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Conference Paper: Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction
Title | Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction |
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Authors | |
Keywords | Intervertebral disc degeneration Intervertebral disc regeneration Mesenchymal stem cells Tissue engineering |
Issue Date | 2006 |
Publisher | Springer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/586 |
Citation | The 2006 Meeting on The Lumbar Intervertebral Disc - From Basic Science to Clinical Application. In European Spine Journal, 2006, v. 15 n. 3 suppl., p. S406-S413 How to Cite? |
Abstract | Over the past few years, substantial progress has been made in the field of stem cell regeneration of the intervertebral disc. Autogenic mesenchymal stem cells in animal models can arrest intervertebral disc degeneration or even partially regenerate it and the effect is suggested to be dependent on the severity of degeneration. Mesenchymal stem cells (MSCs) are able to escape alloantigen recognition which is an advantage for allogenic transplantation. A number of injectable scaffolds have been described and various methods to pre-modulate MSCs' activity have been tested. In future, work will need to address the use of mesenchymal stem cells in large animal models and the fate of the implanted mesenchymal stem cells, particularly in the long term, in animals. This review examines the state-of-the-art in the field of stem cell regeneration of the intervertebral disc, and critically discusses, with scientific support, the issues involved, before stem cells could be used in human subjects. © Springer-Verlag 2006. |
Persistent Identifier | http://hdl.handle.net/10722/68307 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 1.042 |
PubMed Central ID | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leung, VYL | en_HK |
dc.contributor.author | Chan, D | en_HK |
dc.contributor.author | Cheung, KMC | en_HK |
dc.date.accessioned | 2010-09-06T06:03:20Z | - |
dc.date.available | 2010-09-06T06:03:20Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | The 2006 Meeting on The Lumbar Intervertebral Disc - From Basic Science to Clinical Application. In European Spine Journal, 2006, v. 15 n. 3 suppl., p. S406-S413 | en_HK |
dc.identifier.issn | 0940-6719 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/68307 | - |
dc.description.abstract | Over the past few years, substantial progress has been made in the field of stem cell regeneration of the intervertebral disc. Autogenic mesenchymal stem cells in animal models can arrest intervertebral disc degeneration or even partially regenerate it and the effect is suggested to be dependent on the severity of degeneration. Mesenchymal stem cells (MSCs) are able to escape alloantigen recognition which is an advantage for allogenic transplantation. A number of injectable scaffolds have been described and various methods to pre-modulate MSCs' activity have been tested. In future, work will need to address the use of mesenchymal stem cells in large animal models and the fate of the implanted mesenchymal stem cells, particularly in the long term, in animals. This review examines the state-of-the-art in the field of stem cell regeneration of the intervertebral disc, and critically discusses, with scientific support, the issues involved, before stem cells could be used in human subjects. © Springer-Verlag 2006. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Springer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/586 | en_HK |
dc.relation.ispartof | European Spine Journal | en_HK |
dc.subject | Intervertebral disc degeneration | en_HK |
dc.subject | Intervertebral disc regeneration | en_HK |
dc.subject | Mesenchymal stem cells | en_HK |
dc.subject | Tissue engineering | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Intervertebral Disc - cytology - physiology - surgery | en_HK |
dc.subject.mesh | Intervertebral Disc Displacement - therapy | en_HK |
dc.subject.mesh | Mesenchymal Stem Cell Transplantation - methods - trends | en_HK |
dc.subject.mesh | Mesoderm - cytology - physiology | en_HK |
dc.subject.mesh | Models, Animal | en_HK |
dc.subject.mesh | Regeneration - physiology | en_HK |
dc.subject.mesh | Stem Cells - cytology - physiology | en_HK |
dc.subject.mesh | Tissue Engineering - methods - trends | en_HK |
dc.title | Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0940-6719&volume=15 Suppl 15&spage=406&epage=13&date=2006&atitle=Regeneration+of+intervertebral+disc+by+mesenchymal+stem+cells:+Potentials,+limitations,+and+future+direction | en_HK |
dc.identifier.email | Leung, VYL: vicleung@hku.hk | en_HK |
dc.identifier.email | Chan, D: chand@hkucc.hku.hk | en_HK |
dc.identifier.email | Cheung, KMC: cheungmc@hku.hk | en_HK |
dc.identifier.authority | Leung, VYL=rp01764 | en_HK |
dc.identifier.authority | Chan, D=rp00540 | en_HK |
dc.identifier.authority | Cheung, KMC=rp00387 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1007/s00586-006-0183-z | en_HK |
dc.identifier.pmid | 16845553 | en_HK |
dc.identifier.pmcid | PMC2335386 | - |
dc.identifier.scopus | eid_2-s2.0-33748573686 | en_HK |
dc.identifier.hkuros | 116093 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33748573686&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 15 | en_HK |
dc.identifier.issue | 3 suppl. | en_HK |
dc.identifier.spage | S406 | en_HK |
dc.identifier.epage | S413 | en_HK |
dc.identifier.isi | WOS:000241321100015 | - |
dc.publisher.place | Germany | en_HK |
dc.identifier.scopusauthorid | Leung, VYL=35337438900 | en_HK |
dc.identifier.scopusauthorid | Chan, D=7402216545 | en_HK |
dc.identifier.scopusauthorid | Cheung, KMC=7402406754 | en_HK |
dc.customcontrol.immutable | sml 170109 amended | - |
dc.identifier.issnl | 0940-6719 | - |