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Article: Tertiary structure prediction of SARS coronavirus helicase

TitleTertiary structure prediction of SARS coronavirus helicase
Authors
Issue Date2006
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2006, v. 343 n. 4, p. 1101-1104 How to Cite?
AbstractSARS coronavirus, SCV, has been recently responsible of a sudden and widespread infection which caused almost 800 victims. The limited amount of SCV protein structural information is partially responsible of the lack of specific drugs against the virus. Coronavirus helicases are very conserved and peculiar proteins which have been proposed as suitable targets for antiviral drugs, such as bananins, which have been recently shown to inhibit the SCV helicase in vitro. Here, the quaternary structure of SCV helicase has been predicted, which will provide a solid foundation for the rational design of other antiviral helicase inhibitors. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68094
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBernini, Aen_HK
dc.contributor.authorSpiga, Oen_HK
dc.contributor.authorVenditti, Ven_HK
dc.contributor.authorPrischi, Fen_HK
dc.contributor.authorBracci, Len_HK
dc.contributor.authorHuang, Jen_HK
dc.contributor.authorTanner, JAen_HK
dc.contributor.authorNiccolai, Nen_HK
dc.date.accessioned2010-09-06T06:01:17Z-
dc.date.available2010-09-06T06:01:17Z-
dc.date.issued2006en_HK
dc.identifier.citationBiochemical And Biophysical Research Communications, 2006, v. 343 n. 4, p. 1101-1104en_HK
dc.identifier.issn0006-291Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/68094-
dc.description.abstractSARS coronavirus, SCV, has been recently responsible of a sudden and widespread infection which caused almost 800 victims. The limited amount of SCV protein structural information is partially responsible of the lack of specific drugs against the virus. Coronavirus helicases are very conserved and peculiar proteins which have been proposed as suitable targets for antiviral drugs, such as bananins, which have been recently shown to inhibit the SCV helicase in vitro. Here, the quaternary structure of SCV helicase has been predicted, which will provide a solid foundation for the rational design of other antiviral helicase inhibitors. © 2006 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_HK
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_HK
dc.subject.meshBinding Sitesen_HK
dc.subject.meshComputer Simulationen_HK
dc.subject.meshDNA Helicases - chemistryen_HK
dc.subject.meshModels, Molecularen_HK
dc.subject.meshProtein Structure, Tertiaryen_HK
dc.subject.meshSARS Virus - enzymologyen_HK
dc.subject.meshSequence Analysis, Proteinen_HK
dc.subject.meshViral Proteins - chemistryen_HK
dc.titleTertiary structure prediction of SARS coronavirus helicaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-291X&volume=343&spage=1101&epage=1104&date=2006&atitle=Tertiary+structure+prediction+of+SARS+coronavirus+helicaseen_HK
dc.identifier.emailHuang, J:jdhuang@hkucc.hku.hken_HK
dc.identifier.emailTanner, JA:jatanner@hku.hken_HK
dc.identifier.authorityHuang, J=rp00451en_HK
dc.identifier.authorityTanner, JA=rp00495en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbrc.2006.03.069en_HK
dc.identifier.pmid16579970-
dc.identifier.scopuseid_2-s2.0-33646049051en_HK
dc.identifier.hkuros115496en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646049051&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume343en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1101en_HK
dc.identifier.epage1104en_HK
dc.identifier.isiWOS:000237269000016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBernini, A=7004103621en_HK
dc.identifier.scopusauthoridSpiga, O=6603012863en_HK
dc.identifier.scopusauthoridVenditti, V=8560856700en_HK
dc.identifier.scopusauthoridPrischi, F=6505683929en_HK
dc.identifier.scopusauthoridBracci, L=7006252899en_HK
dc.identifier.scopusauthoridHuang, J=8108660600en_HK
dc.identifier.scopusauthoridTanner, JA=35513993000en_HK
dc.identifier.scopusauthoridNiccolai, N=7003440494en_HK

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