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Article: Unique scanning capabilities of a new hybrid linear ion trap mass spectrometer (Q TRAP) used for high sensitivity proteomics applications

TitleUnique scanning capabilities of a new hybrid linear ion trap mass spectrometer (Q TRAP) used for high sensitivity proteomics applications
Authors
KeywordsLinear ion trap
Liquid chromatography
Mass spectrometry
Phosphopeptide
Protein digest
Issue Date2003
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomics
Citation
Proteomics, 2003, v. 3 n. 6, p. 859-869 How to Cite?
AbstractThe unique scanning capabilities of a hybrid linear ion trap (Q TRAP) mass spectrometer are described with an emphasis on proteomics applications. The combination of the very selective triple quadrupole based tandem mass spectrometry (MS/MS) scans with the very sensitive ion trap product ion scans allows rapid identification of peptides at low concentrations derived from post-translationally modified proteins on chromatographic time scales. The Q TRAP instrument also offers the opportunity to conduct a variety of ion processing steps prior to performing a mass scan. For example, the enhancement of the multiple-charge ion contents of the ion trap can be performed resulting in a survey mass spectrum dominated by double- and triple-charge peptides. This facilitates the identification of relevant biological species in both separated and unseparated peptide mixtures for further MS/MS experiments.
Persistent Identifierhttp://hdl.handle.net/10722/69083
ISSN
2015 Impact Factor: 4.079
2015 SCImago Journal Rankings: 1.476
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLe Blanc, JCYen_HK
dc.contributor.authorHager, JWen_HK
dc.contributor.authorIlisiu, AMPen_HK
dc.contributor.authorHunter, Cen_HK
dc.contributor.authorZhong, Fen_HK
dc.contributor.authorChu, Ien_HK
dc.date.accessioned2010-09-06T06:10:24Z-
dc.date.available2010-09-06T06:10:24Z-
dc.date.issued2003en_HK
dc.identifier.citationProteomics, 2003, v. 3 n. 6, p. 859-869en_HK
dc.identifier.issn1615-9853en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69083-
dc.description.abstractThe unique scanning capabilities of a hybrid linear ion trap (Q TRAP) mass spectrometer are described with an emphasis on proteomics applications. The combination of the very selective triple quadrupole based tandem mass spectrometry (MS/MS) scans with the very sensitive ion trap product ion scans allows rapid identification of peptides at low concentrations derived from post-translationally modified proteins on chromatographic time scales. The Q TRAP instrument also offers the opportunity to conduct a variety of ion processing steps prior to performing a mass scan. For example, the enhancement of the multiple-charge ion contents of the ion trap can be performed resulting in a survey mass spectrum dominated by double- and triple-charge peptides. This facilitates the identification of relevant biological species in both separated and unseparated peptide mixtures for further MS/MS experiments.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomicsen_HK
dc.relation.ispartofProteomicsen_HK
dc.subjectLinear ion trapen_HK
dc.subjectLiquid chromatographyen_HK
dc.subjectMass spectrometryen_HK
dc.subjectPhosphopeptideen_HK
dc.subjectProtein digesten_HK
dc.titleUnique scanning capabilities of a new hybrid linear ion trap mass spectrometer (Q TRAP) used for high sensitivity proteomics applicationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1615-9853&volume=3&spage=859&epage=869&date=2003&atitle=Unique+scanning+capabilities+of+a+new+hybrid+linear+ion+trap+mass+spectrometer+(Q+TRAP)+used+for+high+sensitivity+proteomics+applicationsen_HK
dc.identifier.emailChu, I:ivankchu@hku.hken_HK
dc.identifier.authorityChu, I=rp00683en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/pmic.200300415en_HK
dc.identifier.pmid12833509-
dc.identifier.scopuseid_2-s2.0-0037709383en_HK
dc.identifier.hkuros76865en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037709383&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue6en_HK
dc.identifier.spage859en_HK
dc.identifier.epage869en_HK
dc.identifier.isiWOS:000183924600008-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridLe Blanc, JCY=7003449294en_HK
dc.identifier.scopusauthoridHager, JW=7101717899en_HK
dc.identifier.scopusauthoridIlisiu, AMP=6507379715en_HK
dc.identifier.scopusauthoridHunter, C=7202704353en_HK
dc.identifier.scopusauthoridZhong, F=22037230700en_HK
dc.identifier.scopusauthoridChu, I=7103327484en_HK

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