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Article: High density cultivation of Panax notoginseng cells in stirred bioreactors for the production of ginseng biomass and ginseng saponin

TitleHigh density cultivation of Panax notoginseng cells in stirred bioreactors for the production of ginseng biomass and ginseng saponin
Authors
KeywordsCentrifugal impeller bioreactor
Ginseng saponin
High density cell cultivation
Panax notoginseng
Plant cell suspension culture
Plant-specific valuable metabolite production
Issue Date1999
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/procbio
Citation
Process Biochemistry, 1999, v. 35 n. 5, p. 491-496 How to Cite?
AbstractA novel centrifugal impeller bioreactor (Wang SJ, Zhong JJ. A novel centrifugal impeller bioreactor. I. Fluid circulation, mixing and liquid velocity profiles, Biotechnol. Bioeng. 1996;51:511-519) was used for high- density suspension cultivation of Panax notoginseng cells and its performance was compared with a conventional turbine reactor and a shake flask. The maximum cell density reached 28.9, 26.0 and 22.7 g/l (by dry weight) in the shake flask (SF), centrifugal impeller bioreactor (CIB) and turbine reactor (TR), respectively; and their corresponding biomass productivity was 1103, 900 and 822 mg/(1-day). The total production of ginseng saponin reached about 0.92, 0.80, and 0.49 g/l in the SF, CIB and TR, respectively, and their corresponding saponin productivity was 34, 29 and 21 mg/(1-day). High cell densities (> 20 g/l) of P. notoginseng cells were produced in the stirred reactors. It can be concluded that from the viewpoint of biomass production and saponin accumulation, the CIB was better than the TR, and the flask culture results can be well reproduced in the CIB.
Persistent Identifierhttp://hdl.handle.net/10722/68406
ISSN
2015 Impact Factor: 2.529
2015 SCImago Journal Rankings: 0.937
References

 

DC FieldValueLanguage
dc.contributor.authorZhong, JJen_HK
dc.contributor.authorChen, Fen_HK
dc.contributor.authorHu, WWen_HK
dc.date.accessioned2010-09-06T06:04:20Z-
dc.date.available2010-09-06T06:04:20Z-
dc.date.issued1999en_HK
dc.identifier.citationProcess Biochemistry, 1999, v. 35 n. 5, p. 491-496en_HK
dc.identifier.issn1359-5113en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68406-
dc.description.abstractA novel centrifugal impeller bioreactor (Wang SJ, Zhong JJ. A novel centrifugal impeller bioreactor. I. Fluid circulation, mixing and liquid velocity profiles, Biotechnol. Bioeng. 1996;51:511-519) was used for high- density suspension cultivation of Panax notoginseng cells and its performance was compared with a conventional turbine reactor and a shake flask. The maximum cell density reached 28.9, 26.0 and 22.7 g/l (by dry weight) in the shake flask (SF), centrifugal impeller bioreactor (CIB) and turbine reactor (TR), respectively; and their corresponding biomass productivity was 1103, 900 and 822 mg/(1-day). The total production of ginseng saponin reached about 0.92, 0.80, and 0.49 g/l in the SF, CIB and TR, respectively, and their corresponding saponin productivity was 34, 29 and 21 mg/(1-day). High cell densities (> 20 g/l) of P. notoginseng cells were produced in the stirred reactors. It can be concluded that from the viewpoint of biomass production and saponin accumulation, the CIB was better than the TR, and the flask culture results can be well reproduced in the CIB.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/procbioen_HK
dc.relation.ispartofProcess Biochemistryen_HK
dc.rightsProcess Biochemistry. Copyright © Elsevier Ltd.en_HK
dc.subjectCentrifugal impeller bioreactoren_HK
dc.subjectGinseng saponinen_HK
dc.subjectHigh density cell cultivationen_HK
dc.subjectPanax notoginsengen_HK
dc.subjectPlant cell suspension cultureen_HK
dc.subjectPlant-specific valuable metabolite productionen_HK
dc.titleHigh density cultivation of Panax notoginseng cells in stirred bioreactors for the production of ginseng biomass and ginseng saponinen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1359-5113&volume=35&spage=491&epage=496&date=1999&atitle=High+density+cultivation+of+Panax+notoginseng+cells+in+stirred+bioreactors+for+the+production+of+ginseng+biomass+and+ginseng+saponinen_HK
dc.identifier.emailChen, F: sfchen@hku.hken_HK
dc.identifier.authorityChen, F=rp00672en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0032-9592(99)00095-3en_HK
dc.identifier.scopuseid_2-s2.0-0032726166en_HK
dc.identifier.hkuros52933en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032726166&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue5en_HK
dc.identifier.spage491en_HK
dc.identifier.epage496en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZhong, JJ=7201488646en_HK
dc.identifier.scopusauthoridChen, F=7404907980en_HK
dc.identifier.scopusauthoridHu, WW=46361258100en_HK

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