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Article: Quantitative analysis of anticancer 3-deoxyanthocyanidins in infected sorghum seedlings

TitleQuantitative analysis of anticancer 3-deoxyanthocyanidins in infected sorghum seedlings
Authors
Keywords3-deoxyanthocyanidins
Apigeninidin
LC-MRM
Luteolinidin
MALDI-TOF
Sorghum bicolor
Issue Date2007
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau
Citation
Journal Of Agricultural And Food Chemistry, 2007, v. 55 n. 2, p. 254-259 How to Cite?
Abstract3-Deoxyanthocyanidins are structurally related to the anthocyanin pigments, which are popular as health-promoting phytochemicals. Here, it is demonstrated that the 3-deoxyanthocyanidins are more cytotoxic on human cancer cells than the 3-hydroxylated anthocyanidin analogues. At 200 μM concentration, luteolinidin reduced the viability of HL-60 and HepG2 cells by 90 and 50%, respectively. Sorghum is a major source of 3-deoxyanthocyanidins, which are present as seed pigments and as phytoalexins responding to pathogen attack. On the basis of the collision-induced dissociation spectra of luteolinidin and apigeninidin, an LC-MS/MS method, operating in multiple-reaction monitoring mode, was developed for the specific detection and accurate quantification of these compounds in complex mixtures, which may be difficult to analyze using absorbance measurements. The results demonstrated that inoculated sorghum seedlings could be utilized for convenient and large-scale production of 3-deoxyanthocyanidins. A quantity of almost 270 μg/g (fresh weight) of luteolinidin was produced 72 h after fungal inoculation of 1-week-old seedlings. © 2007 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/68343
ISSN
2015 Impact Factor: 2.857
2015 SCImago Journal Rankings: 1.246
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShih, CHen_HK
dc.contributor.authorSiu, SOen_HK
dc.contributor.authorNg, Ren_HK
dc.contributor.authorWong, Een_HK
dc.contributor.authorChiu, LCMen_HK
dc.contributor.authorChu, IKen_HK
dc.contributor.authorLo, Cen_HK
dc.date.accessioned2010-09-06T06:03:45Z-
dc.date.available2010-09-06T06:03:45Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Agricultural And Food Chemistry, 2007, v. 55 n. 2, p. 254-259en_HK
dc.identifier.issn0021-8561en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68343-
dc.description.abstract3-Deoxyanthocyanidins are structurally related to the anthocyanin pigments, which are popular as health-promoting phytochemicals. Here, it is demonstrated that the 3-deoxyanthocyanidins are more cytotoxic on human cancer cells than the 3-hydroxylated anthocyanidin analogues. At 200 μM concentration, luteolinidin reduced the viability of HL-60 and HepG2 cells by 90 and 50%, respectively. Sorghum is a major source of 3-deoxyanthocyanidins, which are present as seed pigments and as phytoalexins responding to pathogen attack. On the basis of the collision-induced dissociation spectra of luteolinidin and apigeninidin, an LC-MS/MS method, operating in multiple-reaction monitoring mode, was developed for the specific detection and accurate quantification of these compounds in complex mixtures, which may be difficult to analyze using absorbance measurements. The results demonstrated that inoculated sorghum seedlings could be utilized for convenient and large-scale production of 3-deoxyanthocyanidins. A quantity of almost 270 μg/g (fresh weight) of luteolinidin was produced 72 h after fungal inoculation of 1-week-old seedlings. © 2007 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcauen_HK
dc.relation.ispartofJournal of Agricultural and Food Chemistryen_HK
dc.subject3-deoxyanthocyanidinsen_HK
dc.subjectApigeninidinen_HK
dc.subjectLC-MRMen_HK
dc.subjectLuteolinidinen_HK
dc.subjectMALDI-TOFen_HK
dc.subjectSorghum bicoloren_HK
dc.titleQuantitative analysis of anticancer 3-deoxyanthocyanidins in infected sorghum seedlingsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-8561&volume=55&spage=254&epage=259&date=2007&atitle=Quantitative+analysis+of+anticancer+3-deoxyanthocyanidins+in+infected+sorghum+seedlingsen_HK
dc.identifier.emailChu, IK: ivankchu@hku.hken_HK
dc.identifier.emailLo, C: clivelo@hkucc.hku.hken_HK
dc.identifier.authorityChu, IK=rp00683en_HK
dc.identifier.authorityLo, C=rp00751en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/jf062516ten_HK
dc.identifier.pmid17227050-
dc.identifier.scopuseid_2-s2.0-34047198392en_HK
dc.identifier.hkuros125258en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34047198392&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume55en_HK
dc.identifier.issue2en_HK
dc.identifier.spage254en_HK
dc.identifier.epage259en_HK
dc.identifier.isiWOS:000243503900010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridShih, CH=55233136000en_HK
dc.identifier.scopusauthoridSiu, SO=36905820500en_HK
dc.identifier.scopusauthoridNg, R=7102153790en_HK
dc.identifier.scopusauthoridWong, E=8234468400en_HK
dc.identifier.scopusauthoridChiu, LCM=7103129041en_HK
dc.identifier.scopusauthoridChu, IK=7103327484en_HK
dc.identifier.scopusauthoridLo, C=15737175700en_HK

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