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Article: Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum

TitleHypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum
Authors
KeywordsAntioxidant activity
Diabetes
Hyperlipidemia
Hypoglycemic
Hypolipidemic
Lycium barbarum
Polysaccharides
Traditional Chinese medicinal herbs
Issue Date2004
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2004, v. 76 n. 2, p. 137-149 How to Cite?
AbstractThe hypoglycemic and hypolipidemic effects of Lycium barbarum fruit water decoction, crude polysaccharide extracts (crude LBP), and purified polysaccharide fractions (LBP-X) in alloxan-induced diabetic or hyperlipidemic rabbits were investigated through designed sequential trials and by measuring blood glucose and serum lipid parameters. Total antioxidant capacity was also assessed using trolox equivalent antioxidant capacity (TEAC) and oxygen radical absorbance capacity (ORAC) assay. It was found that the three Lycium barbarum fruit extracts/fractions could significantly reduce blood glucose levels and serum total cholesterol (TC) and triglyceride (TG) concentrations and at same time markedly increase high density lipoprotein cholesterol (HDL-c) levels after 10 days treatment in tested rabbits, indicating that there were substantial hypoglycemic and hypolipidemic effects. Hypoglycemic effect of LBP-X was more significant than those of water decoction and crude LBP, but its hypolipidemic effect seemed to be weaker. Total antioxidant capacity assay showed that all three Lycium barbarum extracts/fractions possessed antioxidant activity. However, water and methanolc fruit extracts and crude polysaccharide extracts exhibited stronger antioxidant activity than purified polysaccharide fractions because crude extracts were identified to be rich in antioxidants (e.g., carotenoids, riboflavin, ascorbic acid, thiamine, nicotinic acid). Lycium barbarum polysaccharides (glycocojugates), containing several monosaccharides and 17 amino acids, were major bioactive constituents of hypoglycemic effect. Both polysaccharides and vitamin antioxidants from Lycium barbarum fruits were possible active principles of hypolipidemic effect. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68660
ISSN
2014 Impact Factor: 2.702
2014 SCImago Journal Rankings: 0.921
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLuo, Qen_HK
dc.contributor.authorCai, Yen_HK
dc.contributor.authorYan, Jen_HK
dc.contributor.authorSun, Men_HK
dc.contributor.authorCorke, Hen_HK
dc.date.accessioned2010-09-06T06:06:32Z-
dc.date.available2010-09-06T06:06:32Z-
dc.date.issued2004en_HK
dc.identifier.citationLife Sciences, 2004, v. 76 n. 2, p. 137-149en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68660-
dc.description.abstractThe hypoglycemic and hypolipidemic effects of Lycium barbarum fruit water decoction, crude polysaccharide extracts (crude LBP), and purified polysaccharide fractions (LBP-X) in alloxan-induced diabetic or hyperlipidemic rabbits were investigated through designed sequential trials and by measuring blood glucose and serum lipid parameters. Total antioxidant capacity was also assessed using trolox equivalent antioxidant capacity (TEAC) and oxygen radical absorbance capacity (ORAC) assay. It was found that the three Lycium barbarum fruit extracts/fractions could significantly reduce blood glucose levels and serum total cholesterol (TC) and triglyceride (TG) concentrations and at same time markedly increase high density lipoprotein cholesterol (HDL-c) levels after 10 days treatment in tested rabbits, indicating that there were substantial hypoglycemic and hypolipidemic effects. Hypoglycemic effect of LBP-X was more significant than those of water decoction and crude LBP, but its hypolipidemic effect seemed to be weaker. Total antioxidant capacity assay showed that all three Lycium barbarum extracts/fractions possessed antioxidant activity. However, water and methanolc fruit extracts and crude polysaccharide extracts exhibited stronger antioxidant activity than purified polysaccharide fractions because crude extracts were identified to be rich in antioxidants (e.g., carotenoids, riboflavin, ascorbic acid, thiamine, nicotinic acid). Lycium barbarum polysaccharides (glycocojugates), containing several monosaccharides and 17 amino acids, were major bioactive constituents of hypoglycemic effect. Both polysaccharides and vitamin antioxidants from Lycium barbarum fruits were possible active principles of hypolipidemic effect. © 2004 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.subjectAntioxidant activityen_HK
dc.subjectDiabetesen_HK
dc.subjectHyperlipidemiaen_HK
dc.subjectHypoglycemicen_HK
dc.subjectHypolipidemicen_HK
dc.subjectLycium barbarumen_HK
dc.subjectPolysaccharidesen_HK
dc.subjectTraditional Chinese medicinal herbsen_HK
dc.subject.meshDiabetes Mellitus, Experimental - blood - drug therapy-
dc.subject.meshDrugs, Chinese Herbal - isolation and purification - therapeutic use-
dc.subject.meshHypoglycemic Agents - isolation and purification - therapeutic use-
dc.subject.meshHypolipidemic Agents - isolation and purification - therapeutic use-
dc.subject.meshLycium - chemistry-
dc.titleHypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarumen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=76&issue=2&spage=137&epage=149&date=26&atitle=Hypoglycemic+and+hypolipidemic+effects+and+antioxidant+activity+of+fruit+extracts+from+Lycium+barbarumen_HK
dc.identifier.emailCai, Y: yzcai@hkucc.hku.hken_HK
dc.identifier.emailSun, M: meisun@hkucc.hku.hken_HK
dc.identifier.emailCorke, H: harold@hku.hken_HK
dc.identifier.authorityCai, Y=rp00661en_HK
dc.identifier.authoritySun, M=rp00779en_HK
dc.identifier.authorityCorke, H=rp00688en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.lfs.2004.04.056en_HK
dc.identifier.pmid15519360-
dc.identifier.scopuseid_2-s2.0-7044271148en_HK
dc.identifier.hkuros103396en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-7044271148&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume76en_HK
dc.identifier.issue2en_HK
dc.identifier.spage137en_HK
dc.identifier.epage149en_HK
dc.identifier.isiWOS:000225008900002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLuo, Q=35311306700en_HK
dc.identifier.scopusauthoridCai, Y=8684149300en_HK
dc.identifier.scopusauthoridYan, J=7403729064en_HK
dc.identifier.scopusauthoridSun, M=7403181447en_HK
dc.identifier.scopusauthoridCorke, H=7007102942en_HK

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