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Article: Prediction of quaternary assembly of SARS coronavirus peplomer

TitlePrediction of quaternary assembly of SARS coronavirus peplomer
Authors
Bernini, ASpiga, OCiutti, AChiellini, SBracci, LYan, XZheng, BHuang, JHe, MLSong, HDHao, PZhao, GNiccolai, N
KeywordsQuaternary structure prediction
SARS coronavirus
Spike glycoprotein
Issue Date2004
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2004, v. 325 n. 4, p. 1210-1214 How to Cite?
DOI: http://dx.doi.org/10.1016/j.bbrc.2004.10.156
AbstractThe tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is suggested. The interaction between S1 and S2 appears to be stabilised by a large hydrophobic network of aromatic side chains present in both domains. This feature results to be common to all coronaviruses, suggesting potential targeting for drugs preventing coronavirus-related infections. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68105
ISSN
0006-291X
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.770
ISI Accession Number ID
WOS:000225557500013
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorBernini, Aen_HK
dc.contributor.authorSpiga, Oen_HK
dc.contributor.authorCiutti, Aen_HK
dc.contributor.authorChiellini, Sen_HK
dc.contributor.authorBracci, Len_HK
dc.contributor.authorYan, Xen_HK
dc.contributor.authorZheng, Ben_HK
dc.contributor.authorHuang, Jen_HK
dc.contributor.authorHe, MLen_HK
dc.contributor.authorSong, HDen_HK
dc.contributor.authorHao, Pen_HK
dc.contributor.authorZhao, Gen_HK
dc.contributor.authorNiccolai, Nen_HK
dc.date.accessioned2010-09-06T06:01:23Z-
dc.date.available2010-09-06T06:01:23Z-
dc.date.issued2004en_HK
dc.identifier.citationBiochemical And Biophysical Research Communications, 2004, v. 325 n. 4, p. 1210-1214en_HK
dc.identifier.issn0006-291Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/68105-
dc.description.abstractThe tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is suggested. The interaction between S1 and S2 appears to be stabilised by a large hydrophobic network of aromatic side chains present in both domains. This feature results to be common to all coronaviruses, suggesting potential targeting for drugs preventing coronavirus-related infections. © 2004 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_HK
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_HK
dc.subjectQuaternary structure predictionen_HK
dc.subjectSARS coronavirusen_HK
dc.subjectSpike glycoproteinen_HK
dc.subject.meshAmino Acid Substitutionen_HK
dc.subject.meshBinding Sitesen_HK
dc.subject.meshComputer Simulationen_HK
dc.subject.meshMembrane Glycoproteins - analysis - chemistryen_HK
dc.subject.meshModels, Chemicalen_HK
dc.subject.meshModels, Molecularen_HK
dc.subject.meshProtein Bindingen_HK
dc.subject.meshProtein Conformationen_HK
dc.subject.meshProtein Structure, Quaternaryen_HK
dc.subject.meshProtein Structure, Tertiaryen_HK
dc.subject.meshSequence Analysis, Protein - methodsen_HK
dc.subject.meshStructure-Activity Relationshipen_HK
dc.subject.meshViral Envelope Proteins - analysis - chemistryen_HK
dc.titlePrediction of quaternary assembly of SARS coronavirus peplomeren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-291X&volume=325&spage=1210&epage=1214&date=2004&atitle=Prediction+of+quaternary+assembly+of+SARS+coronavirus+peplomeren_HK
dc.identifier.emailZheng, B:bzheng@hkucc.hku.hken_HK
dc.identifier.emailHuang, J:jdhuang@hkucc.hku.hken_HK
dc.identifier.authorityZheng, B=rp00353en_HK
dc.identifier.authorityHuang, J=rp00451en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbrc.2004.10.156en_HK
dc.identifier.pmid15555555-
dc.identifier.scopuseid_2-s2.0-8844256739en_HK
dc.identifier.hkuros102965en_HK
dc.identifier.hkuros97131-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-8844256739&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume325en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1210en_HK
dc.identifier.epage1214en_HK
dc.identifier.isiWOS:000225557500013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBernini, A=7004103621en_HK
dc.identifier.scopusauthoridSpiga, O=6603012863en_HK
dc.identifier.scopusauthoridCiutti, A=6602262010en_HK
dc.identifier.scopusauthoridChiellini, S=6602341238en_HK
dc.identifier.scopusauthoridBracci, L=7006252899en_HK
dc.identifier.scopusauthoridYan, X=7403596132en_HK
dc.identifier.scopusauthoridZheng, B=7201780588en_HK
dc.identifier.scopusauthoridHuang, J=8108660600en_HK
dc.identifier.scopusauthoridHe, ML=35080389700en_HK
dc.identifier.scopusauthoridSong, HD=9745126600en_HK
dc.identifier.scopusauthoridHao, P=7005522275en_HK
dc.identifier.scopusauthoridZhao, G=7403296532en_HK
dc.identifier.scopusauthoridNiccolai, N=7003440494en_HK
dc.identifier.issnl0006-291X-

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