File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effect of high-fat meals and fatty acid saturation on postprandial levels of the hormones ghrelin and leptin in healthy men

TitleEffect of high-fat meals and fatty acid saturation on postprandial levels of the hormones ghrelin and leptin in healthy men
Authors
KeywordsGhrelin
High-fat
Lean men
Leptin
Postprandial
Saturated fatty acids
Issue Date2006
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ejcn
Citation
European Journal Of Clinical Nutrition, 2006, v. 60 n. 1, p. 77-84 How to Cite?
AbstractObjective: Ghrelin and leptin play a role in control of food intake and adiposity but mechanisms regulating these hormones in man are poorly defined and evidence that dietary fats may have adverse effects is inconclusive. We investigated whether high-fat meals, which differed in saturated fatty acid (SFA) content acutely modified these hormones. Design: Randomised, double-blind, crossover trial. A high-fat (HF) test meal (59± 4 g fat; 71% of energy as fat) was given for breakfast on two occasions. Meals comprised either high (∼70:30) or low (∼ 55:45) saturated:unsaturated fatty acid (SFA:USFA) ratio. Fasting and postprandial measurements of serum total ghrelin (RIA), leptin (enzyme-linked immunosorbent assay (ELISA)) and insulin (RIA) were made over 6 h. Postprandial measurements were also made at 10 and 24 h following a fat-exclusion lunch, snack and dinner. Subjects: A total of 18 lean, healthy men. Results: There was no significant effect of the fatty meal (time, P>0.05), nor a differential effect of SFA:USFA ratio (treatment *time, P>0.05) on ghrelin over 6 h. Leptin decreased in response to both HF treatments (time, P<0.001) but increased SFA content did not further inhibit hormone secretion (treatment*time, P>0.05). There was no significant correlation between ghrelin or leptin and circulating insulin (P>0.05). Conclusion: We conclude that HF diets may adversely effect serum leptin, although the circadian decrease may account in part for this response. Increasing dietary SFAs had no deleterious effects on leptin or total ghrelin. © 2006 Nature Publishing Group. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68327
ISSN
2015 Impact Factor: 2.935
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPoppitt, SDen_HK
dc.contributor.authorLeahy, FEen_HK
dc.contributor.authorKeogh, GFen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorMulvey, TBen_HK
dc.contributor.authorStojkovic, Men_HK
dc.contributor.authorChan, YKen_HK
dc.contributor.authorChoong, YSen_HK
dc.contributor.authorMcArdle, BHen_HK
dc.contributor.authorCooper, GJSen_HK
dc.date.accessioned2010-09-06T06:03:32Z-
dc.date.available2010-09-06T06:03:32Z-
dc.date.issued2006en_HK
dc.identifier.citationEuropean Journal Of Clinical Nutrition, 2006, v. 60 n. 1, p. 77-84en_HK
dc.identifier.issn0954-3007en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68327-
dc.description.abstractObjective: Ghrelin and leptin play a role in control of food intake and adiposity but mechanisms regulating these hormones in man are poorly defined and evidence that dietary fats may have adverse effects is inconclusive. We investigated whether high-fat meals, which differed in saturated fatty acid (SFA) content acutely modified these hormones. Design: Randomised, double-blind, crossover trial. A high-fat (HF) test meal (59± 4 g fat; 71% of energy as fat) was given for breakfast on two occasions. Meals comprised either high (∼70:30) or low (∼ 55:45) saturated:unsaturated fatty acid (SFA:USFA) ratio. Fasting and postprandial measurements of serum total ghrelin (RIA), leptin (enzyme-linked immunosorbent assay (ELISA)) and insulin (RIA) were made over 6 h. Postprandial measurements were also made at 10 and 24 h following a fat-exclusion lunch, snack and dinner. Subjects: A total of 18 lean, healthy men. Results: There was no significant effect of the fatty meal (time, P>0.05), nor a differential effect of SFA:USFA ratio (treatment *time, P>0.05) on ghrelin over 6 h. Leptin decreased in response to both HF treatments (time, P<0.001) but increased SFA content did not further inhibit hormone secretion (treatment*time, P>0.05). There was no significant correlation between ghrelin or leptin and circulating insulin (P>0.05). Conclusion: We conclude that HF diets may adversely effect serum leptin, although the circadian decrease may account in part for this response. Increasing dietary SFAs had no deleterious effects on leptin or total ghrelin. © 2006 Nature Publishing Group. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ejcnen_HK
dc.relation.ispartofEuropean Journal of Clinical Nutritionen_HK
dc.subjectGhrelinen_HK
dc.subjectHigh-faten_HK
dc.subjectLean menen_HK
dc.subjectLeptinen_HK
dc.subjectPostprandialen_HK
dc.subjectSaturated fatty acidsen_HK
dc.titleEffect of high-fat meals and fatty acid saturation on postprandial levels of the hormones ghrelin and leptin in healthy menen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0954-3007&volume=60&spage=77&epage=84&date=2006&atitle=Effect+of+high-fat+meals+and+fatty+acid+saturation+on+postprandial+levels+of+the+hormones+ghrelin+and+leptin+in+healthy+men.en_HK
dc.identifier.emailWang, Y: yuwanghk@hku.hken_HK
dc.identifier.authorityWang, Y=rp00239en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.ejcn.1602270en_HK
dc.identifier.pmid16118648en_HK
dc.identifier.scopuseid_2-s2.0-33645837006en_HK
dc.identifier.hkuros120063en_HK
dc.identifier.hkuros108931-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645837006&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume60en_HK
dc.identifier.issue1en_HK
dc.identifier.spage77en_HK
dc.identifier.epage84en_HK
dc.identifier.isiWOS:000235010900011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPoppitt, SD=7004592052en_HK
dc.identifier.scopusauthoridLeahy, FE=7003739497en_HK
dc.identifier.scopusauthoridKeogh, GF=7004386410en_HK
dc.identifier.scopusauthoridWang, Y=34973733700en_HK
dc.identifier.scopusauthoridMulvey, TB=7003519653en_HK
dc.identifier.scopusauthoridStojkovic, M=12809104900en_HK
dc.identifier.scopusauthoridChan, YK=8613931200en_HK
dc.identifier.scopusauthoridChoong, YS=36797592700en_HK
dc.identifier.scopusauthoridMcArdle, BH=7005760191en_HK
dc.identifier.scopusauthoridCooper, GJS=7402355946en_HK
dc.identifier.citeulike302610-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats