File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Hox homeobox genes and regionalisation of the nervous system

TitleHox homeobox genes and regionalisation of the nervous system
Authors
Issue Date1993
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31737
Citation
Journal Of Neurobiology, 1993, v. 24 n. 10, p. 1328-1340 How to Cite?
AbstractThe Hox family of homeobox-containing genes are intimately associated with the processes of axial patterning in vertebrate embryos. This family of transcription factors is widely conserved in evolution and by analogy with their Drosophila counterparts, the HOM-C homeotic genes, may play a role in establishing regional identity in a number of embryonic systems, including the CNS. The patterns of expression of these genes are linked with the generation of rhombomeres and neural crest in the developing hindbrain, and suggest that they provide a molecular system for generating a combinatorial patterning mechanism. Analysis of mouse Hox mutants generated by homologous recombination have clearly demonstrated that the genes have important roles in normal regionalisation of the hindbrain and branchial arches, and this has lead to interest in how their early patterns are established in the nervous system. The Hox genes and their relation to hindbrain segmentation therefore provide a means of examining the cascade of events which regulates pattern formation in early neural development.
Persistent Identifierhttp://hdl.handle.net/10722/68142
ISSN
2008 Impact Factor: 3.84
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKrumlauf, Ren_HK
dc.contributor.authorMarshall, Hen_HK
dc.contributor.authorStuder, Men_HK
dc.contributor.authorNonchev, Sen_HK
dc.contributor.authorMai Har Shamen_HK
dc.contributor.authorLumsden, Aen_HK
dc.date.accessioned2010-09-06T06:01:46Z-
dc.date.available2010-09-06T06:01:46Z-
dc.date.issued1993en_HK
dc.identifier.citationJournal Of Neurobiology, 1993, v. 24 n. 10, p. 1328-1340en_HK
dc.identifier.issn0022-3034en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68142-
dc.description.abstractThe Hox family of homeobox-containing genes are intimately associated with the processes of axial patterning in vertebrate embryos. This family of transcription factors is widely conserved in evolution and by analogy with their Drosophila counterparts, the HOM-C homeotic genes, may play a role in establishing regional identity in a number of embryonic systems, including the CNS. The patterns of expression of these genes are linked with the generation of rhombomeres and neural crest in the developing hindbrain, and suggest that they provide a molecular system for generating a combinatorial patterning mechanism. Analysis of mouse Hox mutants generated by homologous recombination have clearly demonstrated that the genes have important roles in normal regionalisation of the hindbrain and branchial arches, and this has lead to interest in how their early patterns are established in the nervous system. The Hox genes and their relation to hindbrain segmentation therefore provide a means of examining the cascade of events which regulates pattern formation in early neural development.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31737en_HK
dc.relation.ispartofJournal of Neurobiologyen_HK
dc.rightsJournal of Neurobiology . Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshChromosomesen_HK
dc.subject.meshGene Expressionen_HK
dc.subject.meshGenes, Homeoboxen_HK
dc.subject.meshHead - embryologyen_HK
dc.subject.meshMesoderm - physiologyen_HK
dc.subject.meshNervous System - embryologyen_HK
dc.subject.meshNervous System Physiological Phenomenaen_HK
dc.subject.meshPeriodicityen_HK
dc.subject.meshRhombencephalon - embryologyen_HK
dc.subject.meshSignal Transductionen_HK
dc.subject.meshSpinal Cord - embryologyen_HK
dc.subject.meshVertebrates - embryologyen_HK
dc.titleHox homeobox genes and regionalisation of the nervous systemen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3034&volume=24&spage=1328&epage=1340&date=1993&atitle=Hox+homeobox+genes+and+regionalisation+of+the+nervous+systemen_HK
dc.identifier.emailMai Har Sham:mhsham@hkucc.hku.hken_HK
dc.identifier.authorityMai Har Sham=rp00380en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/neu.480241006en_HK
dc.identifier.pmid7901322-
dc.identifier.scopuseid_2-s2.0-0027493791en_HK
dc.identifier.hkuros8111en_HK
dc.identifier.volume24en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1328en_HK
dc.identifier.epage1340en_HK
dc.identifier.isiWOS:A1993LY32000005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKrumlauf, R=8874137700en_HK
dc.identifier.scopusauthoridMarshall, H=7102515675en_HK
dc.identifier.scopusauthoridStuder, M=7005938648en_HK
dc.identifier.scopusauthoridNonchev, S=6603818489en_HK
dc.identifier.scopusauthoridMai Har Sham=7003729109en_HK
dc.identifier.scopusauthoridLumsden, A=7102213627en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats