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Article: Disrupted expression of matrix genes in the growth plate of the mouse cartilage matrix deficiency (cmd) mutant

TitleDisrupted expression of matrix genes in the growth plate of the mouse cartilage matrix deficiency (cmd) mutant
Authors
Issue Date1998
PublisherWiley-Liss. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/33773/?CRETRY=1&SRETRY=0
Citation
Developmental Genetics, 1998, v. 22 n. 4, p. 349-358 How to Cite?
AbstractChondrodysplasia in the autosomal recessive cartilage matrix deficiency (cmd) mutant is caused by lack of the proteoglycan aggrecan arising from a mutation in the gene. Homozygous cmd/cmd mice are characterized by disorganisation of chondrocytes in the growth plate, disproportionate dwarfism, cleft palate, and perinatal lethality. We have studied the impact of the aggrecan deficiency on the expression of other matrix genes during the differentiation of chondrocytes in the growth plate of cmd/cmd 18.5 day fetuses. Compared with the wild-type, there are significant differences in the growth plates of cmd mutants in the combinations of co-expression of genes encoding the glycoprotein link protein, proteoglycan syndecan 3, collagens α1(X) [Col 1Oa1], α2(XI) [Col 11a2], and the alternative transcripts of α (11) [Col2a1 type IIA form], and α1(IX) [Co1 9 a1 long and short forms]. The discordance of gene expression in cmd chondrocytes may be additional factors contributing to the disrupted cellular architecture of the growth plate resulting from the primary absence of aggrecan.
Persistent Identifierhttp://hdl.handle.net/10722/68250
ISSN
2001 Impact Factor: 3.301
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWai, AWKen_HK
dc.contributor.authorNg, LJen_HK
dc.contributor.authorWatanabe, Hen_HK
dc.contributor.authorYamada, Yen_HK
dc.contributor.authorTam, PPLen_HK
dc.contributor.authorCheah, KSEen_HK
dc.date.accessioned2010-09-06T06:02:47Z-
dc.date.available2010-09-06T06:02:47Z-
dc.date.issued1998en_HK
dc.identifier.citationDevelopmental Genetics, 1998, v. 22 n. 4, p. 349-358en_HK
dc.identifier.issn0192-253Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/68250-
dc.description.abstractChondrodysplasia in the autosomal recessive cartilage matrix deficiency (cmd) mutant is caused by lack of the proteoglycan aggrecan arising from a mutation in the gene. Homozygous cmd/cmd mice are characterized by disorganisation of chondrocytes in the growth plate, disproportionate dwarfism, cleft palate, and perinatal lethality. We have studied the impact of the aggrecan deficiency on the expression of other matrix genes during the differentiation of chondrocytes in the growth plate of cmd/cmd 18.5 day fetuses. Compared with the wild-type, there are significant differences in the growth plates of cmd mutants in the combinations of co-expression of genes encoding the glycoprotein link protein, proteoglycan syndecan 3, collagens α1(X) [Col 1Oa1], α2(XI) [Col 11a2], and the alternative transcripts of α (11) [Col2a1 type IIA form], and α1(IX) [Co1 9 a1 long and short forms]. The discordance of gene expression in cmd chondrocytes may be additional factors contributing to the disrupted cellular architecture of the growth plate resulting from the primary absence of aggrecan.en_HK
dc.languageengen_HK
dc.publisherWiley-Liss. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/33773/?CRETRY=1&SRETRY=0en_HK
dc.relation.ispartofDevelopmental Geneticsen_HK
dc.subject.meshAggrecansen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Differentiation - physiologyen_HK
dc.subject.meshChondrocytes - cytologyen_HK
dc.subject.meshChromosome Mappingen_HK
dc.subject.meshExostoses, Multiple Hereditary - geneticsen_HK
dc.subject.meshExtracellular Matrix Proteinsen_HK
dc.subject.meshGene Expression Regulation - physiologyen_HK
dc.subject.meshGenes, Recessiveen_HK
dc.subject.meshGrowth Plate - metabolismen_HK
dc.subject.meshLectins, C-Typeen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Mutant Strainsen_HK
dc.subject.meshProteoglycans - deficiency - geneticsen_HK
dc.titleDisrupted expression of matrix genes in the growth plate of the mouse cartilage matrix deficiency (cmd) mutanten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0192-253X&volume=22&spage=349&epage=358&date=1998&atitle=Disrupted+expression+of+matrix+genes+in+the+growth+plate+of+the+mouse+cartilage+matrix+deficiency+(cmd)+mutanten_HK
dc.identifier.emailCheah, KSE:hrmbdkc@hku.hken_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/(SICI)1520-6408(1998)22:4<349::AID-DVG5>3.0.CO;2-6en_HK
dc.identifier.pmid9664687-
dc.identifier.scopuseid_2-s2.0-0031803529en_HK
dc.identifier.hkuros36638en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031803529&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue4en_HK
dc.identifier.spage349en_HK
dc.identifier.epage358en_HK
dc.identifier.isiWOS:000074575900005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWai, AWK=6603455255en_HK
dc.identifier.scopusauthoridNg, LJ=7201477760en_HK
dc.identifier.scopusauthoridWatanabe, H=7410305531en_HK
dc.identifier.scopusauthoridYamada, Y=7407166140en_HK
dc.identifier.scopusauthoridTam, PPL=7202539412en_HK
dc.identifier.scopusauthoridCheah, KSE=35387746200en_HK

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