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Article: An externally fixed femoral fracture model for mice

TitleAn externally fixed femoral fracture model for mice
Authors
KeywordsExternal fixation
Femur
Fracture
Mechanical characterization
Mouse model
Issue Date2003
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres
Citation
Journal Of Orthopaedic Research, 2003, v. 21 n. 4, p. 685-690 How to Cite?
AbstractTransgenic and knockout mouse models can be used to help understand the molecular mechanisms of fracture repair. This study examines the feasibility of applying an external fixator to the mouse femur as one model for studying fracture repair. The external fixator consisted of two aluminum blocks connected by two rods. Four pins are used to connect the blocks to the bone. Mechanical characterization of the fixators was carried out prior to their use. Sixty-two wild type mice with bilateral femoral fractures were created using an open technique and fixed using the fixator. The progress of fracture healing was monitored radiologically before sacrifice and by mechanical testing and histology after sacrifice. Initially four mice died intraoperatively from excessive blood loss, the intraoperative mortality was subsequently reduced by subcutaneous saline infusion. The bone healed between 14 and 21 days after fracture and remodeled by 60 days. Both radiological and mechanical assessments showed a steady progression of bone healing. Histology demonstrated callus and endochondral bone formation. This study demonstrated that it is possible to create a mouse femoral fracture model stabilized by external fixation and will provide an additional model to the understanding of fracture healing in transgenic and knockout mice. © 2003 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68244
ISSN
2015 Impact Factor: 2.807
2015 SCImago Journal Rankings: 1.464
ISI Accession Number ID
References
Errata

 

DC FieldValueLanguage
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorKaluarachi, Ken_HK
dc.contributor.authorAndrew, Gen_HK
dc.contributor.authorLu, Wen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorCheah, KSEen_HK
dc.date.accessioned2010-09-06T06:02:44Z-
dc.date.available2010-09-06T06:02:44Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Orthopaedic Research, 2003, v. 21 n. 4, p. 685-690en_HK
dc.identifier.issn0736-0266en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68244-
dc.description.abstractTransgenic and knockout mouse models can be used to help understand the molecular mechanisms of fracture repair. This study examines the feasibility of applying an external fixator to the mouse femur as one model for studying fracture repair. The external fixator consisted of two aluminum blocks connected by two rods. Four pins are used to connect the blocks to the bone. Mechanical characterization of the fixators was carried out prior to their use. Sixty-two wild type mice with bilateral femoral fractures were created using an open technique and fixed using the fixator. The progress of fracture healing was monitored radiologically before sacrifice and by mechanical testing and histology after sacrifice. Initially four mice died intraoperatively from excessive blood loss, the intraoperative mortality was subsequently reduced by subcutaneous saline infusion. The bone healed between 14 and 21 days after fracture and remodeled by 60 days. Both radiological and mechanical assessments showed a steady progression of bone healing. Histology demonstrated callus and endochondral bone formation. This study demonstrated that it is possible to create a mouse femoral fracture model stabilized by external fixation and will provide an additional model to the understanding of fracture healing in transgenic and knockout mice. © 2003 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthresen_HK
dc.relation.ispartofJournal of Orthopaedic Researchen_HK
dc.rightsJournal of Orthopaedic Research. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectExternal fixationen_HK
dc.subjectFemuren_HK
dc.subjectFractureen_HK
dc.subjectMechanical characterizationen_HK
dc.subjectMouse modelen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBehavior, Animalen_HK
dc.subject.meshBiomechanicsen_HK
dc.subject.meshBody Weighten_HK
dc.subject.meshBony Callus - pathology - physiology - radiographyen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshExternal Fixatorsen_HK
dc.subject.meshFemoral Fractures - physiopathology - radiography - surgeryen_HK
dc.subject.meshMiceen_HK
dc.titleAn externally fixed femoral fracture model for miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0736-0266&volume=21&issue=4&spage=685&epage=690&date=2003&atitle=An+externally+fixed+femoral+fracture+model+for+miceen_HK
dc.identifier.emailCheung, KMC:cheungmc@hku.hken_HK
dc.identifier.emailLu, W:wwlu@hku.hken_HK
dc.identifier.emailChan, D:chand@hkucc.hku.hken_HK
dc.identifier.emailCheah, KSE:hrmbdkc@hku.hken_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityLu, W=rp00411en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0736-0266(03)00026-3en_HK
dc.identifier.pmid12798069-
dc.identifier.scopuseid_2-s2.0-0038545779en_HK
dc.identifier.hkuros79494en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038545779&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue4en_HK
dc.identifier.spage685en_HK
dc.identifier.epage690en_HK
dc.identifier.isiWOS:000183792200016-
dc.publisher.placeUnited Statesen_HK
dc.relation.erratumdoi:10.1016/S0736-0266(03)00086-X-
dc.relation.erratumeid:eid_2-s2.0-0037869410-
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridKaluarachi, K=8131017300en_HK
dc.identifier.scopusauthoridAndrew, G=7003579133en_HK
dc.identifier.scopusauthoridLu, W=7404215221en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.scopusauthoridCheah, KSE=35387746200en_HK

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