File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The mouse model and human disease

TitleThe mouse model and human disease
Authors
Issue Date2001
Citation
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 2001, v. 23 n. 1, p. 2-7 How to Cite?
AbstractThe mouse is an ideal model organism for studies of human disease, because mouse is physiologically very similar to human. Also, there is a large genetic reservoir of potential models of human diseases that has been generated. In addition, high-resolution genetic and physical linkage maps are now available and the sequence of mouse genome will be completed in the near future. Furthermore, the techniques necessary for the modification of mouse genome, such as transgenic and knockout techniques, and chromosome engineering methods have been established. These techniques enable us to introduce any mutations anywhere in the mouse genome. The methods for analyzing complex genetic diseases also have been developed. These advances facilitate the identification and cloning of mouse disease loci and the establishment of new models. It makes mouse the model organism of choice by academic and industrial researchers to study human diseases. In Part I of this review, we summarize the classical and modern approaches that provide the basis of establishing mouse model of human diseases. In the following parts, we will list more than 100 mouse models of human diseases. In most of these models, the mouse mutant phenotype closely resembles the human disease phenotype. These mouse models are valuable sources for the understanding of the human diseases and they can be used to develop strategies for prevention and treatment of the diseases.
Persistent Identifierhttp://hdl.handle.net/10722/68226
ISSN
2015 SCImago Journal Rankings: 0.151

 

DC FieldValueLanguage
dc.contributor.authorKung, HFen_HK
dc.contributor.authorHuang, JDen_HK
dc.date.accessioned2010-09-06T06:02:33Z-
dc.date.available2010-09-06T06:02:33Z-
dc.date.issued2001en_HK
dc.identifier.citationZhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 2001, v. 23 n. 1, p. 2-7en_HK
dc.identifier.issn1000-503Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/68226-
dc.description.abstractThe mouse is an ideal model organism for studies of human disease, because mouse is physiologically very similar to human. Also, there is a large genetic reservoir of potential models of human diseases that has been generated. In addition, high-resolution genetic and physical linkage maps are now available and the sequence of mouse genome will be completed in the near future. Furthermore, the techniques necessary for the modification of mouse genome, such as transgenic and knockout techniques, and chromosome engineering methods have been established. These techniques enable us to introduce any mutations anywhere in the mouse genome. The methods for analyzing complex genetic diseases also have been developed. These advances facilitate the identification and cloning of mouse disease loci and the establishment of new models. It makes mouse the model organism of choice by academic and industrial researchers to study human diseases. In Part I of this review, we summarize the classical and modern approaches that provide the basis of establishing mouse model of human diseases. In the following parts, we will list more than 100 mouse models of human diseases. In most of these models, the mouse mutant phenotype closely resembles the human disease phenotype. These mouse models are valuable sources for the understanding of the human diseases and they can be used to develop strategies for prevention and treatment of the diseases.en_HK
dc.languageengen_HK
dc.relation.ispartofZhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicaeen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshChromosome Mapping - methodsen_HK
dc.subject.meshDNA Mutational Analysis - methodsen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMice - geneticsen_HK
dc.subject.meshMice, Inbred Strainsen_HK
dc.subject.meshMice, Mutant Strainsen_HK
dc.subject.meshMice, Transgenicen_HK
dc.titleThe mouse model and human diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailHuang, JD:jdhuang@hkucc.hku.hken_HK
dc.identifier.authorityHuang, JD=rp00451en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12905807-
dc.identifier.scopuseid_2-s2.0-2542442956en_HK
dc.identifier.hkuros58502en_HK
dc.identifier.volume23en_HK
dc.identifier.issue1en_HK
dc.identifier.spage2en_HK
dc.identifier.epage7en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridHuang, JD=8108660600en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats