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Article: Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening

TitleIdentification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening
Authors
Issue Date2010
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2010, v. 46 n. 26, p. 4680-4682 How to Cite?
AbstractFonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure. © 2010 The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/69219
ISSN
2015 Impact Factor: 6.567
2015 SCImago Journal Rankings: 2.771
ISI Accession Number ID
Funding AgencyGrant Number
University Grants Committee Hong Kong Special Administrative Region, ChinaAoE/P-10/01
University of Hong Kong
Funding Information:

This work is supported by the Area of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE/P-10/01), the University of Hong Kong (University Development Fund), the University of Hong Kong Seed Funding Programme for Applied Research, and the University of Hong Kong Seed Funding Programme for Basic Research.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLee, HMen_HK
dc.contributor.authorChan, DSHen_HK
dc.contributor.authorYang, Fen_HK
dc.contributor.authorLam, HYen_HK
dc.contributor.authorYan, SCen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorMa, DLen_HK
dc.contributor.authorLeung, CHen_HK
dc.date.accessioned2010-09-06T06:11:39Z-
dc.date.available2010-09-06T06:11:39Z-
dc.date.issued2010en_HK
dc.identifier.citationChemical Communications, 2010, v. 46 n. 26, p. 4680-4682en_HK
dc.identifier.issn1359-7345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69219-
dc.description.abstractFonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure. © 2010 The Royal Society of Chemistry.en_HK
dc.languageengen_HK
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.aspen_HK
dc.relation.ispartofChemical Communicationsen_HK
dc.subject.meshBiological Products - chemistry - pharmacology-
dc.subject.meshDNA - chemistry-
dc.subject.meshG-Quadruplexes-
dc.subject.meshHeterocyclic Compounds, 3-Ring - chemistry - pharmacology-
dc.subject.meshProto-Oncogene Proteins c-myc - genetics-
dc.titleIdentification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screeningen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1359-7345&volume=46&issue=26&spage=4680&epage=4682&date=2010&atitle=Identification+of+natural+product+Fonsecin+B+as+a+stabilizing+ligand+of+c-myc+G-quadruplex+DNA+by+high-throughput+virtual+screeningen_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.emailMa, DL:edmondma@hku.hken_HK
dc.identifier.emailLeung, CH:duncanl@hkucc.hku.hken_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authorityMa, DL=rp00760en_HK
dc.identifier.authorityLeung, CH=rp00730en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/b926359den_HK
dc.identifier.pmid20383387-
dc.identifier.scopuseid_2-s2.0-77953901414en_HK
dc.identifier.hkuros169874en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953901414&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue26en_HK
dc.identifier.spage4680en_HK
dc.identifier.epage4682en_HK
dc.identifier.isiWOS:000279045800003-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectInstitute of molecular technology for drug discovery and synthesis-
dc.identifier.scopusauthoridLee, HM=35754627100en_HK
dc.identifier.scopusauthoridChan, DSH=35285471900en_HK
dc.identifier.scopusauthoridYang, F=13405459600en_HK
dc.identifier.scopusauthoridLam, HY=36552832900en_HK
dc.identifier.scopusauthoridYan, SC=7401744858en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridMa, DL=7402075538en_HK
dc.identifier.scopusauthoridLeung, CH=7402612570en_HK
dc.identifier.citeulike7019277-

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