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Conference Paper: Regeneration of intervertebral disc by mesenchymal stem cells: Potentials, limitations, and future direction

TitleRegeneration of intervertebral disc by mesenchymal stem cells: Potentials, limitations, and future direction
Authors
KeywordsIntervertebral disc degeneration
Intervertebral disc regeneration
Mesenchymal stem cells
Tissue engineering
Issue Date2006
PublisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/586
Citation
European Spine Journal, 2006, v. 15 SUPPL. 3, p. S406-S413 How to Cite?
AbstractOver the past few years, substantial progress has been made in the field of stem cell regeneration of the intervertebral disc. Autogenic mesenchymal stem cells in animal models can arrest intervertebral disc degeneration or even partially regenerate it and the effect is suggested to be dependent on the severity of degeneration. Mesenchymal stem cells (MSCs) are able to escape alloantigen recognition which is an advantage for allogenic transplantation. A number of injectable scaffolds have been described and various methods to pre-modulate MSCs' activity have been tested. In future, work will need to address the use of mesenchymal stem cells in large animal models and the fate of the implanted mesenchymal stem cells, particularly in the long term, in animals. This review examines the state-of-the-art in the field of stem cell regeneration of the intervertebral disc, and critically discusses, with scientific support, the issues involved, before stem cells could be used in human subjects. © Springer-Verlag 2006.
Persistent Identifierhttp://hdl.handle.net/10722/68307
ISSN
2015 Impact Factor: 2.132
2015 SCImago Journal Rankings: 0.972
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, VYLen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorCheung, KMCen_HK
dc.date.accessioned2010-09-06T06:03:20Z-
dc.date.available2010-09-06T06:03:20Z-
dc.date.issued2006en_HK
dc.identifier.citationEuropean Spine Journal, 2006, v. 15 SUPPL. 3, p. S406-S413en_HK
dc.identifier.issn0940-6719en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68307-
dc.description.abstractOver the past few years, substantial progress has been made in the field of stem cell regeneration of the intervertebral disc. Autogenic mesenchymal stem cells in animal models can arrest intervertebral disc degeneration or even partially regenerate it and the effect is suggested to be dependent on the severity of degeneration. Mesenchymal stem cells (MSCs) are able to escape alloantigen recognition which is an advantage for allogenic transplantation. A number of injectable scaffolds have been described and various methods to pre-modulate MSCs' activity have been tested. In future, work will need to address the use of mesenchymal stem cells in large animal models and the fate of the implanted mesenchymal stem cells, particularly in the long term, in animals. This review examines the state-of-the-art in the field of stem cell regeneration of the intervertebral disc, and critically discusses, with scientific support, the issues involved, before stem cells could be used in human subjects. © Springer-Verlag 2006.en_HK
dc.languageengen_HK
dc.publisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/586en_HK
dc.relation.ispartofEuropean Spine Journalen_HK
dc.subjectIntervertebral disc degenerationen_HK
dc.subjectIntervertebral disc regenerationen_HK
dc.subjectMesenchymal stem cellsen_HK
dc.subjectTissue engineeringen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIntervertebral Disc - cytology - physiology - surgeryen_HK
dc.subject.meshIntervertebral Disc Displacement - therapyen_HK
dc.subject.meshMesenchymal Stem Cell Transplantation - methods - trendsen_HK
dc.subject.meshMesoderm - cytology - physiologyen_HK
dc.subject.meshModels, Animalen_HK
dc.subject.meshRegeneration - physiologyen_HK
dc.subject.meshStem Cells - cytology - physiologyen_HK
dc.subject.meshTissue Engineering - methods - trendsen_HK
dc.titleRegeneration of intervertebral disc by mesenchymal stem cells: Potentials, limitations, and future directionen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0940-6719&volume=15 Suppl 15&spage=406&epage=13&date=2006&atitle=Regeneration+of+intervertebral+disc+by+mesenchymal+stem+cells:+Potentials,+limitations,+and+future+directionen_HK
dc.identifier.emailLeung, VYL: vicleung@hku.hken_HK
dc.identifier.emailChan, D: chand@hkucc.hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.authorityLeung, VYL=rp01764en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00586-006-0183-zen_HK
dc.identifier.pmid16845553en_HK
dc.identifier.scopuseid_2-s2.0-33748573686en_HK
dc.identifier.hkuros116093en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748573686&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issueSUPPL. 3en_HK
dc.identifier.spageS406en_HK
dc.identifier.epageS413en_HK
dc.identifier.isiWOS:000241321100015-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridLeung, VYL=35337438900en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK

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