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Article: Effect of severity of intervertebral disc injury on mesenchymal stem cell-based regeneration

TitleEffect of severity of intervertebral disc injury on mesenchymal stem cell-based regeneration
Authors
KeywordsAnnulus fibrosus
Intervertebral disc
Mesenchymal stem cells
Nucleus pulposus
Regeneration
Issue Date2008
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03008207.asp
Citation
Connective Tissue Research, 2008, v. 49 n. 1, p. 15-21 How to Cite?
AbstractMesenchymal stem cell (MSC) implantation has been shown previously to arrest disc degeneration. This study aims to assess the effect of severity of disc degeneration on the ability of MSCs to arrest the degeneration. Disc degeneration was induced in New Zealand white rabbits at lumbar levels by annular puncture. The degeneration was allowed to progress for 1 month (early group) or 7 months (late group), followed by intradiscal injection of autologous MSCs. For disc levels that received MSCs treatment, 1 × 10 5 BrdU-labeled MSCs were injected per disc level. For the early group, MSC-injection had no significant effects on disc height or the progression of disc degeneration. For the late group, although the MSC-injected discs displayed lower disc heights than the control discs, they were significantly less degenerated together with near normal level of proteoglycan in localized areas. This is the first pilot study to demonstrate that severity of degeneration can influence the therapeutic effect of MSCs. Future studies of cell-based intervertebral disc regeneration should be carefully controlled in the context of stage of disc degeneration.
Persistent Identifierhttp://hdl.handle.net/10722/68117
ISSN
2015 Impact Factor: 1.411
2015 SCImago Journal Rankings: 0.622
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, Gen_HK
dc.contributor.authorLeung, VYLen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorChan, Den_HK
dc.date.accessioned2010-09-06T06:01:30Z-
dc.date.available2010-09-06T06:01:30Z-
dc.date.issued2008en_HK
dc.identifier.citationConnective Tissue Research, 2008, v. 49 n. 1, p. 15-21en_HK
dc.identifier.issn0300-8207en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68117-
dc.description.abstractMesenchymal stem cell (MSC) implantation has been shown previously to arrest disc degeneration. This study aims to assess the effect of severity of disc degeneration on the ability of MSCs to arrest the degeneration. Disc degeneration was induced in New Zealand white rabbits at lumbar levels by annular puncture. The degeneration was allowed to progress for 1 month (early group) or 7 months (late group), followed by intradiscal injection of autologous MSCs. For disc levels that received MSCs treatment, 1 × 10 5 BrdU-labeled MSCs were injected per disc level. For the early group, MSC-injection had no significant effects on disc height or the progression of disc degeneration. For the late group, although the MSC-injected discs displayed lower disc heights than the control discs, they were significantly less degenerated together with near normal level of proteoglycan in localized areas. This is the first pilot study to demonstrate that severity of degeneration can influence the therapeutic effect of MSCs. Future studies of cell-based intervertebral disc regeneration should be carefully controlled in the context of stage of disc degeneration.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03008207.aspen_HK
dc.relation.ispartofConnective Tissue Researchen_HK
dc.rightsConnective Tissue Research. Copyright © Informa Healthcare.en_HK
dc.subjectAnnulus fibrosusen_HK
dc.subjectIntervertebral discen_HK
dc.subjectMesenchymal stem cellsen_HK
dc.subjectNucleus pulposusen_HK
dc.subjectRegenerationen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBromodeoxyuridineen_HK
dc.subject.meshIntervertebral Disc - injuries - physiology - radiographyen_HK
dc.subject.meshMesenchymal Stem Cell Transplantationen_HK
dc.subject.meshModels, Biologicalen_HK
dc.subject.meshPilot Projectsen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshRegeneration - physiologyen_HK
dc.subject.meshTime Factorsen_HK
dc.titleEffect of severity of intervertebral disc injury on mesenchymal stem cell-based regenerationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-8207&volume=49&spage=15&epage=21&date=2008&atitle=Effect+of+severity+of+intervertebral+disc+injury+on+mesenchymal+stem+cell-based+regenerationen_HK
dc.identifier.emailLeung, VYL: vicleung@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailChan, D: chand@hkucc.hku.hken_HK
dc.identifier.authorityLeung, VYL=rp01764en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/03008200701818595en_HK
dc.identifier.pmid18293174-
dc.identifier.scopuseid_2-s2.0-39749134693en_HK
dc.identifier.hkuros140333en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-39749134693&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue1en_HK
dc.identifier.spage15en_HK
dc.identifier.epage21en_HK
dc.identifier.isiWOS:000253508900003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHo, G=23667209200en_HK
dc.identifier.scopusauthoridLeung, VYL=35337438900en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.citeulike7592189-

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