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Article: Over-expression of FoxM1 stimulates cyclin B1 expression

TitleOver-expression of FoxM1 stimulates cyclin B1 expression
Authors
Issue Date2001
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
Citation
Febs Letters, 2001, v. 507 n. 1, p. 59-66 How to Cite?
AbstractFoxM1 (previously named WIN, HFH-11 or Trident) is a Forkhead box (Fox) transcription factor widely expressed in proliferating cells. Various findings, including a recent analysis of FoxM1 knockout mice, suggest that FoxM1 is required for normal S-M coupling during cell cycle progression. To study the regulatory role of FoxM1 and its downstream regulatory targets, three stably transfected HeLa lines that display doxycycline (dox)-inducible FoxM1 expression were established. Over-expression of FoxM1 by dox induction facilitates growth recovery from serum starvation. Quantitation of cyclin B1 and D1 levels using flow cytometric, Western and Northern analyses reveals that elevated FoxM1 levels lead to stimulation of cyclin B1 but not cyclin D1 expression. Transient reporter assays in the dox-inducible lines and upon co-transfection with a constitutive FoxM1 expression plasmid suggest that FoxM1 can activate the cyclin B1 promoter. © 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68153
ISSN
2015 Impact Factor: 3.519
2015 SCImago Journal Rankings: 2.026
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, TWCen_HK
dc.contributor.authorLin, SSWen_HK
dc.contributor.authorTsang, ACCen_HK
dc.contributor.authorTong, CSWen_HK
dc.contributor.authorChing, JCYen_HK
dc.contributor.authorLeung, WYen_HK
dc.contributor.authorGimlich, Ren_HK
dc.contributor.authorWong, GGen_HK
dc.contributor.authorYao, KMen_HK
dc.date.accessioned2010-09-06T06:01:52Z-
dc.date.available2010-09-06T06:01:52Z-
dc.date.issued2001en_HK
dc.identifier.citationFebs Letters, 2001, v. 507 n. 1, p. 59-66en_HK
dc.identifier.issn0014-5793en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68153-
dc.description.abstractFoxM1 (previously named WIN, HFH-11 or Trident) is a Forkhead box (Fox) transcription factor widely expressed in proliferating cells. Various findings, including a recent analysis of FoxM1 knockout mice, suggest that FoxM1 is required for normal S-M coupling during cell cycle progression. To study the regulatory role of FoxM1 and its downstream regulatory targets, three stably transfected HeLa lines that display doxycycline (dox)-inducible FoxM1 expression were established. Over-expression of FoxM1 by dox induction facilitates growth recovery from serum starvation. Quantitation of cyclin B1 and D1 levels using flow cytometric, Western and Northern analyses reveals that elevated FoxM1 levels lead to stimulation of cyclin B1 but not cyclin D1 expression. Transient reporter assays in the dox-inducible lines and upon co-transfection with a constitutive FoxM1 expression plasmid suggest that FoxM1 can activate the cyclin B1 promoter. © 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febsleten_HK
dc.relation.ispartofFEBS Lettersen_HK
dc.rightsF E B S Letters. Copyright © Elsevier BV.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshCell Cycleen_HK
dc.subject.meshCell Divisionen_HK
dc.subject.meshCulture Media, Serum-Freeen_HK
dc.subject.meshCyclin B - genetics - metabolismen_HK
dc.subject.meshCyclin B1en_HK
dc.subject.meshCyclin D1 - genetics - metabolismen_HK
dc.subject.meshDNA - geneticsen_HK
dc.subject.meshDoxycycline - pharmacologyen_HK
dc.subject.meshForkhead Transcription Factorsen_HK
dc.subject.meshGene Expression - drug effectsen_HK
dc.subject.meshGenes, Reporteren_HK
dc.subject.meshHeLa Cellsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLuciferases - geneticsen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshPromoter Regions, Geneticen_HK
dc.subject.meshTranscription Factors - genetics - metabolismen_HK
dc.subject.meshTransfectionen_HK
dc.titleOver-expression of FoxM1 stimulates cyclin B1 expressionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-5793&volume=507&spage=59&epage=66&date=2001&atitle=Over-expression+of+FoxM1+stimulates+cyclin+B1+expressionen_HK
dc.identifier.emailYao, KM:kmyao@hku.hken_HK
dc.identifier.authorityYao, KM=rp00344en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0014-5793(01)02915-5en_HK
dc.identifier.pmid11682060-
dc.identifier.scopuseid_2-s2.0-0035914037en_HK
dc.identifier.hkuros65170en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035914037&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume507en_HK
dc.identifier.issue1en_HK
dc.identifier.spage59en_HK
dc.identifier.epage66en_HK
dc.identifier.isiWOS:000171830200013-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLeung, TWC=36823438900en_HK
dc.identifier.scopusauthoridLin, SSW=15736256500en_HK
dc.identifier.scopusauthoridTsang, ACC=7006979260en_HK
dc.identifier.scopusauthoridTong, CSW=36851991800en_HK
dc.identifier.scopusauthoridChing, JCY=36867072100en_HK
dc.identifier.scopusauthoridLeung, WY=7201504543en_HK
dc.identifier.scopusauthoridGimlich, R=6602847860en_HK
dc.identifier.scopusauthoridWong, GG=7402527602en_HK
dc.identifier.scopusauthoridYao, KM=7403234578en_HK

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