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Article: Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding

TitleLuminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding
Authors
Issue Date2005
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2005 n. 8, p. 1025-1027 How to Cite?
AbstractPt(C/N)(phe) (1, C/N = 2-(2′-thienyl)pyridine, phe = phenylalanine) shows a high binding affinity (ca. 106 dm3 mol -1) and selectivity towards human serum albumin (HSA) and such binding is accompanied by an enhancement of photoluminescence at 562 nm; both the protein binding affinity and cytotoxicities of [Pt(C/N)(phe) (1), Pt(C/N)(trp) (2, trp = tryptophan) and Pt(C/N)(gly) (3, gly = glycine)] are affected by the amino acid ligand with 1 having an IC50 of up to 1 μM against a number of carcinoma cell lines. © The Royal Society of Chemistry 2005.
Persistent Identifierhttp://hdl.handle.net/10722/68917
ISSN
2015 Impact Factor: 6.567
2015 SCImago Journal Rankings: 2.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSiu, PKMen_HK
dc.contributor.authorMa, DLen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2010-09-06T06:08:53Z-
dc.date.available2010-09-06T06:08:53Z-
dc.date.issued2005en_HK
dc.identifier.citationChemical Communications, 2005 n. 8, p. 1025-1027en_HK
dc.identifier.issn1359-7345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68917-
dc.description.abstractPt(C/N)(phe) (1, C/N = 2-(2′-thienyl)pyridine, phe = phenylalanine) shows a high binding affinity (ca. 106 dm3 mol -1) and selectivity towards human serum albumin (HSA) and such binding is accompanied by an enhancement of photoluminescence at 562 nm; both the protein binding affinity and cytotoxicities of [Pt(C/N)(phe) (1), Pt(C/N)(trp) (2, trp = tryptophan) and Pt(C/N)(gly) (3, gly = glycine)] are affected by the amino acid ligand with 1 having an IC50 of up to 1 μM against a number of carcinoma cell lines. © The Royal Society of Chemistry 2005.en_HK
dc.languageengen_HK
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.aspen_HK
dc.relation.ispartofChemical Communicationsen_HK
dc.titleLuminescent cyclometalated platinum(II) complexes with amino acid ligands for protein bindingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1359-7345&volume=&spage=1025&epage=1027&date=2005&atitle=Luminescent+cyclometalated+platinum(II)+complexes+with+amino+acid+ligands+for+protein+bindingen_HK
dc.identifier.emailMa, DL:edmondma@hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authorityMa, DL=rp00760en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/b414936jen_HK
dc.identifier.pmid15719104-
dc.identifier.scopuseid_2-s2.0-14944340145en_HK
dc.identifier.hkuros107052en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14944340145&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.issue8en_HK
dc.identifier.spage1025en_HK
dc.identifier.epage1027en_HK
dc.identifier.isiWOS:000227609700015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSiu, PKM=7004170705en_HK
dc.identifier.scopusauthoridMa, DL=7402075538en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK

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