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Article: Apoptosis of human gastric adenocarcinoma cells induced by β-ionone

TitleApoptosis of human gastric adenocarcinoma cells induced by β-ionone
Authors
Issue Date2004
PublisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation
World Journal Of Gastroenterology, 2004, v. 10 n. 3, p. 348-351 How to Cite?
AbstractAim: To investigate the effect of β-ionone on the growth and apoptosis of gastric adenocarcinoma cell line SGC-7901. Methods: Using MTT, fluorescence dye (Hoechst-33258), transmission electron microscopy and the TUNEL assay, we examined growth and apoptosis of SGC-7901 cells treated with β-ionone at various concentrations (i.e. 25, 50, 100 and 200 μmol/L) for 24 h, 48 h. Results: The growth of SGC-7901 cells was inhibited by β-ionone. Seven days after treatment with β-ionone at four concentrations, the inhibition rates were 12.04%, 30.59%, 78.25% and 94.15%, respectively. The IC50 value of β-ionone for SGC-7901 cells was estimated to be 89 μmol/L. The apoptotic morphology was demonstrated in SGC-7901 cells treated with β-ionone by Hoechst-33258 staining and electron microscopy. Apoptosis was also shown in β-ionone-treated SGC-7901 cells by the TUNEL assay. Conclusion: β-ionone can inhibit cell proliferation and induce apoptosis of SGC-7901 cells. However, the mechanism needs to be further investigated.
Persistent Identifierhttp://hdl.handle.net/10722/68154
ISSN
2015 Impact Factor: 2.787
2015 SCImago Journal Rankings: 1.076
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, JRen_HK
dc.contributor.authorChen, BQen_HK
dc.contributor.authorYang, BFen_HK
dc.contributor.authorDong, HWen_HK
dc.contributor.authorSun, CHen_HK
dc.contributor.authorWang, Qen_HK
dc.contributor.authorSong, Gen_HK
dc.contributor.authorSong, YQen_HK
dc.date.accessioned2010-09-06T06:01:52Z-
dc.date.available2010-09-06T06:01:52Z-
dc.date.issued2004en_HK
dc.identifier.citationWorld Journal Of Gastroenterology, 2004, v. 10 n. 3, p. 348-351en_HK
dc.identifier.issn1007-9327en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68154-
dc.description.abstractAim: To investigate the effect of β-ionone on the growth and apoptosis of gastric adenocarcinoma cell line SGC-7901. Methods: Using MTT, fluorescence dye (Hoechst-33258), transmission electron microscopy and the TUNEL assay, we examined growth and apoptosis of SGC-7901 cells treated with β-ionone at various concentrations (i.e. 25, 50, 100 and 200 μmol/L) for 24 h, 48 h. Results: The growth of SGC-7901 cells was inhibited by β-ionone. Seven days after treatment with β-ionone at four concentrations, the inhibition rates were 12.04%, 30.59%, 78.25% and 94.15%, respectively. The IC50 value of β-ionone for SGC-7901 cells was estimated to be 89 μmol/L. The apoptotic morphology was demonstrated in SGC-7901 cells treated with β-ionone by Hoechst-33258 staining and electron microscopy. Apoptosis was also shown in β-ionone-treated SGC-7901 cells by the TUNEL assay. Conclusion: β-ionone can inhibit cell proliferation and induce apoptosis of SGC-7901 cells. However, the mechanism needs to be further investigated.en_HK
dc.languageengen_HK
dc.publisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htmen_HK
dc.relation.ispartofWorld Journal of Gastroenterologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAdenocarcinoma - physiopathologyen_HK
dc.subject.meshApoptosis - drug effectsen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshHumansen_HK
dc.subject.meshNorisoprenoids - pharmacologyen_HK
dc.subject.meshStomach Neoplasms - physiopathologyen_HK
dc.titleApoptosis of human gastric adenocarcinoma cells induced by β-iononeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1007-9327&volume=10&issue=3&spage=348&epage=351&date=2004&atitle=Apoptosis+of+human+gastric+adenocarcinoma+cells+induced+by+β-ionone+en_HK
dc.identifier.emailSong, YQ:songy@hkucc.hku.hken_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3748/wjg.v10.i3.348-
dc.identifier.pmid14760755-
dc.identifier.scopuseid_2-s2.0-1142275461en_HK
dc.identifier.hkuros88153en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1142275461&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue3en_HK
dc.identifier.spage348en_HK
dc.identifier.epage351en_HK
dc.identifier.isiWOS:000208223800008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, JR=26637082300en_HK
dc.identifier.scopusauthoridChen, BQ=25647470000en_HK
dc.identifier.scopusauthoridYang, BF=7404472748en_HK
dc.identifier.scopusauthoridDong, HW=35749869200en_HK
dc.identifier.scopusauthoridSun, CH=7404248892en_HK
dc.identifier.scopusauthoridWang, Q=35306290000en_HK
dc.identifier.scopusauthoridSong, G=7402252898en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK

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