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Article: Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum
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TitleHypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum
 
AuthorsLuo, Q2
Cai, Y1
Yan, J2
Sun, M1
Corke, H1
 
KeywordsAntioxidant activity
Diabetes
Hyperlipidemia
Hypoglycemic
Hypolipidemic
Lycium barbarum
Polysaccharides
Traditional Chinese medicinal herbs
 
Issue Date2004
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
 
CitationLife Sciences, 2004, v. 76 n. 2, p. 137-149 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.lfs.2004.04.056
 
AbstractThe hypoglycemic and hypolipidemic effects of Lycium barbarum fruit water decoction, crude polysaccharide extracts (crude LBP), and purified polysaccharide fractions (LBP-X) in alloxan-induced diabetic or hyperlipidemic rabbits were investigated through designed sequential trials and by measuring blood glucose and serum lipid parameters. Total antioxidant capacity was also assessed using trolox equivalent antioxidant capacity (TEAC) and oxygen radical absorbance capacity (ORAC) assay. It was found that the three Lycium barbarum fruit extracts/fractions could significantly reduce blood glucose levels and serum total cholesterol (TC) and triglyceride (TG) concentrations and at same time markedly increase high density lipoprotein cholesterol (HDL-c) levels after 10 days treatment in tested rabbits, indicating that there were substantial hypoglycemic and hypolipidemic effects. Hypoglycemic effect of LBP-X was more significant than those of water decoction and crude LBP, but its hypolipidemic effect seemed to be weaker. Total antioxidant capacity assay showed that all three Lycium barbarum extracts/fractions possessed antioxidant activity. However, water and methanolc fruit extracts and crude polysaccharide extracts exhibited stronger antioxidant activity than purified polysaccharide fractions because crude extracts were identified to be rich in antioxidants (e.g., carotenoids, riboflavin, ascorbic acid, thiamine, nicotinic acid). Lycium barbarum polysaccharides (glycocojugates), containing several monosaccharides and 17 amino acids, were major bioactive constituents of hypoglycemic effect. Both polysaccharides and vitamin antioxidants from Lycium barbarum fruits were possible active principles of hypolipidemic effect. © 2004 Elsevier Inc. All rights reserved.
 
ISSN0024-3205
2013 Impact Factor: 2.296
2013 SCImago Journal Rankings: 0.962
 
DOIhttp://dx.doi.org/10.1016/j.lfs.2004.04.056
 
ISI Accession Number IDWOS:000225008900002
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLuo, Q
 
dc.contributor.authorCai, Y
 
dc.contributor.authorYan, J
 
dc.contributor.authorSun, M
 
dc.contributor.authorCorke, H
 
dc.date.accessioned2010-09-06T06:06:32Z
 
dc.date.available2010-09-06T06:06:32Z
 
dc.date.issued2004
 
dc.description.abstractThe hypoglycemic and hypolipidemic effects of Lycium barbarum fruit water decoction, crude polysaccharide extracts (crude LBP), and purified polysaccharide fractions (LBP-X) in alloxan-induced diabetic or hyperlipidemic rabbits were investigated through designed sequential trials and by measuring blood glucose and serum lipid parameters. Total antioxidant capacity was also assessed using trolox equivalent antioxidant capacity (TEAC) and oxygen radical absorbance capacity (ORAC) assay. It was found that the three Lycium barbarum fruit extracts/fractions could significantly reduce blood glucose levels and serum total cholesterol (TC) and triglyceride (TG) concentrations and at same time markedly increase high density lipoprotein cholesterol (HDL-c) levels after 10 days treatment in tested rabbits, indicating that there were substantial hypoglycemic and hypolipidemic effects. Hypoglycemic effect of LBP-X was more significant than those of water decoction and crude LBP, but its hypolipidemic effect seemed to be weaker. Total antioxidant capacity assay showed that all three Lycium barbarum extracts/fractions possessed antioxidant activity. However, water and methanolc fruit extracts and crude polysaccharide extracts exhibited stronger antioxidant activity than purified polysaccharide fractions because crude extracts were identified to be rich in antioxidants (e.g., carotenoids, riboflavin, ascorbic acid, thiamine, nicotinic acid). Lycium barbarum polysaccharides (glycocojugates), containing several monosaccharides and 17 amino acids, were major bioactive constituents of hypoglycemic effect. Both polysaccharides and vitamin antioxidants from Lycium barbarum fruits were possible active principles of hypolipidemic effect. © 2004 Elsevier Inc. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationLife Sciences, 2004, v. 76 n. 2, p. 137-149 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.lfs.2004.04.056
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.lfs.2004.04.056
 
dc.identifier.epage149
 
dc.identifier.hkuros103396
 
dc.identifier.isiWOS:000225008900002
 
dc.identifier.issn0024-3205
2013 Impact Factor: 2.296
2013 SCImago Journal Rankings: 0.962
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid15519360
 
dc.identifier.scopuseid_2-s2.0-7044271148
 
dc.identifier.spage137
 
dc.identifier.urihttp://hdl.handle.net/10722/68660
 
dc.identifier.volume76
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
 
dc.publisher.placeUnited States
 
dc.relation.ispartofLife Sciences
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshDiabetes Mellitus, Experimental - blood - drug therapy
 
dc.subject.meshDrugs, Chinese Herbal - isolation and purification - therapeutic use
 
dc.subject.meshHypoglycemic Agents - isolation and purification - therapeutic use
 
dc.subject.meshHypolipidemic Agents - isolation and purification - therapeutic use
 
dc.subject.meshLycium - chemistry
 
dc.subjectAntioxidant activity
 
dc.subjectDiabetes
 
dc.subjectHyperlipidemia
 
dc.subjectHypoglycemic
 
dc.subjectHypolipidemic
 
dc.subjectLycium barbarum
 
dc.subjectPolysaccharides
 
dc.subjectTraditional Chinese medicinal herbs
 
dc.titleHypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Wuhan University