File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts

TitleHOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts
Authors
KeywordsDifferentiation
HOXB5
Human embryonic gut
Migration
Neural crest cels
Issue Date2003
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38417
Citation
Developmental Dynamics, 2003, v. 228 n. 1, p. 1-10 How to Cite?
AbstractHOX genes from paralogous groups 4 and 5 are particularly relevant to the gut neuromusculature development because these genes are expressed at the splanchnic mesoderm surrounding the gut diverticulum, and at the level of the neural tube from where the vagal neural crest cells (NCCs) originate. In this study, we examined the migration and differentiation of NCCs, and investigated the expression patterns of HOXB5 in human embryonic guts. Human embryos of gestational week-4 to -8.5 were studied. Vagal NCCs enter the esophagus, migrate, and colonize the entire gut in a rostrocaudal manner between week-4 and week-7. The migrating NCCs in gut express HOXB5. Two separate and discontinuous mesenchymal expression domains of HOXB5 were detected in the gut: the distal domain preceding the migratory NCCs; and the proximal domain overlapping with the NCCs. The two expression domains shift caudally in parallel with the rostrocaudal migration of NCCs between week-4 and week-5. Neuron and glia differentiation of NCCs are concomitant with HOXB5 down-regulation in NCCs and the mesenchyme. By week-7, myenteric plexuses have formed; HOXB5 expression is switched on in the plexuses. We found that (1) the migratory route of NCCs in human embryonic gut was similar to that in mice and chicks; and (2) the expression pattern of HOXB5 correlated with the migration and differentiation of NCCs, suggesting a regulatory role of HOXB5 in the development of NCCs. © 2003 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/68284
ISSN
2015 Impact Factor: 2.198
2015 SCImago Journal Rankings: 1.726
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFu, Men_HK
dc.contributor.authorLui, VCHen_HK
dc.contributor.authorSham, MHen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T06:03:07Z-
dc.date.available2010-09-06T06:03:07Z-
dc.date.issued2003en_HK
dc.identifier.citationDevelopmental Dynamics, 2003, v. 228 n. 1, p. 1-10en_HK
dc.identifier.issn1058-8388en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68284-
dc.description.abstractHOX genes from paralogous groups 4 and 5 are particularly relevant to the gut neuromusculature development because these genes are expressed at the splanchnic mesoderm surrounding the gut diverticulum, and at the level of the neural tube from where the vagal neural crest cells (NCCs) originate. In this study, we examined the migration and differentiation of NCCs, and investigated the expression patterns of HOXB5 in human embryonic guts. Human embryos of gestational week-4 to -8.5 were studied. Vagal NCCs enter the esophagus, migrate, and colonize the entire gut in a rostrocaudal manner between week-4 and week-7. The migrating NCCs in gut express HOXB5. Two separate and discontinuous mesenchymal expression domains of HOXB5 were detected in the gut: the distal domain preceding the migratory NCCs; and the proximal domain overlapping with the NCCs. The two expression domains shift caudally in parallel with the rostrocaudal migration of NCCs between week-4 and week-5. Neuron and glia differentiation of NCCs are concomitant with HOXB5 down-regulation in NCCs and the mesenchyme. By week-7, myenteric plexuses have formed; HOXB5 expression is switched on in the plexuses. We found that (1) the migratory route of NCCs in human embryonic gut was similar to that in mice and chicks; and (2) the expression pattern of HOXB5 correlated with the migration and differentiation of NCCs, suggesting a regulatory role of HOXB5 in the development of NCCs. © 2003 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38417en_HK
dc.relation.ispartofDevelopmental Dynamicsen_HK
dc.rightsDevelopmental Dynamics. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectDifferentiationen_HK
dc.subjectHOXB5en_HK
dc.subjectHuman embryonic guten_HK
dc.subjectMigrationen_HK
dc.subjectNeural crest celsen_HK
dc.subject.meshCell Differentiationen_HK
dc.subject.meshCell Movementen_HK
dc.subject.meshGene Expression Regulation, Developmentalen_HK
dc.subject.meshGenes, Homeoboxen_HK
dc.subject.meshHomeodomain Proteins - genetics - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIntestines - embryology - metabolismen_HK
dc.subject.meshMesodermen_HK
dc.subject.meshModels, Biologicalen_HK
dc.subject.meshNeural Crest - cytology - embryologyen_HK
dc.subject.meshNeurons - cytology - metabolismen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshVagus Nerve - cytology - embryologyen_HK
dc.titleHOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblastsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1058-8388&volume=228&issue=1&spage=1&epage=10&date=2003&atitle=HOXB5+expression+is+spatially+and+temporarily+regulated+in+human+embryonic+gut+during+neural+crest+cell+colonization+and+differentiation+of+enteric+neuroblastsen_HK
dc.identifier.emailLui, VCH: vchlui@hkucc.hku.hken_HK
dc.identifier.emailSham, MH: mhsham@hkucc.hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityLui, VCH=rp00363en_HK
dc.identifier.authoritySham, MH=rp00380en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1002/dvdy.10350en_HK
dc.identifier.pmid12950074-
dc.identifier.scopuseid_2-s2.0-0041857928en_HK
dc.identifier.hkuros82659en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0041857928&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume228en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage10en_HK
dc.identifier.isiWOS:000185106800001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFu, M=49761323800en_HK
dc.identifier.scopusauthoridLui, VCH=7004231344en_HK
dc.identifier.scopusauthoridSham, MH=7003729109en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats