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Article: New Luminescent Cyclometalated Iridium(III) Diimine Complexes as Biological Labeling Reagents

TitleNew Luminescent Cyclometalated Iridium(III) Diimine Complexes as Biological Labeling Reagents
Authors
Issue Date2003
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/ic
Citation
Inorganic Chemistry, 2003, v. 42 n. 21, p. 6886-6897 How to Cite?
AbstractWe report the synthesis, characterization, and photophysical and electrochemical properties of thirty luminescent cyclometalated iridium(III) diimine complexes [Ir(N-C)2(N-N)](PF6) (HN-C = 2-phenylpyridine, Hppy; 2-(4-methylphenyl)pyridine, Hmppy; 3-methyl-1-phenylpyrazole, Hmppz; 7,8-benzoquinoline, Hbzq; 2-phenylquinoline, Hpq; N-N = 4-amino-2,2′-bipyridine, bpy-NH2; 4-isothiocyanato-2,2′-bipyridine, bpy-ITC; 4-iodoacetamido-2,2′ -bipyridine, bpy-IAA; 5-amino-1, 10-phenanthroline, phen-NH2; 5-isothiocyanato-1,10-phenanthroline, phen-ITC; 5-iodoacetamido-1, 10-phenanthroline, phen-IAA). The X-ray crystal structure of [Ir(mppz) 2(bpy-NH2)](PF6) has also been investigated. Upon irradiation, all the complexes display intense and long-lived luminescence under ambient conditions and in 77-K glass. On the basis of the photophysical and electrochemical data, the emission of most of these complexes is assigned to an excited state of predominantly triplet metal-to-ligand charge-transfer (3MLCT) (dπ(Ir) → π*(N-N)) character. In some cases, triplet intraligand (3IL) (π → π*)(N-N or N-C -) excited states have also been identified. In view of the specific reactivity of the isothiocyanate and iodoacetamide moieties toward the primary amine and sulfhydryl groups, respectively, we have labeled various biological molecules with a selection of these luminescent iridium(III) complexes. The photophysical properties of the luminescent conjugates have been investigated. In addition, a heterogeneous assay for digoxin has also been designed on the basis of the recognition of biotinylated antidigoxin by avidin labeled with one of the luminescent iridium(III) complexes.
Persistent Identifierhttp://hdl.handle.net/10722/69050
ISSN
2015 Impact Factor: 4.82
2015 SCImago Journal Rankings: 1.873
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLo, KKWen_HK
dc.contributor.authorChung, CKen_HK
dc.contributor.authorLee, TKMen_HK
dc.contributor.authorLui, LHen_HK
dc.contributor.authorTsang, KHKen_HK
dc.contributor.authorZhu, Nen_HK
dc.date.accessioned2010-09-06T06:10:05Z-
dc.date.available2010-09-06T06:10:05Z-
dc.date.issued2003en_HK
dc.identifier.citationInorganic Chemistry, 2003, v. 42 n. 21, p. 6886-6897en_HK
dc.identifier.issn0020-1669en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69050-
dc.description.abstractWe report the synthesis, characterization, and photophysical and electrochemical properties of thirty luminescent cyclometalated iridium(III) diimine complexes [Ir(N-C)2(N-N)](PF6) (HN-C = 2-phenylpyridine, Hppy; 2-(4-methylphenyl)pyridine, Hmppy; 3-methyl-1-phenylpyrazole, Hmppz; 7,8-benzoquinoline, Hbzq; 2-phenylquinoline, Hpq; N-N = 4-amino-2,2′-bipyridine, bpy-NH2; 4-isothiocyanato-2,2′-bipyridine, bpy-ITC; 4-iodoacetamido-2,2′ -bipyridine, bpy-IAA; 5-amino-1, 10-phenanthroline, phen-NH2; 5-isothiocyanato-1,10-phenanthroline, phen-ITC; 5-iodoacetamido-1, 10-phenanthroline, phen-IAA). The X-ray crystal structure of [Ir(mppz) 2(bpy-NH2)](PF6) has also been investigated. Upon irradiation, all the complexes display intense and long-lived luminescence under ambient conditions and in 77-K glass. On the basis of the photophysical and electrochemical data, the emission of most of these complexes is assigned to an excited state of predominantly triplet metal-to-ligand charge-transfer (3MLCT) (dπ(Ir) → π*(N-N)) character. In some cases, triplet intraligand (3IL) (π → π*)(N-N or N-C -) excited states have also been identified. In view of the specific reactivity of the isothiocyanate and iodoacetamide moieties toward the primary amine and sulfhydryl groups, respectively, we have labeled various biological molecules with a selection of these luminescent iridium(III) complexes. The photophysical properties of the luminescent conjugates have been investigated. In addition, a heterogeneous assay for digoxin has also been designed on the basis of the recognition of biotinylated antidigoxin by avidin labeled with one of the luminescent iridium(III) complexes.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/icen_HK
dc.relation.ispartofInorganic Chemistryen_HK
dc.titleNew Luminescent Cyclometalated Iridium(III) Diimine Complexes as Biological Labeling Reagentsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0020-1669&volume=42&issue=21&spage=6886&epage=6897&date=2003&atitle=New+luminescent+cyclometalated+iridium(III)+diimine+complexes+as+biological+labeling+reagentsen_HK
dc.identifier.emailZhu, N: nzhu@hkucc.hku.hken_HK
dc.identifier.authorityZhu, N=rp00845en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ic0346984en_HK
dc.identifier.pmid14552640-
dc.identifier.scopuseid_2-s2.0-0142072139en_HK
dc.identifier.hkuros91267en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0142072139&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume42en_HK
dc.identifier.issue21en_HK
dc.identifier.spage6886en_HK
dc.identifier.epage6897en_HK
dc.identifier.isiWOS:000186023900037-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLo, KKW=26032181200en_HK
dc.identifier.scopusauthoridChung, CK=7403613700en_HK
dc.identifier.scopusauthoridLee, TKM=8610515400en_HK
dc.identifier.scopusauthoridLui, LH=7005315682en_HK
dc.identifier.scopusauthoridTsang, KHK=8549213500en_HK
dc.identifier.scopusauthoridZhu, N=7201449530en_HK

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