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Article: Kinetics of cell growth and secondary metabolism of a high-tanshinone-producing line of the Ti transformed Salvia miltiorrhiza cells in suspension culture

TitleKinetics of cell growth and secondary metabolism of a high-tanshinone-producing line of the Ti transformed Salvia miltiorrhiza cells in suspension culture
Authors
KeywordsLithospermic acid B
Rosmarinic acid
Salvia miltiorrhiza
Secondary metabolism
Tanshinones
Issue Date1999
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0141-5492
Citation
Biotechnology Letters, 1999, v. 21 n. 8, p. 701-705 How to Cite?
AbstractWhen cultivated in 6,7-V medium in suspension culture, Salvia miltiorrhiza, transformed with Agrobacterium tumefaciens C58, grew rapidly, reaching about 9.7 g l-1 dry wt after 12 days. The cell line produced tanshinones: 150 mg cryptotanshinone, 20 mg tanshinone I and 50 mg tanshinone IIA/l and phenolic acids: 530 mg rosmarinic acid and 216 mg lithospermic acid B/l. The phenolic acids were intracellular while about 1/3 of the tanshinones were extracellular. This is the first report of simultaneous production of both phenolic acids and tanshinones in a single culture system.
Persistent Identifierhttp://hdl.handle.net/10722/68412
ISSN
2015 Impact Factor: 1.639
2015 SCImago Journal Rankings: 0.591
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Hen_HK
dc.contributor.authorChen, Fen_HK
dc.date.accessioned2010-09-06T06:04:23Z-
dc.date.available2010-09-06T06:04:23Z-
dc.date.issued1999en_HK
dc.identifier.citationBiotechnology Letters, 1999, v. 21 n. 8, p. 701-705en_HK
dc.identifier.issn0141-5492en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68412-
dc.description.abstractWhen cultivated in 6,7-V medium in suspension culture, Salvia miltiorrhiza, transformed with Agrobacterium tumefaciens C58, grew rapidly, reaching about 9.7 g l-1 dry wt after 12 days. The cell line produced tanshinones: 150 mg cryptotanshinone, 20 mg tanshinone I and 50 mg tanshinone IIA/l and phenolic acids: 530 mg rosmarinic acid and 216 mg lithospermic acid B/l. The phenolic acids were intracellular while about 1/3 of the tanshinones were extracellular. This is the first report of simultaneous production of both phenolic acids and tanshinones in a single culture system.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0141-5492en_HK
dc.relation.ispartofBiotechnology Lettersen_HK
dc.subjectLithospermic acid Ben_HK
dc.subjectRosmarinic aciden_HK
dc.subjectSalvia miltiorrhizaen_HK
dc.subjectSecondary metabolismen_HK
dc.subjectTanshinonesen_HK
dc.titleKinetics of cell growth and secondary metabolism of a high-tanshinone-producing line of the Ti transformed Salvia miltiorrhiza cells in suspension cultureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0141-5492&volume=21&issue=8&spage=701&epage=705&date=1999&atitle=Kinetics+of+cell+growth+and+secondary+metabolism+of+a+high-tanshinone-producing+line+of+the+Ti+transformed+Salvia+miltiorrhiza+cells+in+suspension+culturesen_HK
dc.identifier.emailChen, F: sfchen@hku.hken_HK
dc.identifier.authorityChen, F=rp00672en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1023/A:1005562410037en_HK
dc.identifier.scopuseid_2-s2.0-0032855016en_HK
dc.identifier.hkuros52992en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032855016&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue8en_HK
dc.identifier.spage701en_HK
dc.identifier.epage705en_HK
dc.identifier.isiWOS:000082440800011-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChen, H=26642984400en_HK
dc.identifier.scopusauthoridChen, F=7404907980en_HK

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