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Article: Structure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants

TitleStructure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants
Authors
KeywordsCoumarins
Flavonoids
Lignans
Phenolic acids
Phenolic compounds
Quinones
Radical scavenging activity
Stilbenes
Structure-activity relationships
Tannins
Traditional Chinese medicinal plants
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2006, v. 78 n. 25, p. 2872-2888 How to Cite?
Abstract
Traditional Chinese medicinal plants associated with anticancer contain a wide variety of natural phenolic compounds with various structural features and possessing widely differing antioxidant activity. The structure-radical scavenging activity relationships of a large number of representative phenolic compounds (e.g., flavanols, flavonols, chalcones, flavones, flavanones, isoflavones, tannins, stilbenes, curcuminoids, phenolic acids, coumarins, lignans, and quinones) identified in the traditional Chinese medicinal plants were evaluated using the improved ABTS •+ and DPPH methods. Different categories of tested phenolics showed significant mean differences in radical scavenging activity. Tannins demonstrated the strongest activity, while most quinones, isoflavones, and lignans tested showed the weakest activity. This study confirmed that the number and position of hydroxyl groups and the related glycosylation and other substitutions largely determined radical scavenging activity of the tested phenolic compounds. The differences in radical scavenging activity were attributed to structural differences in hydroxylation, glycosylation and methoxylation. The ortho-dihydroxy groups were the most important structural feature of high activity for all tested phenolic compounds. Other structural features played a modified role in enhancing or reducing the activity. Within each class of phenolic compounds, the structure-activity relationship was elucidated and discussed. This study reveals the structure-activity relationships of a large series of representative natural phenolic compounds more systematically and fully than previous work. Structure-radical scavenging activity relationships of some natural phenolics identified in the medicinal plants were evaluated for the first time. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68710
ISSN
2013 Impact Factor: 2.296
2013 SCImago Journal Rankings: 0.962
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Wuhan University
  3. Republic Polytechnic
DC FieldValueLanguage
dc.contributor.authorCai, YZen_HK
dc.contributor.authorMei Sunen_HK
dc.contributor.authorJie Xingen_HK
dc.contributor.authorLuo, Qen_HK
dc.contributor.authorCorke, Hen_HK
dc.date.accessioned2010-09-06T06:06:58Z-
dc.date.available2010-09-06T06:06:58Z-
dc.date.issued2006en_HK
dc.identifier.citationLife Sciences, 2006, v. 78 n. 25, p. 2872-2888en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68710-
dc.description.abstractTraditional Chinese medicinal plants associated with anticancer contain a wide variety of natural phenolic compounds with various structural features and possessing widely differing antioxidant activity. The structure-radical scavenging activity relationships of a large number of representative phenolic compounds (e.g., flavanols, flavonols, chalcones, flavones, flavanones, isoflavones, tannins, stilbenes, curcuminoids, phenolic acids, coumarins, lignans, and quinones) identified in the traditional Chinese medicinal plants were evaluated using the improved ABTS •+ and DPPH methods. Different categories of tested phenolics showed significant mean differences in radical scavenging activity. Tannins demonstrated the strongest activity, while most quinones, isoflavones, and lignans tested showed the weakest activity. This study confirmed that the number and position of hydroxyl groups and the related glycosylation and other substitutions largely determined radical scavenging activity of the tested phenolic compounds. The differences in radical scavenging activity were attributed to structural differences in hydroxylation, glycosylation and methoxylation. The ortho-dihydroxy groups were the most important structural feature of high activity for all tested phenolic compounds. Other structural features played a modified role in enhancing or reducing the activity. Within each class of phenolic compounds, the structure-activity relationship was elucidated and discussed. This study reveals the structure-activity relationships of a large series of representative natural phenolic compounds more systematically and fully than previous work. Structure-radical scavenging activity relationships of some natural phenolics identified in the medicinal plants were evaluated for the first time. © 2005 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.subjectCoumarinsen_HK
dc.subjectFlavonoidsen_HK
dc.subjectLignansen_HK
dc.subjectPhenolic acidsen_HK
dc.subjectPhenolic compoundsen_HK
dc.subjectQuinonesen_HK
dc.subjectRadical scavenging activityen_HK
dc.subjectStilbenesen_HK
dc.subjectStructure-activity relationshipsen_HK
dc.subjectTanninsen_HK
dc.subjectTraditional Chinese medicinal plantsen_HK
dc.subject.meshDrugs, Chinese Herbal - chemistry - pharmacology-
dc.subject.meshFree Radical Scavengers - chemistry - pharmacology-
dc.subject.meshMedicine, Chinese Traditional-
dc.subject.meshPhenols - chemistry - pharmacology-
dc.subject.meshPlants, Medicinal - chemistry-
dc.titleStructure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plantsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=78&issue=25&spage=2872&epage=2888&date=15&atitle=Structure-radical+scavenging+activity+relationships+of+phenolic+compounds+from+traditional+Chinese+medicinal+plantsen_HK
dc.identifier.emailCai, YZ: yzcai@hkucc.hku.hken_HK
dc.identifier.emailMei Sun: meisun@hkucc.hku.hken_HK
dc.identifier.emailCorke, H: harold@hku.hken_HK
dc.identifier.authorityCai, YZ=rp00661en_HK
dc.identifier.authorityMei Sun=rp00779en_HK
dc.identifier.authorityCorke, H=rp00688en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.lfs.2005.11.004en_HK
dc.identifier.pmid16325868en_HK
dc.identifier.scopuseid_2-s2.0-33646186813en_HK
dc.identifier.hkuros115793en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646186813&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume78en_HK
dc.identifier.issue25en_HK
dc.identifier.spage2872en_HK
dc.identifier.epage2888en_HK
dc.identifier.isiWOS:000237749200002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCai, YZ=8684149300en_HK
dc.identifier.scopusauthoridMei Sun=7403181447en_HK
dc.identifier.scopusauthoridJie Xing=13104878800en_HK
dc.identifier.scopusauthoridLuo, Q=35311306700en_HK
dc.identifier.scopusauthoridCorke, H=7007102942en_HK

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