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Article: Structure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants
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TitleStructure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants
 
AuthorsCai, YZ1
Mei Sun1
Jie Xing3
Luo, Q2
Corke, H1
 
KeywordsCoumarins
Flavonoids
Lignans
Phenolic acids
Phenolic compounds
Quinones
Radical scavenging activity
Stilbenes
Structure-activity relationships
Tannins
Traditional Chinese medicinal plants
 
Issue Date2006
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
 
CitationLife Sciences, 2006, v. 78 n. 25, p. 2872-2888 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.lfs.2005.11.004
 
AbstractTraditional Chinese medicinal plants associated with anticancer contain a wide variety of natural phenolic compounds with various structural features and possessing widely differing antioxidant activity. The structure-radical scavenging activity relationships of a large number of representative phenolic compounds (e.g., flavanols, flavonols, chalcones, flavones, flavanones, isoflavones, tannins, stilbenes, curcuminoids, phenolic acids, coumarins, lignans, and quinones) identified in the traditional Chinese medicinal plants were evaluated using the improved ABTS •+ and DPPH methods. Different categories of tested phenolics showed significant mean differences in radical scavenging activity. Tannins demonstrated the strongest activity, while most quinones, isoflavones, and lignans tested showed the weakest activity. This study confirmed that the number and position of hydroxyl groups and the related glycosylation and other substitutions largely determined radical scavenging activity of the tested phenolic compounds. The differences in radical scavenging activity were attributed to structural differences in hydroxylation, glycosylation and methoxylation. The ortho-dihydroxy groups were the most important structural feature of high activity for all tested phenolic compounds. Other structural features played a modified role in enhancing or reducing the activity. Within each class of phenolic compounds, the structure-activity relationship was elucidated and discussed. This study reveals the structure-activity relationships of a large series of representative natural phenolic compounds more systematically and fully than previous work. Structure-radical scavenging activity relationships of some natural phenolics identified in the medicinal plants were evaluated for the first time. © 2005 Elsevier Inc. All rights reserved.
 
ISSN0024-3205
2012 Impact Factor: 2.555
2012 SCImago Journal Rankings: 0.762
 
DOIhttp://dx.doi.org/10.1016/j.lfs.2005.11.004
 
ISI Accession Number IDWOS:000237749200002
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCai, YZ
 
dc.contributor.authorMei Sun
 
dc.contributor.authorJie Xing
 
dc.contributor.authorLuo, Q
 
dc.contributor.authorCorke, H
 
dc.date.accessioned2010-09-06T06:06:58Z
 
dc.date.available2010-09-06T06:06:58Z
 
dc.date.issued2006
 
dc.description.abstractTraditional Chinese medicinal plants associated with anticancer contain a wide variety of natural phenolic compounds with various structural features and possessing widely differing antioxidant activity. The structure-radical scavenging activity relationships of a large number of representative phenolic compounds (e.g., flavanols, flavonols, chalcones, flavones, flavanones, isoflavones, tannins, stilbenes, curcuminoids, phenolic acids, coumarins, lignans, and quinones) identified in the traditional Chinese medicinal plants were evaluated using the improved ABTS •+ and DPPH methods. Different categories of tested phenolics showed significant mean differences in radical scavenging activity. Tannins demonstrated the strongest activity, while most quinones, isoflavones, and lignans tested showed the weakest activity. This study confirmed that the number and position of hydroxyl groups and the related glycosylation and other substitutions largely determined radical scavenging activity of the tested phenolic compounds. The differences in radical scavenging activity were attributed to structural differences in hydroxylation, glycosylation and methoxylation. The ortho-dihydroxy groups were the most important structural feature of high activity for all tested phenolic compounds. Other structural features played a modified role in enhancing or reducing the activity. Within each class of phenolic compounds, the structure-activity relationship was elucidated and discussed. This study reveals the structure-activity relationships of a large series of representative natural phenolic compounds more systematically and fully than previous work. Structure-radical scavenging activity relationships of some natural phenolics identified in the medicinal plants were evaluated for the first time. © 2005 Elsevier Inc. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationLife Sciences, 2006, v. 78 n. 25, p. 2872-2888 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.lfs.2005.11.004
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.lfs.2005.11.004
 
dc.identifier.epage2888
 
dc.identifier.hkuros115793
 
dc.identifier.isiWOS:000237749200002
 
dc.identifier.issn0024-3205
2012 Impact Factor: 2.555
2012 SCImago Journal Rankings: 0.762
 
dc.identifier.issue25
 
dc.identifier.openurl
 
dc.identifier.pmid16325868
 
dc.identifier.scopuseid_2-s2.0-33646186813
 
dc.identifier.spage2872
 
dc.identifier.urihttp://hdl.handle.net/10722/68710
 
dc.identifier.volume78
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
 
dc.publisher.placeUnited States
 
dc.relation.ispartofLife Sciences
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshDrugs, Chinese Herbal - chemistry - pharmacology
 
dc.subject.meshFree Radical Scavengers - chemistry - pharmacology
 
dc.subject.meshMedicine, Chinese Traditional
 
dc.subject.meshPhenols - chemistry - pharmacology
 
dc.subject.meshPlants, Medicinal - chemistry
 
dc.subjectCoumarins
 
dc.subjectFlavonoids
 
dc.subjectLignans
 
dc.subjectPhenolic acids
 
dc.subjectPhenolic compounds
 
dc.subjectQuinones
 
dc.subjectRadical scavenging activity
 
dc.subjectStilbenes
 
dc.subjectStructure-activity relationships
 
dc.subjectTannins
 
dc.subjectTraditional Chinese medicinal plants
 
dc.titleStructure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Wuhan University
  3. Republic Polytechnic