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Article: Sox2 is required for sensory organ development in the mammalian inner ear

TitleSox2 is required for sensory organ development in the mammalian inner ear
Authors
Issue Date2005
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 2005, v. 434 n. 7036, p. 1031-1035 How to Cite?
AbstractSensory hair cells and their associated non-sensory supporting cells in the inner ear are fundamental for hearing and balance. They arise from a common progenitor1, but little is known about the molecular events specifying this cell lineage. We recently identified two allelic mouse mutants, light coat and circling (Lcc) and yellow submarine (Ysb), that show hearing and balance impairment2. Lcc/Lcc mice are completely deaf, whereas Ysb/Ysb mice are severely hearing impaired2. We report here that inner ears of Lcc/Lcc mice fail to establish a prosensory domain and neither hair cells nor supporting cells differentiate, resulting in a severe inner ear malformation, whereas the sensory epithelium of Ysb/Ysb mice shows abnormal development with disorganized and fewer hair cells. These phenotypes are due to the absence (in Lcc mutants) or reduced expression (in Ysb mutants) of the transcription factor SOX2, specifically within the developing inner ear. SOX2 continues to be expressed in the inner ears of mice lacking Math1 (also known as Atoh1 and HATH1), a gene essential for hair cell differentiation, whereas Math1 expression is absent in Lcc mutants, suggesting that Sox2 acts upstream of Math1.
Persistent Identifierhttp://hdl.handle.net/10722/68180
ISSN
2015 Impact Factor: 38.138
2015 SCImago Journal Rankings: 21.936
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKiernan, AEen_HK
dc.contributor.authorPelling, ALen_HK
dc.contributor.authorLeung, KKHen_HK
dc.contributor.authorTang, ASPen_HK
dc.contributor.authorBell, DMen_HK
dc.contributor.authorTease, Cen_HK
dc.contributor.authorLovellBadge, Ren_HK
dc.contributor.authorSteel, KPen_HK
dc.contributor.authorCheah, KSEen_HK
dc.date.accessioned2010-09-06T06:02:07Z-
dc.date.available2010-09-06T06:02:07Z-
dc.date.issued2005en_HK
dc.identifier.citationNature, 2005, v. 434 n. 7036, p. 1031-1035en_HK
dc.identifier.issn0028-0836en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68180-
dc.description.abstractSensory hair cells and their associated non-sensory supporting cells in the inner ear are fundamental for hearing and balance. They arise from a common progenitor1, but little is known about the molecular events specifying this cell lineage. We recently identified two allelic mouse mutants, light coat and circling (Lcc) and yellow submarine (Ysb), that show hearing and balance impairment2. Lcc/Lcc mice are completely deaf, whereas Ysb/Ysb mice are severely hearing impaired2. We report here that inner ears of Lcc/Lcc mice fail to establish a prosensory domain and neither hair cells nor supporting cells differentiate, resulting in a severe inner ear malformation, whereas the sensory epithelium of Ysb/Ysb mice shows abnormal development with disorganized and fewer hair cells. These phenotypes are due to the absence (in Lcc mutants) or reduced expression (in Ysb mutants) of the transcription factor SOX2, specifically within the developing inner ear. SOX2 continues to be expressed in the inner ears of mice lacking Math1 (also known as Atoh1 and HATH1), a gene essential for hair cell differentiation, whereas Math1 expression is absent in Lcc mutants, suggesting that Sox2 acts upstream of Math1.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_HK
dc.relation.ispartofNatureen_HK
dc.subject.meshAllelesen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBasic Helix-Loop-Helix Transcription Factorsen_HK
dc.subject.meshCell Differentiationen_HK
dc.subject.meshDNA-Binding Proteins - deficiency - genetics - metabolismen_HK
dc.subject.meshEar, Inner - abnormalities - embryology - metabolism - pathologyen_HK
dc.subject.meshHair Cells, Auditory, Inner - abnormalities - metabolism - pathologyen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Mutant Strainsen_HK
dc.subject.meshMutation - geneticsen_HK
dc.subject.meshNerve Tissue Proteins - deficiency - genetics - metabolismen_HK
dc.subject.meshPhenotypeen_HK
dc.subject.meshRNA, Messenger - genetics - metabolismen_HK
dc.subject.meshSOXB1 Transcription Factorsen_HK
dc.subject.meshTrans-Activators - deficiency - genetics - metabolismen_HK
dc.subject.meshTranscription Factors - deficiency - genetics - metabolismen_HK
dc.titleSox2 is required for sensory organ development in the mammalian inner earen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-0836&volume=434&spage=1031&epage=1035. Co&date=2005&atitle=Sox2+is+required+for+sensory+organ+development+in+the+mammalian+inner+earen_HK
dc.identifier.emailLeung, KKH:keithlee@hku.hken_HK
dc.identifier.emailCheah, KSE:hrmbdkc@hku.hken_HK
dc.identifier.authorityLeung, KKH=rp00298en_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nature03487en_HK
dc.identifier.pmid15846349-
dc.identifier.scopuseid_2-s2.0-17844388072en_HK
dc.identifier.hkuros97899en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17844388072&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume434en_HK
dc.identifier.issue7036en_HK
dc.identifier.spage1031en_HK
dc.identifier.epage1035en_HK
dc.identifier.isiWOS:000228524600041-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKiernan, AE=6602878551en_HK
dc.identifier.scopusauthoridPelling, AL=6602962713en_HK
dc.identifier.scopusauthoridLeung, KKH=7401860467en_HK
dc.identifier.scopusauthoridTang, ASP=8384496800en_HK
dc.identifier.scopusauthoridBell, DM=7403648027en_HK
dc.identifier.scopusauthoridTease, C=7004043261en_HK
dc.identifier.scopusauthoridLovellBadge, R=7006432550en_HK
dc.identifier.scopusauthoridSteel, KP=7102712349en_HK
dc.identifier.scopusauthoridCheah, KSE=35387746200en_HK
dc.identifier.citeulike165801-

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