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Article: Secretin, a known gastrointestinal peptide, is widely expressed during mouse embryonic development

TitleSecretin, a known gastrointestinal peptide, is widely expressed during mouse embryonic development
Authors
KeywordsBrain
Development
Embryo
Heart
Immunohistochemistry
In situ hybridization
Intestine
Kidney
Mouse
Secretin
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/modgep
Citation
Gene Expression Patterns, 2005, v. 5 n. 3, p. 445-451 How to Cite?
AbstractThe gastrointestinal functions of the 27-amino acid secretin peptide have been well established. In previous prenatal studies, secretin expression in the rat duodenum was reported after day 17 of gestation while its expression in other organs and its functions in the developing embryos are still unknown. By in situ hybridization and immunohistochemical staining, secretin transcripts and peptides were found to be widely expressed in mouse embryos. Consistent with the idea that secretin is a brain-gut peptide, its expressions are present in several developing brain regions such as cephalic mesenchyme, cerebellar primordium and choroid plexus as well as the epithelial villi lining and inner circular muscle of the developing intestine. Other than these organs, secretin was also detected in the developing heart including the ventricular epicardium and myocardium and certain structures of the developing kidney like ureteric bud, collecting duct and glomerulus. These observations strongly suggest for a functional role of secretin during mouse embryonic development. © 2004 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68331
ISSN
2015 Impact Factor: 1.485
2015 SCImago Journal Rankings: 0.985
ISI Accession Number ID
References
Grants

 

DC FieldValueLanguage
dc.contributor.authorSiu, FKYen_HK
dc.contributor.authorSham, MHen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-09-06T06:03:34Z-
dc.date.available2010-09-06T06:03:34Z-
dc.date.issued2005en_HK
dc.identifier.citationGene Expression Patterns, 2005, v. 5 n. 3, p. 445-451en_HK
dc.identifier.issn1567-133Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/68331-
dc.description.abstractThe gastrointestinal functions of the 27-amino acid secretin peptide have been well established. In previous prenatal studies, secretin expression in the rat duodenum was reported after day 17 of gestation while its expression in other organs and its functions in the developing embryos are still unknown. By in situ hybridization and immunohistochemical staining, secretin transcripts and peptides were found to be widely expressed in mouse embryos. Consistent with the idea that secretin is a brain-gut peptide, its expressions are present in several developing brain regions such as cephalic mesenchyme, cerebellar primordium and choroid plexus as well as the epithelial villi lining and inner circular muscle of the developing intestine. Other than these organs, secretin was also detected in the developing heart including the ventricular epicardium and myocardium and certain structures of the developing kidney like ureteric bud, collecting duct and glomerulus. These observations strongly suggest for a functional role of secretin during mouse embryonic development. © 2004 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/modgepen_HK
dc.relation.ispartofGene Expression Patternsen_HK
dc.rightsGene Expression Patterns . Copyright © Elsevier BV.en_HK
dc.subjectBrainen_HK
dc.subjectDevelopmenten_HK
dc.subjectEmbryoen_HK
dc.subjectHearten_HK
dc.subjectImmunohistochemistryen_HK
dc.subjectIn situ hybridizationen_HK
dc.subjectIntestineen_HK
dc.subjectKidneyen_HK
dc.subjectMouseen_HK
dc.subjectSecretinen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBrain - embryology - metabolismen_HK
dc.subject.meshEmbryo, Mammalian - metabolismen_HK
dc.subject.meshEmbryonic Developmenten_HK
dc.subject.meshFemaleen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshIntestines - embryology - metabolismen_HK
dc.subject.meshMiceen_HK
dc.subject.meshSecretin - biosynthesisen_HK
dc.subject.meshTissue Distributionen_HK
dc.titleSecretin, a known gastrointestinal peptide, is widely expressed during mouse embryonic developmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1567-133X&volume=5&spage=445&epage=451&date=2005&atitle=Secretin,+a+known+gastrointestinal+peptide,+is+widely+expressed+during+mouse+embryonic+developmenten_HK
dc.identifier.emailSham, MH: mhsham@hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authoritySham, MH=rp00380en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.modgep.2004.09.001en_HK
dc.identifier.pmid15661652-
dc.identifier.scopuseid_2-s2.0-12344287038en_HK
dc.identifier.hkuros97201en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12344287038&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue3en_HK
dc.identifier.spage445en_HK
dc.identifier.epage451en_HK
dc.identifier.isiWOS:000226954200018-
dc.publisher.placeNetherlandsen_HK
dc.relation.projectSecretin as a neuropeptide-
dc.identifier.scopusauthoridSiu, FKY=6701518484en_HK
dc.identifier.scopusauthoridSham, MH=7003729109en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK

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