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Article: Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H 2O 2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats
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TitleLycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H 2O 2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats
 
AuthorsLuo, Q2
Li, Z2
Huang, X2
Yan, J2
Zhang, S3
Cai, YZ2 1
 
KeywordsDNA damage
Fertility
Hemicastrated rats
Infertility
Lycium barbarum
Mice
Polysaccharides
Rats
Reproductive function
Sexual behavior
Sexual hormones
Testis
Traditional Chinese medicine
 
Issue Date2006
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
 
CitationLife Sciences, 2006, v. 79 n. 7, p. 613-621 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.lfs.2006.02.012
 
AbstractLycium barbarum, a famous Chinese medicinal herb, has a long history of use as a traditional remedy for male infertility. Polysaccharides are the most important functional constituent in L. barbarum fruits. We systematically investigated the effect of L. barbarum polysaccharides (LBP) on rat testis damage induced by a physical factor (43  °C heat exposure), on DNA damage of mouse testicular cells induced by a chemical factor (H 2O 2), and on sexual behavior and reproductive function of hemicastrated male rats. The results showed that LBP provided a protective effect against the testicular tissue damage induced by heat exposure. When compared with negative control, a suitable concentration of LBP significantly increased testis and epididymis weights, improved superoxide dismutase (SOD) activity, and raised sexual hormone levels in the damaged rat testes. LBP had a dose-dependent protective effect against DNA oxidative damage of mouse testicular cells induced by H 2O 2. LBP improved the copulatory performance and reproductive function of hemicastrated male rats, such as shortened penis erection latency and mount latency, regulated secretion of sexual hormones and increased hormone levels, raised accessory sexual organ weights, and improved sperm quantity and quality. The present findings support the folk reputation of L. barbarum fruits as an aphrodisiac and fertility-facilitating agent, and provide scientific evidence for a basis for the extensive use of L. barbarum fruits as a traditional remedy for male infertility in China. © 2006 Elsevier Inc. All rights reserved.
 
ISSN0024-3205
2013 Impact Factor: 2.296
2013 SCImago Journal Rankings: 0.962
 
DOIhttp://dx.doi.org/10.1016/j.lfs.2006.02.012
 
ISI Accession Number IDWOS:000238873500001
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLuo, Q
 
dc.contributor.authorLi, Z
 
dc.contributor.authorHuang, X
 
dc.contributor.authorYan, J
 
dc.contributor.authorZhang, S
 
dc.contributor.authorCai, YZ
 
dc.date.accessioned2010-09-06T06:05:13Z
 
dc.date.available2010-09-06T06:05:13Z
 
dc.date.issued2006
 
dc.description.abstractLycium barbarum, a famous Chinese medicinal herb, has a long history of use as a traditional remedy for male infertility. Polysaccharides are the most important functional constituent in L. barbarum fruits. We systematically investigated the effect of L. barbarum polysaccharides (LBP) on rat testis damage induced by a physical factor (43  °C heat exposure), on DNA damage of mouse testicular cells induced by a chemical factor (H 2O 2), and on sexual behavior and reproductive function of hemicastrated male rats. The results showed that LBP provided a protective effect against the testicular tissue damage induced by heat exposure. When compared with negative control, a suitable concentration of LBP significantly increased testis and epididymis weights, improved superoxide dismutase (SOD) activity, and raised sexual hormone levels in the damaged rat testes. LBP had a dose-dependent protective effect against DNA oxidative damage of mouse testicular cells induced by H 2O 2. LBP improved the copulatory performance and reproductive function of hemicastrated male rats, such as shortened penis erection latency and mount latency, regulated secretion of sexual hormones and increased hormone levels, raised accessory sexual organ weights, and improved sperm quantity and quality. The present findings support the folk reputation of L. barbarum fruits as an aphrodisiac and fertility-facilitating agent, and provide scientific evidence for a basis for the extensive use of L. barbarum fruits as a traditional remedy for male infertility in China. © 2006 Elsevier Inc. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationLife Sciences, 2006, v. 79 n. 7, p. 613-621 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.lfs.2006.02.012
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.lfs.2006.02.012
 
dc.identifier.epage621
 
dc.identifier.hkuros129913
 
dc.identifier.isiWOS:000238873500001
 
dc.identifier.issn0024-3205
2013 Impact Factor: 2.296
2013 SCImago Journal Rankings: 0.962
 
dc.identifier.issue7
 
dc.identifier.openurl
 
dc.identifier.pmid16563441
 
dc.identifier.scopuseid_2-s2.0-33745263023
 
dc.identifier.spage613
 
dc.identifier.urihttp://hdl.handle.net/10722/68508
 
dc.identifier.volume79
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
 
dc.publisher.placeUnited States
 
dc.relation.ispartofLife Sciences
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAntioxidants
 
dc.subject.meshDNA Damage - drug effects
 
dc.subject.meshHot Temperature - adverse effects
 
dc.subject.meshHydrogen Peroxide - antagonists and inhibitors - toxicity
 
dc.subject.meshLycium - chemistry
 
dc.subjectDNA damage
 
dc.subjectFertility
 
dc.subjectHemicastrated rats
 
dc.subjectInfertility
 
dc.subjectLycium barbarum
 
dc.subjectMice
 
dc.subjectPolysaccharides
 
dc.subjectRats
 
dc.subjectReproductive function
 
dc.subjectSexual behavior
 
dc.subjectSexual hormones
 
dc.subjectTestis
 
dc.subjectTraditional Chinese medicine
 
dc.titleLycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H 2O 2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Wuhan University
  3. Huazhong Agricultural University