomerase+I+poisonsen_HK
dc.identifier.emailLeung, CH:duncanl@hkucc.hku.hken_HK
dc.identifier.emailSun, RWY:rwysun@hku.hken_HK
dc.identifier.emailMa, DL:edmondma@hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authorityLeung, CH=rp00730en_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.identifier.authorityMa, DL=rp00760en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c001216een_HK
dc.identifier.pmid20401423-
dc.identifier.scopuseid_2-s2.0-77952771593en_HK
dc.identifier.hkuros169875en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952771593&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue22en_HK
dc.identifier.spage3893en_HK
dc.identifier.epage3895en_HK
dc.identifier.isiWOS:000278045700014-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectInstitute of molecular technology for drug discovery and synthesis-
dc.identifier.scopusauthoridYan, JJ=35752634300en_HK
dc.identifier.scopusauthoridChow, ALF=36463401100en_HK
dc.identifier.scopusauthoridLeung, CH=7402612570en_HK
dc.identifier.scopusauthoridSun, RWY=26325835800en_HK
dc.identifier.scopusauthoridMa, DL=7402075538en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK

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