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Article: Inhibition of human nasopharyngeal carcinoma growth and metastasis in mice by adenovirus-associated virus-mediated expression of human endostatin

TitleInhibition of human nasopharyngeal carcinoma growth and metastasis in mice by adenovirus-associated virus-mediated expression of human endostatin
Authors
Issue Date2006
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://mct.aacrjournals.org/
Citation
Molecular Cancer Therapeutics, 2006, v. 5 n. 5, p. 1290-1299 How to Cite?
AbstractNasopharyngeal carcinoma (NPC) is a highly malignant and frequently metastasized tumor. Endostatin has been shown to inhibit NPC growth, but its efficacy against NPC metastasis has not been shown in vivo. Here, we established a NPC metastasis model in mice by transplanting EBV-positive NPC cells, C666-1, in the livers of nude mice and observed lung metastasis. Furthermore, we showed that tall vein injection of recombinant adeno-associated virus encoding human endostatin (rAAV-hEndo) significantly prolonged the median survival rate of NPC metastasis-bearing mice (from 22 to 37 days, P < 0.01). The rAAV-hEndo treatment resulted in a statistically significant reduction in tumor growth and microvessel formation. It also increased the apoptotic index in the primary liver tumor but not in the normal liver tissue. Importantly, no formation of liver or lung metastasis was detected. The potent inhibition of NPC metastasis suggests the feasibility of combining rAAV-hEndo gene therapy with other therapies for the prevention and treatment of NPC metastasis. Copyright © 2006 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/68952
ISSN
2015 Impact Factor: 5.579
2015 SCImago Journal Rankings: 3.224
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, XPen_HK
dc.contributor.authorLi, CYSen_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorDing, Yen_HK
dc.contributor.authorChan, LLYen_HK
dc.contributor.authorYang, PHen_HK
dc.contributor.authorLi, Gen_HK
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorLin, JSen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorHe, Men_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorLin, MCen_HK
dc.contributor.authorPeng, Yen_HK
dc.date.accessioned2010-09-06T06:09:12Z-
dc.date.available2010-09-06T06:09:12Z-
dc.date.issued2006en_HK
dc.identifier.citationMolecular Cancer Therapeutics, 2006, v. 5 n. 5, p. 1290-1299en_HK
dc.identifier.issn1535-7163en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68952-
dc.description.abstractNasopharyngeal carcinoma (NPC) is a highly malignant and frequently metastasized tumor. Endostatin has been shown to inhibit NPC growth, but its efficacy against NPC metastasis has not been shown in vivo. Here, we established a NPC metastasis model in mice by transplanting EBV-positive NPC cells, C666-1, in the livers of nude mice and observed lung metastasis. Furthermore, we showed that tall vein injection of recombinant adeno-associated virus encoding human endostatin (rAAV-hEndo) significantly prolonged the median survival rate of NPC metastasis-bearing mice (from 22 to 37 days, P < 0.01). The rAAV-hEndo treatment resulted in a statistically significant reduction in tumor growth and microvessel formation. It also increased the apoptotic index in the primary liver tumor but not in the normal liver tissue. Importantly, no formation of liver or lung metastasis was detected. The potent inhibition of NPC metastasis suggests the feasibility of combining rAAV-hEndo gene therapy with other therapies for the prevention and treatment of NPC metastasis. Copyright © 2006 American Association for Cancer Research.en_HK
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://mct.aacrjournals.org/en_HK
dc.relation.ispartofMolecular Cancer Therapeuticsen_HK
dc.titleInhibition of human nasopharyngeal carcinoma growth and metastasis in mice by adenovirus-associated virus-mediated expression of human endostatinen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1535-7163&volume=5&spage=1290&epage=1298&date=2006&atitle=Inhibition+of+human+nasopharyngeal+carcinoma+growth+and+metastasis+in+mice+by+adenovirus-associated+virus-mediated+expression+of+human+endostatinen_HK
dc.identifier.emailWang, J: jidewang@gmail.comen_HK
dc.identifier.emailLin, MC: mcllin@hkucc.hku.hken_HK
dc.identifier.authorityWang, J=rp00491en_HK
dc.identifier.authorityLin, MC=rp00746en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1158/1535-7163.MCT-05-0348en_HK
dc.identifier.pmid16731762-
dc.identifier.scopuseid_2-s2.0-33745115864en_HK
dc.identifier.hkuros116319en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745115864&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1290en_HK
dc.identifier.epage1299en_HK
dc.identifier.isiWOS:000238073800023-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, XP=26663939600en_HK
dc.identifier.scopusauthoridLi, CYS=27171281900en_HK
dc.identifier.scopusauthoridLi, X=24511917000en_HK
dc.identifier.scopusauthoridDing, Y=7404137178en_HK
dc.identifier.scopusauthoridChan, LLY=32867597700en_HK
dc.identifier.scopusauthoridYang, PH=24340289000en_HK
dc.identifier.scopusauthoridLi, G=36013406300en_HK
dc.identifier.scopusauthoridLiu, X=35303002700en_HK
dc.identifier.scopusauthoridLin, JS=37054021300en_HK
dc.identifier.scopusauthoridWang, J=35309087500en_HK
dc.identifier.scopusauthoridHe, M=35080389700en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridLin, MC=7404816359en_HK
dc.identifier.scopusauthoridPeng, Y=7403419265en_HK

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