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Article: Cleft lip and/or palate in a low-resource province in China

TitleCleft lip and/or palate in a low-resource province in China
Authors
KeywordsBirth defects
Cleft lip and/or palate
Neonate
Perinatal period
Prevalence
Issue Date2006
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijgo
Citation
International Journal Of Gynecology And Obstetrics, 2006, v. 93 n. 2, p. 146-147 How to Cite?
AbstractCleft lip and/or palate (CLP) is a polygenically inherited defect, which means that its chance of recurrence within the same family is higher than in the general population. The pattern of inheritance is not decided by a pair of alleles. Rather, it is due to the combinational effect of several sets of genes within the environment. When the probability of inheriting a genetic disease is higher than 60%, this is considered a high chance of inheritance. The probability of inheriting CLP is 76%. Thus, it is advisable to seek genetic counseling before marriage or pregnancy to effectively minimize the prevalence of CLP within the Chinese society. Women from 28 weeks of pregnancy forward and their newborns until 7 days after birth were investigated at 17 hospitals in Guizhou province, China, whether the child was live-born or stillborn or whether fetal death had occurred. The study was conducted from January 1, 1996, until December 31, 2004. Over the 9-year study period, the mean overall prevalence of birth defects was 120.94 per 10,000 births, which was found to be statistically significant by the χ2 test (P < 0.001). Of all birth defects CLP was the most prevalent, with a mean prevalence of 22.63 per 10,000 births, which was statistically significant (P < 0.001). There was no obvious trend for change within these 9 years (Table 1). Nonsyndrome types accounted for 87.17% of CLP cases in Guizhou province, with a male-to-female ratio of 1.65:1.
Persistent Identifierhttp://hdl.handle.net/10722/68798
ISSN
2015 Impact Factor: 1.674
2015 SCImago Journal Rankings: 1.544
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Jen_HK
dc.contributor.authorHan, Yen_HK
dc.contributor.authorLin, MCen_HK
dc.date.accessioned2010-09-06T06:07:49Z-
dc.date.available2010-09-06T06:07:49Z-
dc.date.issued2006en_HK
dc.identifier.citationInternational Journal Of Gynecology And Obstetrics, 2006, v. 93 n. 2, p. 146-147en_HK
dc.identifier.issn0020-7292en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68798-
dc.description.abstractCleft lip and/or palate (CLP) is a polygenically inherited defect, which means that its chance of recurrence within the same family is higher than in the general population. The pattern of inheritance is not decided by a pair of alleles. Rather, it is due to the combinational effect of several sets of genes within the environment. When the probability of inheriting a genetic disease is higher than 60%, this is considered a high chance of inheritance. The probability of inheriting CLP is 76%. Thus, it is advisable to seek genetic counseling before marriage or pregnancy to effectively minimize the prevalence of CLP within the Chinese society. Women from 28 weeks of pregnancy forward and their newborns until 7 days after birth were investigated at 17 hospitals in Guizhou province, China, whether the child was live-born or stillborn or whether fetal death had occurred. The study was conducted from January 1, 1996, until December 31, 2004. Over the 9-year study period, the mean overall prevalence of birth defects was 120.94 per 10,000 births, which was found to be statistically significant by the χ2 test (P < 0.001). Of all birth defects CLP was the most prevalent, with a mean prevalence of 22.63 per 10,000 births, which was statistically significant (P < 0.001). There was no obvious trend for change within these 9 years (Table 1). Nonsyndrome types accounted for 87.17% of CLP cases in Guizhou province, with a male-to-female ratio of 1.65:1.-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijgoen_HK
dc.relation.ispartofInternational Journal of Gynecology and Obstetricsen_HK
dc.rightsInternational Journal of Gynecology & Obstetrics. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectBirth defectsen_HK
dc.subjectCleft lip and/or palateen_HK
dc.subjectNeonateen_HK
dc.subjectPerinatal perioden_HK
dc.subjectPrevalenceen_HK
dc.titleCleft lip and/or palate in a low-resource province in Chinaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0020-7292&volume=93&issue=2&spage=146&epage=7&date=2006&atitle=Cleft+lip+and/or+palate+in+a+low-resource+province+in+China.en_HK
dc.identifier.emailLin, MC:mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLin, MC=rp00746en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijgo.2006.01.025en_HK
dc.identifier.pmid16546187-
dc.identifier.scopuseid_2-s2.0-33646036158en_HK
dc.identifier.hkuros115451en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646036158&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume93en_HK
dc.identifier.issue2en_HK
dc.identifier.spage146en_HK
dc.identifier.epage147en_HK
dc.identifier.isiWOS:000237769800012-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLiu, J=24470507100en_HK
dc.identifier.scopusauthoridHan, Y=36168111300en_HK
dc.identifier.scopusauthoridLin, MC=7404816359en_HK

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