Article: Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum

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TitleHypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum
AuthorsLuo, Q2
Cai, Y1
Yan, J2
Sun, M1
Corke, H1
KeywordsAntioxidant activity
Diabetes
Hyperlipidemia
Hypoglycemic
Hypolipidemic
Lycium barbarum
Polysaccharides
Traditional Chinese medicinal herbs
Issue Date2004
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
CitationLife Sciences, 2004, v. 76 n. 2, p. 137-149 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.lfs.2004.04.056
AbstractThe hypoglycemic and hypolipidemic effects of Lycium barbarum fruit water decoction, crude polysaccharide extracts (crude LBP), and purified polysaccharide fractions (LBP-X) in alloxan-induced diabetic or hyperlipidemic rabbits were investigated through designed sequential trials and by measuring blood glucose and serum lipid parameters. Total antioxidant capacity was also assessed using trolox equivalent antioxidant capacity (TEAC) and oxygen radical absorbance capacity (ORAC) assay. It was found that the three Lycium barbarum fruit extracts/fractions could significantly reduce blood glucose levels and serum total cholesterol (TC) and triglyceride (TG) concentrations and at same time markedly increase high density lipoprotein cholesterol (HDL-c) levels after 10 days treatment in tested rabbits, indicating that there were substantial hypoglycemic and hypolipidemic effects. Hypoglycemic effect of LBP-X was more significant than those of water decoction and crude LBP, but its hypolipidemic effect seemed to be weaker. Total antioxidant capacity assay showed that all three Lycium barbarum extracts/fractions possessed antioxidant activity. However, water and methanolc fruit extracts and crude polysaccharide extracts exhibited stronger antioxidant activity than purified polysaccharide fractions because crude extracts were identified to be rich in antioxidants (e.g., carotenoids, riboflavin, ascorbic acid, thiamine, nicotinic acid). Lycium barbarum polysaccharides (glycocojugates), containing several monosaccharides and 17 amino acids, were major bioactive constituents of hypoglycemic effect. Both polysaccharides and vitamin antioxidants from Lycium barbarum fruits were possible active principles of hypolipidemic effect. © 2004 Elsevier Inc. All rights reserved.
ISSN0024-3205
2011 Impact Factor: 2.527
2011 SCImago Journal Rankings: 0.189
DOIhttp://dx.doi.org/10.1016/j.lfs.2004.04.056
ISI Accession Number IDWOS:000225008900002
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLuo, Q
dc.contributor.authorCai, Y
dc.contributor.authorYan, J
dc.contributor.authorSun, M
dc.contributor.authorCorke, H
dc.date.accessioned2010-09-06T06:06:32Z
dc.date.available2010-09-06T06:06:32Z
dc.date.issued2004
dc.description.abstractThe hypoglycemic and hypolipidemic effects of Lycium barbarum fruit water decoction, crude polysaccharide extracts (crude LBP), and purified polysaccharide fractions (LBP-X) in alloxan-induced diabetic or hyperlipidemic rabbits were investigated through designed sequential trials and by measuring blood glucose and serum lipid parameters. Total antioxidant capacity was also assessed using trolox equivalent antioxidant capacity (TEAC) and oxygen radical absorbance capacity (ORAC) assay. It was found that the three Lycium barbarum fruit extracts/fractions could significantly reduce blood glucose levels and serum total cholesterol (TC) and triglyceride (TG) concentrations and at same time markedly increase high density lipoprotein cholesterol (HDL-c) levels after 10 days treatment in tested rabbits, indicating that there were substantial hypoglycemic and hypolipidemic effects. Hypoglycemic effect of LBP-X was more significant than those of water decoction and crude LBP, but its hypolipidemic effect seemed to be weaker. Total antioxidant capacity assay showed that all three Lycium barbarum extracts/fractions possessed antioxidant activity. However, water and methanolc fruit extracts and crude polysaccharide extracts exhibited stronger antioxidant activity than purified polysaccharide fractions because crude extracts were identified to be rich in antioxidants (e.g., carotenoids, riboflavin, ascorbic acid, thiamine, nicotinic acid). Lycium barbarum polysaccharides (glycocojugates), containing several monosaccharides and 17 amino acids, were major bioactive constituents of hypoglycemic effect. Both polysaccharides and vitamin antioxidants from Lycium barbarum fruits were possible active principles of hypolipidemic effect. © 2004 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationLife Sciences, 2004, v. 76 n. 2, p. 137-149 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.lfs.2004.04.056
dc.identifier.doihttp://dx.doi.org/10.1016/j.lfs.2004.04.056
dc.identifier.epage149
dc.identifier.hkuros103396
dc.identifier.isiWOS:000225008900002
dc.identifier.issn0024-3205
2011 Impact Factor: 2.527
2011 SCImago Journal Rankings: 0.189
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmid15519360
dc.identifier.scopuseid_2-s2.0-7044271148
dc.identifier.spage137
dc.identifier.urihttp://hdl.handle.net/10722/68660
dc.identifier.volume76
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
dc.publisher.placeUnited States
dc.relation.ispartofLife Sciences
dc.relation.referencesReferences in Scopus
dc.subject.meshDiabetes Mellitus, Experimental - blood - drug therapy
dc.subject.meshDrugs, Chinese Herbal - isolation and purification - therapeutic use
dc.subject.meshHypoglycemic Agents - isolation and purification - therapeutic use
dc.subject.meshHypolipidemic Agents - isolation and purification - therapeutic use
dc.subject.meshLycium - chemistry
dc.subjectAntioxidant activity
dc.subjectDiabetes
dc.subjectHyperlipidemia
dc.subjectHypoglycemic
dc.subjectHypolipidemic
dc.subjectLycium barbarum
dc.subjectPolysaccharides
dc.subjectTraditional Chinese medicinal herbs
dc.titleHypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Wuhan University