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Article: Heterotrophic production of eicosapentaenoic acid by microalgae

TitleHeterotrophic production of eicosapentaenoic acid by microalgae
Authors
KeywordsDiatom
Eicosapentaenoic acid
Microalgae
Polyunsaturated fatty acids
Issue Date2003
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biotechadv
Citation
Biotechnology Advances, 2003, v. 21 n. 4, p. 273-294 How to Cite?
AbstractEicosapentaenoic acid (EPA) is an ω-3 polyunsaturated fatty acid that plays an important role in the regulation of biological functions and prevention and treatment of a number of human diseases such as heart and inflammatory diseases. As fish oil fails to meet the increasing demand for purified EPA, alternative sources are being sought. Microalgae contain large quantities of high-quality EPA and they are considered a potential source of this important fatty acid. Some microalgae can be grown heterotrophically on cheap organic substrate without light. This mode of cultivation can be well controlled and provides the possibility to maximize EPA production on a large scale. Numerous strategies have been investigated for commercial production of EPA by microalgae. These include screening of high EPA-yielding microalgal strains, improvement of strains by genetic manipulation, optimization of culture conditions, and development of efficient cultivation systems. This paper reviews recent advances in heterotrophic production of EPA by microalgae with an emphasis on the use of diatoms as producing organisms. © 2003 Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68519
ISSN
2015 Impact Factor: 9.848
2015 SCImago Journal Rankings: 2.921
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWen, ZYen_HK
dc.contributor.authorChen, Fen_HK
dc.date.accessioned2010-09-06T06:05:19Z-
dc.date.available2010-09-06T06:05:19Z-
dc.date.issued2003en_HK
dc.identifier.citationBiotechnology Advances, 2003, v. 21 n. 4, p. 273-294en_HK
dc.identifier.issn0734-9750en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68519-
dc.description.abstractEicosapentaenoic acid (EPA) is an ω-3 polyunsaturated fatty acid that plays an important role in the regulation of biological functions and prevention and treatment of a number of human diseases such as heart and inflammatory diseases. As fish oil fails to meet the increasing demand for purified EPA, alternative sources are being sought. Microalgae contain large quantities of high-quality EPA and they are considered a potential source of this important fatty acid. Some microalgae can be grown heterotrophically on cheap organic substrate without light. This mode of cultivation can be well controlled and provides the possibility to maximize EPA production on a large scale. Numerous strategies have been investigated for commercial production of EPA by microalgae. These include screening of high EPA-yielding microalgal strains, improvement of strains by genetic manipulation, optimization of culture conditions, and development of efficient cultivation systems. This paper reviews recent advances in heterotrophic production of EPA by microalgae with an emphasis on the use of diatoms as producing organisms. © 2003 Elsevier Science Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biotechadven_HK
dc.relation.ispartofBiotechnology Advancesen_HK
dc.rightsBiotechnology Advances. Copyright © Elsevier Inc.en_HK
dc.subjectDiatomen_HK
dc.subjectEicosapentaenoic aciden_HK
dc.subjectMicroalgaeen_HK
dc.subjectPolyunsaturated fatty acidsen_HK
dc.titleHeterotrophic production of eicosapentaenoic acid by microalgaeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0734-9750&volume=21&issue=4&spage=273&epage=294&date=2003&atitle=Heterotrophic+production+of+eicosapentaenoic+acid+by+microalgaeen_HK
dc.identifier.emailChen, F: sfchen@hku.hken_HK
dc.identifier.authorityChen, F=rp00672en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0734-9750(03)00051-Xen_HK
dc.identifier.pmid14499126-
dc.identifier.scopuseid_2-s2.0-0037492427en_HK
dc.identifier.hkuros90970en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037492427&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue4en_HK
dc.identifier.spage273en_HK
dc.identifier.epage294en_HK
dc.identifier.isiWOS:000184693800001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWen, ZY=14012373200en_HK
dc.identifier.scopusauthoridChen, F=7404907980en_HK

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