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Article: An effective dose of valdecoxib in experimental mouse models of pain

TitleAn effective dose of valdecoxib in experimental mouse models of pain
Authors
KeywordsAnalgesic efficacy
Experimental mouse model
Valdecoxib
Issue Date2007
PublisherProus Science. The Journal's web site is located at http://www.prous.com/journals/mf/20042606/index.cfm
Citation
Methods And Findings In Experimental And Clinical Pharmacology, 2007, v. 29 n. 6, p. 383-388 How to Cite?
AbstractThe effects of selective cyclooxygenase-2 (COX-2) inhibitors in biological functions are frequently investigated in animal models. However, there is little data on their analgesic efficacy in experimental animals. This study aimed to determine whether oral gavage of 5 mg/kg valdecoxib in mice is active as an analgesic at this dose and whether it is associated with therapeutic blood levels. A nonselective COX inhibitor, ketorolac, was also investigated for comparison. A total of 106 C57 BL/6N mice were administered a single oral dose of 5 mg/kg of valdecoxib, ketorolac or placebo. The antinociceptive effects of both drugs were tested using hot-plate and formalin tests. For the hot-plate test, reaction time (latency) of the mouse before jumping was recorded. The total time that the mouse spent on licking/biting the injected paw (with dilute formalin) was recorded in the formalin test. Apart from the behavioral tests, plasma concentrations of the drugs at this dose were also determined. Mice were fed with 5 mg/kg of either valdecoxib or ketorolac. Blood samples were collected between 1 and 9 h postingestion. Valdecoxib and ketorolac concentration in the plasma was determined by high performance liquid chromatography with ultraviolet detection (HPLC-UV). Effective antinociception was observed for both drugs in the hot-plate test from 75 min to 2 h after oral dosing. Also, both drug treatments showed a significantly reduced nociceptive response in the second phase in the formalin test (20-30 min after injection). Both valdecoxib and ketorolac showed plasma concentrations comparable to the therapeutic concentrations in humans. A single oral dose of valdecoxib or ketorolac (5 mg/kg) is able to produce a therapeutic analgesic effect in mice. © 2007 Prous Science. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68106
ISSN
2012 Impact Factor: 0.774
2013 SCImago Journal Rankings: 0.220
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuo, CXXen_HK
dc.contributor.authorIrwin, MGen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorChan, Den_HK
dc.date.accessioned2010-09-06T06:01:24Z-
dc.date.available2010-09-06T06:01:24Z-
dc.date.issued2007en_HK
dc.identifier.citationMethods And Findings In Experimental And Clinical Pharmacology, 2007, v. 29 n. 6, p. 383-388en_HK
dc.identifier.issn0379-0355en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68106-
dc.description.abstractThe effects of selective cyclooxygenase-2 (COX-2) inhibitors in biological functions are frequently investigated in animal models. However, there is little data on their analgesic efficacy in experimental animals. This study aimed to determine whether oral gavage of 5 mg/kg valdecoxib in mice is active as an analgesic at this dose and whether it is associated with therapeutic blood levels. A nonselective COX inhibitor, ketorolac, was also investigated for comparison. A total of 106 C57 BL/6N mice were administered a single oral dose of 5 mg/kg of valdecoxib, ketorolac or placebo. The antinociceptive effects of both drugs were tested using hot-plate and formalin tests. For the hot-plate test, reaction time (latency) of the mouse before jumping was recorded. The total time that the mouse spent on licking/biting the injected paw (with dilute formalin) was recorded in the formalin test. Apart from the behavioral tests, plasma concentrations of the drugs at this dose were also determined. Mice were fed with 5 mg/kg of either valdecoxib or ketorolac. Blood samples were collected between 1 and 9 h postingestion. Valdecoxib and ketorolac concentration in the plasma was determined by high performance liquid chromatography with ultraviolet detection (HPLC-UV). Effective antinociception was observed for both drugs in the hot-plate test from 75 min to 2 h after oral dosing. Also, both drug treatments showed a significantly reduced nociceptive response in the second phase in the formalin test (20-30 min after injection). Both valdecoxib and ketorolac showed plasma concentrations comparable to the therapeutic concentrations in humans. A single oral dose of valdecoxib or ketorolac (5 mg/kg) is able to produce a therapeutic analgesic effect in mice. © 2007 Prous Science. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherProus Science. The Journal's web site is located at http://www.prous.com/journals/mf/20042606/index.cfmen_HK
dc.relation.ispartofMethods and Findings in Experimental and Clinical Pharmacologyen_HK
dc.subjectAnalgesic efficacyen_HK
dc.subjectExperimental mouse modelen_HK
dc.subjectValdecoxiben_HK
dc.subject.meshAdministration, Oralen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshChromatography, High Pressure Liquiden_HK
dc.subject.meshCyclooxygenase Inhibitors - administration & dosage - blood - therapeutic useen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFormaldehydeen_HK
dc.subject.meshHot Temperatureen_HK
dc.subject.meshIsoxazoles - administration & dosage - blood - therapeutic useen_HK
dc.subject.meshKetorolac - administration & dosage - blood - therapeutic useen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred C57BLen_HK
dc.subject.meshNociceptors - drug effectsen_HK
dc.subject.meshPain - drug therapyen_HK
dc.subject.meshPain Measurementen_HK
dc.subject.meshReaction Time - drug effectsen_HK
dc.subject.meshSulfonamides - administration & dosage - blood - therapeutic useen_HK
dc.titleAn effective dose of valdecoxib in experimental mouse models of painen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0379-0355&volume=29&issue=6&spage=383&epage=388&date=2007&atitle=An+effective+dose+of+Valdecoxib+in+experimental+mouse+models+of+painen_HK
dc.identifier.emailIrwin, MG:mgirwin@hku.hken_HK
dc.identifier.emailCheung, KMC:cheungmc@hku.hken_HK
dc.identifier.emailChan, D:chand@hkucc.hku.hken_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1358/mf.2007.29.6.1119170en_HK
dc.identifier.pmid17922065en_HK
dc.identifier.scopuseid_2-s2.0-35348986578en_HK
dc.identifier.hkuros145978en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35348986578&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue6en_HK
dc.identifier.spage383en_HK
dc.identifier.epage388en_HK
dc.identifier.isiWOS:000250070800002-
dc.publisher.placeSpainen_HK
dc.identifier.scopusauthoridGuo, CXX=22934384300en_HK
dc.identifier.scopusauthoridIrwin, MG=7202411076en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK

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