Article: Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H 2O 2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats

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TitleLycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H 2O 2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats
AuthorsLuo, Q2
Li, Z2
Huang, X2
Yan, J2
Zhang, S3
Cai, YZ1 2
KeywordsDNA damage
Fertility
Hemicastrated rats
Infertility
Lycium barbarum
Mice
Polysaccharides
Rats
Reproductive function
Sexual behavior
Sexual hormones
Testis
Traditional Chinese medicine
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
CitationLife Sciences, 2006, v. 79 n. 7, p. 613-621 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.lfs.2006.02.012
AbstractLycium barbarum, a famous Chinese medicinal herb, has a long history of use as a traditional remedy for male infertility. Polysaccharides are the most important functional constituent in L. barbarum fruits. We systematically investigated the effect of L. barbarum polysaccharides (LBP) on rat testis damage induced by a physical factor (43  °C heat exposure), on DNA damage of mouse testicular cells induced by a chemical factor (H 2O 2), and on sexual behavior and reproductive function of hemicastrated male rats. The results showed that LBP provided a protective effect against the testicular tissue damage induced by heat exposure. When compared with negative control, a suitable concentration of LBP significantly increased testis and epididymis weights, improved superoxide dismutase (SOD) activity, and raised sexual hormone levels in the damaged rat testes. LBP had a dose-dependent protective effect against DNA oxidative damage of mouse testicular cells induced by H 2O 2. LBP improved the copulatory performance and reproductive function of hemicastrated male rats, such as shortened penis erection latency and mount latency, regulated secretion of sexual hormones and increased hormone levels, raised accessory sexual organ weights, and improved sperm quantity and quality. The present findings support the folk reputation of L. barbarum fruits as an aphrodisiac and fertility-facilitating agent, and provide scientific evidence for a basis for the extensive use of L. barbarum fruits as a traditional remedy for male infertility in China. © 2006 Elsevier Inc. All rights reserved.
ISSN0024-3205
2011 Impact Factor: 2.527
2011 SCImago Journal Rankings: 0.189
DOIhttp://dx.doi.org/10.1016/j.lfs.2006.02.012
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLuo, Q
dc.contributor.authorLi, Z
dc.contributor.authorHuang, X
dc.contributor.authorYan, J
dc.contributor.authorZhang, S
dc.contributor.authorCai, YZ
dc.date.accessioned2010-09-06T06:05:13Z
dc.date.available2010-09-06T06:05:13Z
dc.date.issued2006
dc.description.abstractLycium barbarum, a famous Chinese medicinal herb, has a long history of use as a traditional remedy for male infertility. Polysaccharides are the most important functional constituent in L. barbarum fruits. We systematically investigated the effect of L. barbarum polysaccharides (LBP) on rat testis damage induced by a physical factor (43  °C heat exposure), on DNA damage of mouse testicular cells induced by a chemical factor (H 2O 2), and on sexual behavior and reproductive function of hemicastrated male rats. The results showed that LBP provided a protective effect against the testicular tissue damage induced by heat exposure. When compared with negative control, a suitable concentration of LBP significantly increased testis and epididymis weights, improved superoxide dismutase (SOD) activity, and raised sexual hormone levels in the damaged rat testes. LBP had a dose-dependent protective effect against DNA oxidative damage of mouse testicular cells induced by H 2O 2. LBP improved the copulatory performance and reproductive function of hemicastrated male rats, such as shortened penis erection latency and mount latency, regulated secretion of sexual hormones and increased hormone levels, raised accessory sexual organ weights, and improved sperm quantity and quality. The present findings support the folk reputation of L. barbarum fruits as an aphrodisiac and fertility-facilitating agent, and provide scientific evidence for a basis for the extensive use of L. barbarum fruits as a traditional remedy for male infertility in China. © 2006 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationLife Sciences, 2006, v. 79 n. 7, p. 613-621 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.lfs.2006.02.012
dc.identifier.doihttp://dx.doi.org/10.1016/j.lfs.2006.02.012
dc.identifier.epage621
dc.identifier.hkuros129913
dc.identifier.isiWOS:000238873500001
dc.identifier.issn0024-3205
2011 Impact Factor: 2.527
2011 SCImago Journal Rankings: 0.189
dc.identifier.issue7
dc.identifier.openurl
dc.identifier.pmid16563441
dc.identifier.scopuseid_2-s2.0-33745263023
dc.identifier.spage613
dc.identifier.urihttp://hdl.handle.net/10722/68508
dc.identifier.volume79
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
dc.publisher.placeUnited States
dc.relation.ispartofLife Sciences
dc.relation.referencesReferences in Scopus
dc.subject.meshAntioxidants
dc.subject.meshDNA Damage - drug effects
dc.subject.meshHot Temperature - adverse effects
dc.subject.meshHydrogen Peroxide - antagonists and inhibitors - toxicity
dc.subject.meshLycium - chemistry
dc.subjectDNA damage
dc.subjectFertility
dc.subjectHemicastrated rats
dc.subjectInfertility
dc.subjectLycium barbarum
dc.subjectMice
dc.subjectPolysaccharides
dc.subjectRats
dc.subjectReproductive function
dc.subjectSexual behavior
dc.subjectSexual hormones
dc.subjectTestis
dc.subjectTraditional Chinese medicine
dc.titleLycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H 2O 2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Wuhan University
  3. Huazhong Agricultural University