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Article: Highly cytotoxic iron(II) complexes with pentadentate pyridyl ligands as a new class of anti-tumor agents

TitleHighly cytotoxic iron(II) complexes with pentadentate pyridyl ligands as a new class of anti-tumor agents
Authors
Issue Date2005
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2005 n. 36, p. 4578-4580 How to Cite?
AbstractThe iron(II) complexes 1a and 2 with pentadentate pyridyl ligands are stable under physiological conditions and exhibit higher cytotoxicities toward a series of human carcinoma cell lines than cisplatin; 1a can significantly increase intracellular oxidant levels, cleave supercoiled plasmid DNA in vitro without addition of a reductant and induce apoptotic cell death in human cervical epithelioid carcinoma cells (HeLa) as observed in flow cytometric studies. © The Royal Society of Chemistry 2005.
Persistent Identifierhttp://hdl.handle.net/10722/68916
ISSN
2015 Impact Factor: 6.567
2015 SCImago Journal Rankings: 2.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, ELMen_HK
dc.contributor.authorFang, GSen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorZhu, Nen_HK
dc.date.accessioned2010-09-06T06:08:53Z-
dc.date.available2010-09-06T06:08:53Z-
dc.date.issued2005en_HK
dc.identifier.citationChemical Communications, 2005 n. 36, p. 4578-4580en_HK
dc.identifier.issn1359-7345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68916-
dc.description.abstractThe iron(II) complexes 1a and 2 with pentadentate pyridyl ligands are stable under physiological conditions and exhibit higher cytotoxicities toward a series of human carcinoma cell lines than cisplatin; 1a can significantly increase intracellular oxidant levels, cleave supercoiled plasmid DNA in vitro without addition of a reductant and induce apoptotic cell death in human cervical epithelioid carcinoma cells (HeLa) as observed in flow cytometric studies. © The Royal Society of Chemistry 2005.en_HK
dc.languageengen_HK
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.aspen_HK
dc.relation.ispartofChemical Communicationsen_HK
dc.titleHighly cytotoxic iron(II) complexes with pentadentate pyridyl ligands as a new class of anti-tumor agentsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1359-7345&volume=&spage=4578&epage=4580&date=2005&atitle=Highly+cytotoxic+iron(II)+complexes+with+pentadentate+pyridyl+ligands+as+a+new+class+of+anti-tumor+agentsen_HK
dc.identifier.emailWong, ELM: wongella@hku.hken_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.emailZhu, N: nzhu@hkucc.hku.hken_HK
dc.identifier.authorityWong, ELM=rp00807en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authorityZhu, N=rp00845en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/b507687ken_HK
dc.identifier.pmid16158120-
dc.identifier.scopuseid_2-s2.0-26444614658en_HK
dc.identifier.hkuros117976en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-26444614658&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.issue36en_HK
dc.identifier.spage4578en_HK
dc.identifier.epage4580en_HK
dc.identifier.isiWOS:000231809200023-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, ELM=8944839700en_HK
dc.identifier.scopusauthoridFang, GS=7201871289en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridZhu, N=7201449530en_HK

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