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Article: Application of high-speed counter-current chromatography to the preparative separation and purification of baicalin from the Chinese medicinal plant Scutellaria baicalensis

TitleApplication of high-speed counter-current chromatography to the preparative separation and purification of baicalin from the Chinese medicinal plant Scutellaria baicalensis
Authors
KeywordsBaicalin
Counter-current chromatography
Flavones
Pharmaceutical analysis
Plant materials
Preparative chromatography
Scutellaria baicalensis
Issue Date2003
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/chroma
Citation
Journal Of Chromatography A, 2003, v. 1017 n. 1-2, p. 117-123 How to Cite?
AbstractBaicalin was separated and purified for the first time from the traditional Chinese medicinal plant Scutellaria baicalensis Georgi by high-speed counter-current chromatography. Crude baicalin was obtained by extraction with methanol-water (70:30, v/v) from S. baicalensis Georgi. The separation was performed in two steps with a two-phase solvent system composed of n-butanol-water (1:1, v/v), in which the lower phase was used as the mobile phase at a flow-rate of 1.0mlmin-1 in the head-to-tail elution mode. A total of 37.0mg of baicalin at 96.5% purity was yielded from 200mg of the crude baicalin (containing 21.6% baicalin) with 86.0% recovery as determined by HPLC analysis. © 2003 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68630
ISSN
2015 Impact Factor: 3.926
2015 SCImago Journal Rankings: 1.774
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLu, HTen_HK
dc.contributor.authorJiang, Yen_HK
dc.contributor.authorChen, Fen_HK
dc.date.accessioned2010-09-06T06:06:17Z-
dc.date.available2010-09-06T06:06:17Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Chromatography A, 2003, v. 1017 n. 1-2, p. 117-123en_HK
dc.identifier.issn0021-9673en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68630-
dc.description.abstractBaicalin was separated and purified for the first time from the traditional Chinese medicinal plant Scutellaria baicalensis Georgi by high-speed counter-current chromatography. Crude baicalin was obtained by extraction with methanol-water (70:30, v/v) from S. baicalensis Georgi. The separation was performed in two steps with a two-phase solvent system composed of n-butanol-water (1:1, v/v), in which the lower phase was used as the mobile phase at a flow-rate of 1.0mlmin-1 in the head-to-tail elution mode. A total of 37.0mg of baicalin at 96.5% purity was yielded from 200mg of the crude baicalin (containing 21.6% baicalin) with 86.0% recovery as determined by HPLC analysis. © 2003 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/chromaen_HK
dc.relation.ispartofJournal of Chromatography Aen_HK
dc.rightsJournal of Chromatography A. Copyright © Elsevier BV.en_HK
dc.subjectBaicalinen_HK
dc.subjectCounter-current chromatographyen_HK
dc.subjectFlavonesen_HK
dc.subjectPharmaceutical analysisen_HK
dc.subjectPlant materialsen_HK
dc.subjectPreparative chromatographyen_HK
dc.subjectScutellaria baicalensisen_HK
dc.titleApplication of high-speed counter-current chromatography to the preparative separation and purification of baicalin from the Chinese medicinal plant Scutellaria baicalensisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9673&volume=1017&spage=117&epage=123&date=2003&atitle=Application+of+high-speed+counter-current+chromatography+to+the+preparative+separation+and+purification+of+baicalin+from+the+Chinese+medicinal+plant+Scutellaria+baicalensisen_HK
dc.identifier.emailChen, F: sfchen@hku.hken_HK
dc.identifier.authorityChen, F=rp00672en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.chroma.2003.08.012en_HK
dc.identifier.pmid14584696-
dc.identifier.scopuseid_2-s2.0-0141528505en_HK
dc.identifier.hkuros90949en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141528505&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1017en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage117en_HK
dc.identifier.epage123en_HK
dc.identifier.isiWOS:000185856600011-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLu, HT=7404843255en_HK
dc.identifier.scopusauthoridJiang, Y=24605346600en_HK
dc.identifier.scopusauthoridChen, F=7404907980en_HK

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