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Article: Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H 2O 2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats

TitleLycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H 2O 2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats
Authors
KeywordsDNA damage
Fertility
Hemicastrated rats
Infertility
Lycium barbarum
Mice
Polysaccharides
Rats
Reproductive function
Sexual behavior
Sexual hormones
Testis
Traditional Chinese medicine
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2006, v. 79 n. 7, p. 613-621 How to Cite?
AbstractLycium barbarum, a famous Chinese medicinal herb, has a long history of use as a traditional remedy for male infertility. Polysaccharides are the most important functional constituent in L. barbarum fruits. We systematically investigated the effect of L. barbarum polysaccharides (LBP) on rat testis damage induced by a physical factor (43  °C heat exposure), on DNA damage of mouse testicular cells induced by a chemical factor (H 2O 2), and on sexual behavior and reproductive function of hemicastrated male rats. The results showed that LBP provided a protective effect against the testicular tissue damage induced by heat exposure. When compared with negative control, a suitable concentration of LBP significantly increased testis and epididymis weights, improved superoxide dismutase (SOD) activity, and raised sexual hormone levels in the damaged rat testes. LBP had a dose-dependent protective effect against DNA oxidative damage of mouse testicular cells induced by H 2O 2. LBP improved the copulatory performance and reproductive function of hemicastrated male rats, such as shortened penis erection latency and mount latency, regulated secretion of sexual hormones and increased hormone levels, raised accessory sexual organ weights, and improved sperm quantity and quality. The present findings support the folk reputation of L. barbarum fruits as an aphrodisiac and fertility-facilitating agent, and provide scientific evidence for a basis for the extensive use of L. barbarum fruits as a traditional remedy for male infertility in China. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68508
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLuo, Qen_HK
dc.contributor.authorLi, Zen_HK
dc.contributor.authorHuang, Xen_HK
dc.contributor.authorYan, Jen_HK
dc.contributor.authorZhang, Sen_HK
dc.contributor.authorCai, YZen_HK
dc.date.accessioned2010-09-06T06:05:13Z-
dc.date.available2010-09-06T06:05:13Z-
dc.date.issued2006en_HK
dc.identifier.citationLife Sciences, 2006, v. 79 n. 7, p. 613-621en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68508-
dc.description.abstractLycium barbarum, a famous Chinese medicinal herb, has a long history of use as a traditional remedy for male infertility. Polysaccharides are the most important functional constituent in L. barbarum fruits. We systematically investigated the effect of L. barbarum polysaccharides (LBP) on rat testis damage induced by a physical factor (43  °C heat exposure), on DNA damage of mouse testicular cells induced by a chemical factor (H 2O 2), and on sexual behavior and reproductive function of hemicastrated male rats. The results showed that LBP provided a protective effect against the testicular tissue damage induced by heat exposure. When compared with negative control, a suitable concentration of LBP significantly increased testis and epididymis weights, improved superoxide dismutase (SOD) activity, and raised sexual hormone levels in the damaged rat testes. LBP had a dose-dependent protective effect against DNA oxidative damage of mouse testicular cells induced by H 2O 2. LBP improved the copulatory performance and reproductive function of hemicastrated male rats, such as shortened penis erection latency and mount latency, regulated secretion of sexual hormones and increased hormone levels, raised accessory sexual organ weights, and improved sperm quantity and quality. The present findings support the folk reputation of L. barbarum fruits as an aphrodisiac and fertility-facilitating agent, and provide scientific evidence for a basis for the extensive use of L. barbarum fruits as a traditional remedy for male infertility in China. © 2006 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.subjectDNA damageen_HK
dc.subjectFertilityen_HK
dc.subjectHemicastrated ratsen_HK
dc.subjectInfertilityen_HK
dc.subjectLycium barbarumen_HK
dc.subjectMiceen_HK
dc.subjectPolysaccharidesen_HK
dc.subjectRatsen_HK
dc.subjectReproductive functionen_HK
dc.subjectSexual behavioren_HK
dc.subjectSexual hormonesen_HK
dc.subjectTestisen_HK
dc.subjectTraditional Chinese medicineen_HK
dc.subject.meshAntioxidants-
dc.subject.meshDNA Damage - drug effects-
dc.subject.meshHot Temperature - adverse effects-
dc.subject.meshHydrogen Peroxide - antagonists and inhibitors - toxicity-
dc.subject.meshLycium - chemistry-
dc.titleLycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H 2O 2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=79&issue=7&spage=613&epage=621&date=2006&atitle=Lycium+barbarum+polysaccharides:+Protective+effects+against+heat-induced+damage+of+rat+testes+and+H2O2-induced+DNA+damage+in+mouse+testicular+cells+and+beneficial+effect+on+sexual+behavior+and+reproductive+function+of+hemicastrated+ratsen_HK
dc.identifier.emailCai, YZ: yzcai@hkucc.hku.hken_HK
dc.identifier.authorityCai, YZ=rp00661en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.lfs.2006.02.012en_HK
dc.identifier.pmid16563441-
dc.identifier.scopuseid_2-s2.0-33745263023en_HK
dc.identifier.hkuros129913en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745263023&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume79en_HK
dc.identifier.issue7en_HK
dc.identifier.spage613en_HK
dc.identifier.epage621en_HK
dc.identifier.isiWOS:000238873500001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLuo, Q=35311306700en_HK
dc.identifier.scopusauthoridLi, Z=14019808400en_HK
dc.identifier.scopusauthoridHuang, X=55500194300en_HK
dc.identifier.scopusauthoridYan, J=7403729064en_HK
dc.identifier.scopusauthoridZhang, S=7409377845en_HK
dc.identifier.scopusauthoridCai, YZ=8684149300en_HK

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