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Article: Signal transduction in the cardiac k-receptor

TitleSignal transduction in the cardiac k-receptor
Authors
Issue Date1995
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
Biological Signals, 1995, v. 4 n. 3, p. 174-178 How to Cite?
AbstractThe presence of k-binding sites in the heart suggests a regulatory role of k-receptor in the cardiac functions. Recent studies have provided evidence that activation of cardiac k-receptor elevates intracellular free calcium ([Ca2+]i) by increasing mobilization of calcium from the intracellular store. The mobilization of intracellular calcium results from an increased production of inositol-1,4,5-trisphosphate (IP3). The increase in [Ca2+]i may manifest in cardiac arrhythmias while the depletion of calcium from the intracellular store may reduce the contractility elicited upon depolarization. The responses of IP3/[Ca2+]i are significantly attenuated after development of tolerance to k-opioids due mainly to the impairment of postreceptor events. The attenuated responses of IP3/[Ca2+]i to k-receptor activation may be responsible for the failure of the k-agonists to induce cardiac arrhythmias and to reduce electrically induced calcium transients in the ventricular myocytes.
Persistent Identifierhttp://hdl.handle.net/10722/68161
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, TMen_HK
dc.contributor.authorSheng, JZen_HK
dc.contributor.authorWong, NSen_HK
dc.contributor.authorTai, KKen_HK
dc.date.accessioned2010-09-06T06:01:56Z-
dc.date.available2010-09-06T06:01:56Z-
dc.date.issued1995en_HK
dc.identifier.citationBiological Signals, 1995, v. 4 n. 3, p. 174-178en_HK
dc.identifier.issn1016-0922en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68161-
dc.description.abstractThe presence of k-binding sites in the heart suggests a regulatory role of k-receptor in the cardiac functions. Recent studies have provided evidence that activation of cardiac k-receptor elevates intracellular free calcium ([Ca2+]i) by increasing mobilization of calcium from the intracellular store. The mobilization of intracellular calcium results from an increased production of inositol-1,4,5-trisphosphate (IP3). The increase in [Ca2+]i may manifest in cardiac arrhythmias while the depletion of calcium from the intracellular store may reduce the contractility elicited upon depolarization. The responses of IP3/[Ca2+]i are significantly attenuated after development of tolerance to k-opioids due mainly to the impairment of postreceptor events. The attenuated responses of IP3/[Ca2+]i to k-receptor activation may be responsible for the failure of the k-agonists to induce cardiac arrhythmias and to reduce electrically induced calcium transients in the ventricular myocytes.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSGen_HK
dc.relation.ispartofBiological Signalsen_HK
dc.rightsBiological Signals. Copyright © S Karger AG.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCalcium - metabolismen_HK
dc.subject.meshHeart - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInositol 1,4,5-Trisphosphate - metabolismen_HK
dc.subject.meshModels, Cardiovascularen_HK
dc.subject.meshMyocardial Contractionen_HK
dc.subject.meshMyocardium - metabolismen_HK
dc.subject.meshReceptors, Opioid, kappa - physiologyen_HK
dc.subject.meshSignal Transductionen_HK
dc.titleSignal transduction in the cardiac k-receptoren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1016-0922&volume=4&spage=174&epage=178&date=1995&atitle=Signal+transduction+in+the+cardiac+k-receptoren_HK
dc.identifier.emailWong, NS:nswong@hkucc.hku.hken_HK
dc.identifier.authorityWong, NS=rp00340en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8750944-
dc.identifier.scopuseid_2-s2.0-0029588521en_HK
dc.identifier.hkuros15467en_HK
dc.identifier.volume4en_HK
dc.identifier.issue3en_HK
dc.identifier.spage174en_HK
dc.identifier.epage178en_HK
dc.identifier.isiWOS:A1995TN13500009-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridWong, TM=7403531434en_HK
dc.identifier.scopusauthoridSheng, JZ=36846286500en_HK
dc.identifier.scopusauthoridWong, NS=7202836641en_HK
dc.identifier.scopusauthoridTai, KK=25935339600en_HK

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