File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Expression of Trk receptors in otolith-related neurons in the vestibular nucleus of rats

TitleExpression of Trk receptors in otolith-related neurons in the vestibular nucleus of rats
Authors
KeywordsFos
Immunocytochemistry
Trk receptor
Utricle
Vestibular nuclei
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2005, v. 1062 n. 1-2, p. 92-100 How to Cite?
AbstractThe expression of the three Trk receptors (TrkA, TrkB, and TrkC) in otolith-related neurons within the vestibular nuclei of adult Sprague-Dawley rats was examined immunohistochemically. Conscious animals were subjected to sinusoidal linear acceleration along either the anterior-posterior (AP) or interaural (IA) axis on the horizontal plane. Neuronal activation was defined by Fos expression in cell nuclei. Control animals, viz labyrinthectomized rats subjected to stimulation and normal rats that remained stationary, showed only a few sporadically scattered Fos-labeled neurons. Among experimental rats, the number of Fos-labeled neurons and their distribution pattern in each vestibular subnucleus in animals stimulated along the antero-posterior axis were similar to those along the interaural axis. No apparent topography was observed among neurons activated along these two directions. Only about one-third of the Trk-immunoreactive neurons in the vestibular nucleus expressed Fos. Double-labeled Fos/TrkA, Fos/TrkB and Fos/TrkC neurons constituted 85-98% of the total number of Fos-labeled neurons in vestibular nuclear complex and its subgroups x and y. Our findings suggest that Trk receptors and their cognate neurotrophins in central otolith neurons may contribute to the modulation of gravity-related spatial information during horizontal head movements. © 2005 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68217
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, FXen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorTse, YCen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-06T06:02:28Z-
dc.date.available2010-09-06T06:02:28Z-
dc.date.issued2005en_HK
dc.identifier.citationBrain Research, 2005, v. 1062 n. 1-2, p. 92-100en_HK
dc.identifier.issn0006-8993en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68217-
dc.description.abstractThe expression of the three Trk receptors (TrkA, TrkB, and TrkC) in otolith-related neurons within the vestibular nuclei of adult Sprague-Dawley rats was examined immunohistochemically. Conscious animals were subjected to sinusoidal linear acceleration along either the anterior-posterior (AP) or interaural (IA) axis on the horizontal plane. Neuronal activation was defined by Fos expression in cell nuclei. Control animals, viz labyrinthectomized rats subjected to stimulation and normal rats that remained stationary, showed only a few sporadically scattered Fos-labeled neurons. Among experimental rats, the number of Fos-labeled neurons and their distribution pattern in each vestibular subnucleus in animals stimulated along the antero-posterior axis were similar to those along the interaural axis. No apparent topography was observed among neurons activated along these two directions. Only about one-third of the Trk-immunoreactive neurons in the vestibular nucleus expressed Fos. Double-labeled Fos/TrkA, Fos/TrkB and Fos/TrkC neurons constituted 85-98% of the total number of Fos-labeled neurons in vestibular nuclear complex and its subgroups x and y. Our findings suggest that Trk receptors and their cognate neurotrophins in central otolith neurons may contribute to the modulation of gravity-related spatial information during horizontal head movements. © 2005 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_HK
dc.relation.ispartofBrain Researchen_HK
dc.rightsBrain Research. Copyright © Elsevier BV.en_HK
dc.subjectFosen_HK
dc.subjectImmunocytochemistryen_HK
dc.subjectTrk receptoren_HK
dc.subjectUtricleen_HK
dc.subjectVestibular nucleien_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshGravity Sensing - physiologyen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshNeurons - metabolismen_HK
dc.subject.meshOtolithic Membrane - innervationen_HK
dc.subject.meshProprioception - physiologyen_HK
dc.subject.meshProto-Oncogene Proteins c-fos - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReceptor Protein-Tyrosine Kinases - metabolismen_HK
dc.subject.meshReceptor, trkA - metabolismen_HK
dc.subject.meshReceptor, trkB - metabolismen_HK
dc.subject.meshReceptor, trkC - metabolismen_HK
dc.subject.meshSaccule and Utricle - innervationen_HK
dc.subject.meshStatistics, Nonparametricen_HK
dc.subject.meshTissue Distributionen_HK
dc.subject.meshVestibular Nuclei - cytology - metabolismen_HK
dc.titleExpression of Trk receptors in otolith-related neurons in the vestibular nucleus of ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-8993&volume=1062&issue=1-2&spage=92&epage=100&date=2005&atitle=Expression+of+Trk+receptors+in+otolith-related+neurons+in+the+vestibular+nucleus+of+ratsen_HK
dc.identifier.emailLai, CH: chlaib@hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.brainres.2005.09.025en_HK
dc.identifier.pmid16256078-
dc.identifier.scopuseid_2-s2.0-27744453654en_HK
dc.identifier.hkuros121198en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27744453654&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1062en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage92en_HK
dc.identifier.epage100en_HK
dc.identifier.isiWOS:000233790500011-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridZhang, FX=7404969043en_HK
dc.identifier.scopusauthoridLai, CH=7403086597en_HK
dc.identifier.scopusauthoridTse, YC=7005116869en_HK
dc.identifier.scopusauthoridShum, DKY=7004824447en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats