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Article: Corticofugal modulation of acoustically induced Fos expression in the rat auditory pathway

TitleCorticofugal modulation of acoustically induced Fos expression in the rat auditory pathway
Authors
KeywordsActivity marker
Audition
Cochlear nucleus
Inferior colliculus
Medial geniculate body
Superior olive
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31248
Citation
Journal of Comparative Neurology, 2007, v. 501 n. 4, p. 509-525 How to Cite?
AbstractTo investigate the corticofugal modulation of acoustic information ascending through the auditory pathway of the rat, immunohistochemical techniques were used to study the functional expression of Fos protein in neurons. With auditory stimulation at different frequencies, Fos expression in the medial geniculate body (MGB), inferior colliculus (IC), superior olivary complex, and cochlear nucleus was examined, and the extent of Fos expression on the two sides was compared. Strikingly, we found densely Fos-labeled neurons in all divisions of the MGB after both presentation of an auditory stimulus and administration of a γ-aminobutyric acid type A (GABAA) antagonist (bicuculline methobromide; BIM) to the auditory cortex. The location of Fos-labeled neurons in the ventral division (MGv) after acoustic stimulation at different frequencies was in agreement with the known tonotopic organization. That no Fos-labeled neurons were found in the MGv with acoustic stimuli alone suggests that the transmission of ascending thalamocortical information is critically governed by corticofugal modulation. The dorsal (DCIC) and external cortices (ECIC) of the IC ipsilateral to the BIM-injected cortex showed a significantly higher number of Fos-labeled neurons than the contralateral IC. However, no difference in the number of Fos-labeled neurons was found between the central nucleus of the IC on either side, indicating that direct corticofugal modulation occurs only in the ECIC and DCIC. Further investigations are needed to assess the functional implications of the morphological differences observed between the descending corticofugal projections to the thalamus and the IC. © 2007 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/68287
ISSN
2015 Impact Factor: 3.331
2015 SCImago Journal Rankings: 2.345
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSun, Xen_HK
dc.contributor.authorXia, Qen_HK
dc.contributor.authorLia, CHen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorHe, Jen_HK
dc.date.accessioned2010-09-06T06:03:09Z-
dc.date.available2010-09-06T06:03:09Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal of Comparative Neurology, 2007, v. 501 n. 4, p. 509-525en_HK
dc.identifier.issn0021-9967en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68287-
dc.description.abstractTo investigate the corticofugal modulation of acoustic information ascending through the auditory pathway of the rat, immunohistochemical techniques were used to study the functional expression of Fos protein in neurons. With auditory stimulation at different frequencies, Fos expression in the medial geniculate body (MGB), inferior colliculus (IC), superior olivary complex, and cochlear nucleus was examined, and the extent of Fos expression on the two sides was compared. Strikingly, we found densely Fos-labeled neurons in all divisions of the MGB after both presentation of an auditory stimulus and administration of a γ-aminobutyric acid type A (GABAA) antagonist (bicuculline methobromide; BIM) to the auditory cortex. The location of Fos-labeled neurons in the ventral division (MGv) after acoustic stimulation at different frequencies was in agreement with the known tonotopic organization. That no Fos-labeled neurons were found in the MGv with acoustic stimuli alone suggests that the transmission of ascending thalamocortical information is critically governed by corticofugal modulation. The dorsal (DCIC) and external cortices (ECIC) of the IC ipsilateral to the BIM-injected cortex showed a significantly higher number of Fos-labeled neurons than the contralateral IC. However, no difference in the number of Fos-labeled neurons was found between the central nucleus of the IC on either side, indicating that direct corticofugal modulation occurs only in the ECIC and DCIC. Further investigations are needed to assess the functional implications of the morphological differences observed between the descending corticofugal projections to the thalamus and the IC. © 2007 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31248en_HK
dc.relation.ispartofJournal of Comparative Neurologyen_HK
dc.rightsThe Journal of Comparative Neurology. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectActivity markeren_HK
dc.subjectAuditionen_HK
dc.subjectCochlear nucleusen_HK
dc.subjectInferior colliculusen_HK
dc.subjectMedial geniculate bodyen_HK
dc.subjectSuperior oliveen_HK
dc.subject.meshAcoustic Stimulation - methodsen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAuditory Cortex - drug effects - metabolism - radiation effectsen_HK
dc.subject.meshAuditory Pathways - cytology - metabolism - radiation effectsen_HK
dc.subject.meshBicuculline - pharmacologyen_HK
dc.subject.meshBrain Mappingen_HK
dc.subject.meshCell Count - methodsen_HK
dc.subject.meshDose-Response Relationship, Radiationen_HK
dc.subject.meshFunctional Lateralityen_HK
dc.subject.meshGABA Antagonists - pharmacologyen_HK
dc.subject.meshGene Expression Regulation - drug effects - physiology - radiation effectsen_HK
dc.subject.meshImmunohistochemistry - methodsen_HK
dc.subject.meshInferior Colliculi - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshNeurons - metabolismen_HK
dc.subject.meshNumerical Analysis, Computer-Assisteden_HK
dc.subject.meshOncogene Proteins v-fos - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titleCorticofugal modulation of acoustically induced Fos expression in the rat auditory pathwayen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9967&volume=501&issue=4&spage=509&epage=25&date=2007&atitle=Corticofugal+modulation+of+acoustically+induced+Fos+expression+in+the+rat+auditory+pathway.en_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/cne.21249en_HK
dc.identifier.pmid17278128-
dc.identifier.scopuseid_2-s2.0-34247231059en_HK
dc.identifier.hkuros128899en_HK
dc.identifier.hkuros137661-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247231059&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume501en_HK
dc.identifier.issue4en_HK
dc.identifier.spage509en_HK
dc.identifier.epage525en_HK
dc.identifier.isiWOS:000244550400004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSun, X=7405621422en_HK
dc.identifier.scopusauthoridXia, Q=7202871577en_HK
dc.identifier.scopusauthoridLia, CH=16233310600en_HK
dc.identifier.scopusauthoridShum, DKY=7004824447en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.scopusauthoridHe, J=7404984971en_HK

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