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Article: DNA diagnosis by capillary electrophoresis and microfabricated electrophoretic devices

TitleDNA diagnosis by capillary electrophoresis and microfabricated electrophoretic devices
Authors
KeywordsCapillary electrophoresis
DNA diagnosis
Microchip
Microfluidic
Mutation
SNP
STRs
Issue Date2003
PublisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/erm
Citation
Expert Review Of Molecular Diagnostics, 2003, v. 3 n. 3, p. 387-394 How to Cite?
AbstractDNA diagnosis is experiencing an impressive progression towards the development of novel technology to identity various clinically relevant categories of genetic changes ad to meet the exponential growth of genomics. The introduction of capillary electrophoresis has dramatically accelerated the completion of the first draft of the human DNA sequence in the Human Genome Project, and thus, has become the method of choice for analysis of various genetic variants. The recent development of microfabricated electrophoretic devices has led to the possibility of integrating multiple sample handling with the actual measurement steps required for automation of molecular diagnostics. This review highlights the most recent progress in capillary electrophoresis and electrophoretic microdevices for DNA-based diagnostics, including the important areas of genotyping for point mutation, single nucleotide polymorphisms, short tandem repeats and organism identification. The application of these techniques for infectious and genetic disease diagnosis, as well as forensic identification purpose, are covered. The promising development and the challenges for techinical problems are also discussed.
Persistent Identifierhttp://hdl.handle.net/10722/69049
ISSN
2015 Impact Factor: 3.333
2015 SCImago Journal Rankings: 0.942
References

 

DC FieldValueLanguage
dc.contributor.authorQin, Jen_HK
dc.contributor.authorFung, Yen_HK
dc.contributor.authorLin, Ben_HK
dc.date.accessioned2010-09-06T06:10:05Z-
dc.date.available2010-09-06T06:10:05Z-
dc.date.issued2003en_HK
dc.identifier.citationExpert Review Of Molecular Diagnostics, 2003, v. 3 n. 3, p. 387-394en_HK
dc.identifier.issn1473-7159en_HK
dc.identifier.urihttp://hdl.handle.net/10722/69049-
dc.description.abstractDNA diagnosis is experiencing an impressive progression towards the development of novel technology to identity various clinically relevant categories of genetic changes ad to meet the exponential growth of genomics. The introduction of capillary electrophoresis has dramatically accelerated the completion of the first draft of the human DNA sequence in the Human Genome Project, and thus, has become the method of choice for analysis of various genetic variants. The recent development of microfabricated electrophoretic devices has led to the possibility of integrating multiple sample handling with the actual measurement steps required for automation of molecular diagnostics. This review highlights the most recent progress in capillary electrophoresis and electrophoretic microdevices for DNA-based diagnostics, including the important areas of genotyping for point mutation, single nucleotide polymorphisms, short tandem repeats and organism identification. The application of these techniques for infectious and genetic disease diagnosis, as well as forensic identification purpose, are covered. The promising development and the challenges for techinical problems are also discussed.en_HK
dc.languageengen_HK
dc.publisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/ermen_HK
dc.relation.ispartofExpert Review of Molecular Diagnosticsen_HK
dc.subjectCapillary electrophoresisen_HK
dc.subjectDNA diagnosisen_HK
dc.subjectMicrochipen_HK
dc.subjectMicrofluidicen_HK
dc.subjectMutationen_HK
dc.subjectSNPen_HK
dc.subjectSTRsen_HK
dc.titleDNA diagnosis by capillary electrophoresis and microfabricated electrophoretic devicesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1473-7159&volume=3&issue=3&spage=387&epage=394&date=2003&atitle=DNA+diagnosis+by+capillary+electrophoresis+and+microfabricated+electrophoretic+devicesen_HK
dc.identifier.emailFung, Y:ysfung@hku.hken_HK
dc.identifier.authorityFung, Y=rp00697en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1586/14737159.3.3.387en_HK
dc.identifier.pmid12779012-
dc.identifier.scopuseid_2-s2.0-0038625256en_HK
dc.identifier.hkuros77199en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038625256&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue3en_HK
dc.identifier.spage387en_HK
dc.identifier.epage394en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridQin, J=36883013300en_HK
dc.identifier.scopusauthoridFung, Y=13309754700en_HK
dc.identifier.scopusauthoridLin, B=34668182800en_HK

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