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Article: Generation of peptide radical dications via low-energy collision-induced dissociation of [CuII(terpy)(M + H)].3+

TitleGeneration of peptide radical dications via low-energy collision-induced dissociation of [CuII(terpy)(M + H)].3+
Authors
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jasms
Citation
Journal Of The American Society For Mass Spectrometry, 2005, v. 16 n. 11, p. 1795-1804 How to Cite?
AbstractThe first example of the formation of hydrogen-deficient radical cations of the type [M + H].2+ is demonstrated to occur through a one-electron-transfer mechanism upon low-energy collision-induced dissociation (CID) of gas-phase triply charged [CuII(terpy)(M + H)].3+ complex ions (where M is an angiotensin III or enkephalin derivative; terpy = 2,2′:6′,2″-terpyridine). The collision-induced dissociation of doubly charged [M + H].2+ radical cations generates similar product ions to those prepared through hot electron capture dissociation (HECD). Isomeric isoleucine and leucine residues were distinguished by observing the mass differences between [zn + H].+ and wn + ions (having the same residue number, n) of the Xle residues. The product ion spectrum of [zn + H].+ reveals that the w n + ions are formed possibly from consecutive fragmentations of [zn + H].+ ions. Although only the first few [M + H].2+ species have been observed using this approach, these hydrogen-deficient radical cations produce fragment ions that have more structure-informative patterns and are very different from those formed during the low-energy tandem mass spectrometry of protonated peptides. © 2005 American Society for Mass Spectrometry.
Persistent Identifierhttp://hdl.handle.net/10722/68872
ISSN
2015 Impact Factor: 3.031
2015 SCImago Journal Rankings: 1.322
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChu, IKen_HK
dc.contributor.authorLam, CNWen_HK
dc.date.accessioned2010-09-06T06:08:29Z-
dc.date.available2010-09-06T06:08:29Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of The American Society For Mass Spectrometry, 2005, v. 16 n. 11, p. 1795-1804en_HK
dc.identifier.issn1044-0305en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68872-
dc.description.abstractThe first example of the formation of hydrogen-deficient radical cations of the type [M + H].2+ is demonstrated to occur through a one-electron-transfer mechanism upon low-energy collision-induced dissociation (CID) of gas-phase triply charged [CuII(terpy)(M + H)].3+ complex ions (where M is an angiotensin III or enkephalin derivative; terpy = 2,2′:6′,2″-terpyridine). The collision-induced dissociation of doubly charged [M + H].2+ radical cations generates similar product ions to those prepared through hot electron capture dissociation (HECD). Isomeric isoleucine and leucine residues were distinguished by observing the mass differences between [zn + H].+ and wn + ions (having the same residue number, n) of the Xle residues. The product ion spectrum of [zn + H].+ reveals that the w n + ions are formed possibly from consecutive fragmentations of [zn + H].+ ions. Although only the first few [M + H].2+ species have been observed using this approach, these hydrogen-deficient radical cations produce fragment ions that have more structure-informative patterns and are very different from those formed during the low-energy tandem mass spectrometry of protonated peptides. © 2005 American Society for Mass Spectrometry.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jasmsen_HK
dc.relation.ispartofJournal of the American Society for Mass Spectrometryen_HK
dc.rightsJournal of the American Society for Mass Spectrometry. Copyright © Elsevier Inc.en_HK
dc.titleGeneration of peptide radical dications via low-energy collision-induced dissociation of [CuII(terpy)(M + H)].3+en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1044-0305&volume=16&spage=1795&epage=1804&date=2005&atitle=Generation+of+peptide+radical+dications+via+low-energy+collision-induced+dissociation+of+[CuII(terpy)(M+H)]++++·3+en_HK
dc.identifier.emailChu, IK:ivankchu@hku.hken_HK
dc.identifier.authorityChu, IK=rp00683en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jasms.2005.06.015en_HK
dc.identifier.pmid16198598-
dc.identifier.scopuseid_2-s2.0-26944492647en_HK
dc.identifier.hkuros107563en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-26944492647&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1795en_HK
dc.identifier.epage1804en_HK
dc.identifier.isiWOS:000233095600010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChu, IK=7103327484en_HK
dc.identifier.scopusauthoridLam, CNW=7402990888en_HK

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