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Article: Embryonic development of the ganglion plexuses and the concentric layer structure of human gut: A topographical study

TitleEmbryonic development of the ganglion plexuses and the concentric layer structure of human gut: A topographical study
Authors
KeywordsEnteric nervous system
Gastrointestinal tract
Human embryos
Neural crest
Smooth muscle
Issue Date2004
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00429/index.htm
Citation
Anatomy And Embryology, 2004, v. 208 n. 1, p. 33-41 How to Cite?
AbstractIn this study, we performed a detailed topographical study on the development of ganglion plexuses and the smooth muscle layers of human embryonic and fetal gut. Neuron and glia differentiation was investigated with anti-PGP9.5 and anti-S100 antibodies respectively. The differentiation of smooth muscle and interstitial cells of Cajal (ICC) was studied with anti-smooth muscle α-actin and anti-C-Kit antibodies respectively. By week 7, rostro-caudal neural crest cell (NCC) colonization of the gut was complete, and NCCs have differentiated into neurons and glia. At the foregut, neurons and glia were aggregated into ganglion plexus in the myenteric region, and the longitudinal and circular muscle layers have started to differentiate; however, neurons and glia were not found in the submucosa. At the hindgut, neurons and glia were dispersed within the mesenchyme. Myenteric plexus, longitudinal and circular muscle layers formed along the entire gut by week 9. Scattered and individual neurons and glia, and small ganglion plexuses were detected in the foregut and midgut submucosa by week 12. Ganglion plexus was not seen in the hindgut submucosa until week 14. Muscularis mucosae was formed at the foregut and midgut by week 12 but was only discernible at the hindgut 2 weeks later. As the gut wall developed, ganglion plexus increased in size with more neurons and glia, and the formation of intra-plexus nerve fascicle. ICCs were localized in the ganglion plexus as early as week 7. ICCs were initially dispersed in the plexus and were preferentially localized at the periphery of the plexus by week 20. The specification of the annular layers of human embryonic and fetal gut follows a strict spatio-temporal pattern in a rostro-caudal and centripetal manner suggesting that interaction between (1) homotypic and/or heterotypic cells; and (2) cells and the extracellular matrix is critical for the embryonic development of the gut mesenchyme and the enteric nervous system. © Springer-Verlag 2004.
Persistent Identifierhttp://hdl.handle.net/10722/68197
ISSN
2008 Impact Factor: 1.39
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFu, Men_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorSham, MHen_HK
dc.contributor.authorLui, VCHen_HK
dc.date.accessioned2010-09-06T06:02:17Z-
dc.date.available2010-09-06T06:02:17Z-
dc.date.issued2004en_HK
dc.identifier.citationAnatomy And Embryology, 2004, v. 208 n. 1, p. 33-41en_HK
dc.identifier.issn0340-2061en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68197-
dc.description.abstractIn this study, we performed a detailed topographical study on the development of ganglion plexuses and the smooth muscle layers of human embryonic and fetal gut. Neuron and glia differentiation was investigated with anti-PGP9.5 and anti-S100 antibodies respectively. The differentiation of smooth muscle and interstitial cells of Cajal (ICC) was studied with anti-smooth muscle α-actin and anti-C-Kit antibodies respectively. By week 7, rostro-caudal neural crest cell (NCC) colonization of the gut was complete, and NCCs have differentiated into neurons and glia. At the foregut, neurons and glia were aggregated into ganglion plexus in the myenteric region, and the longitudinal and circular muscle layers have started to differentiate; however, neurons and glia were not found in the submucosa. At the hindgut, neurons and glia were dispersed within the mesenchyme. Myenteric plexus, longitudinal and circular muscle layers formed along the entire gut by week 9. Scattered and individual neurons and glia, and small ganglion plexuses were detected in the foregut and midgut submucosa by week 12. Ganglion plexus was not seen in the hindgut submucosa until week 14. Muscularis mucosae was formed at the foregut and midgut by week 12 but was only discernible at the hindgut 2 weeks later. As the gut wall developed, ganglion plexus increased in size with more neurons and glia, and the formation of intra-plexus nerve fascicle. ICCs were localized in the ganglion plexus as early as week 7. ICCs were initially dispersed in the plexus and were preferentially localized at the periphery of the plexus by week 20. The specification of the annular layers of human embryonic and fetal gut follows a strict spatio-temporal pattern in a rostro-caudal and centripetal manner suggesting that interaction between (1) homotypic and/or heterotypic cells; and (2) cells and the extracellular matrix is critical for the embryonic development of the gut mesenchyme and the enteric nervous system. © Springer-Verlag 2004.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00429/index.htmen_HK
dc.relation.ispartofAnatomy and Embryologyen_HK
dc.subjectEnteric nervous systemen_HK
dc.subjectGastrointestinal tracten_HK
dc.subjectHuman embryosen_HK
dc.subjectNeural cresten_HK
dc.subjectSmooth muscleen_HK
dc.subject.meshActins - metabolismen_HK
dc.subject.meshEmbryo, Mammalian - anatomy & histology - metabolismen_HK
dc.subject.meshEmbryonic and Fetal Developmenten_HK
dc.subject.meshEnteric Nervous System - embryologyen_HK
dc.subject.meshGanglia - embryologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshIntestines - embryologyen_HK
dc.subject.meshMuscle, Smooth - embryologyen_HK
dc.subject.meshMyenteric Plexus - embryologyen_HK
dc.subject.meshS100 Proteins - metabolismen_HK
dc.subject.meshUbiquitin Thiolesterase - metabolismen_HK
dc.titleEmbryonic development of the ganglion plexuses and the concentric layer structure of human gut: A topographical studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0340-2061&volume=208&issue=1&spage=33&epage=41&date=2004&atitle=Embryonic+development+of+the+ganglion+plexuses+and+the+concentric+layer+structure+of+human+gut:+a+topographical+studyen_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.emailSham, MH: mhsham@hkucc.hku.hken_HK
dc.identifier.emailLui, VCH: vchlui@hkucc.hku.hken_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.identifier.authoritySham, MH=rp00380en_HK
dc.identifier.authorityLui, VCH=rp00363en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00429-003-0371-0en_HK
dc.identifier.pmid14991401-
dc.identifier.scopuseid_2-s2.0-2142750165en_HK
dc.identifier.hkuros88347en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2142750165&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume208en_HK
dc.identifier.issue1en_HK
dc.identifier.spage33en_HK
dc.identifier.epage41en_HK
dc.identifier.isiWOS:000220678200005-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridFu, M=49761323800en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK
dc.identifier.scopusauthoridSham, MH=7003729109en_HK
dc.identifier.scopusauthoridLui, VCH=7004231344en_HK

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